1. Articles from Davide Iannuzzi

    1-6 of 6
    1. Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography

      Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography

      ABSTRACT The mechanical behavior of dermal tissues is unarguably recognized for its diagnostic ability and in the last decades received a steadily increasing interest in dermatology practices. Among the various methods to investigate the mechanics of skin in clinical environments, suction-based ones are especially noteworthy, thanks to their qualities of minimal invasiveness and relative simplicity of setups and data analysis. In such experiments, structural visualization of the sample is highly desirable, both in its own right and because it enables elastography. The latter is a technique that combines the knowledge of an applied mechanical stimulus and the visualization of the ...

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    2. In vivo characterization of chick embryo mesoderm by optical coherence tomography assisted microindentation

      In vivo characterization of chick embryo mesoderm by optical coherence tomography assisted microindentation

      Embryos are growing organisms with highly heterogeneous properties in space and time. Understanding the mechanical properties is a crucial prerequisite for the investigation of morphogenesis. During the last ten years, new techniques have been developed to evaluate the mechanical properties of biological tissues in vivo . To address this need, we employed a new instrument that, via the combination of micro-indentation with Optical Coherence Tomography (OCT), allows us to determine both, the spatial distribution of mechanical properties of chick embryos and the structural changes in real-time provided by OCT. We report here the stiffness measurements on live chicken mesoderm during somite ...

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    3. Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: Experimental setup and measurements on fixed chicken embryos.

      Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: Experimental setup and measurements on fixed chicken embryos.

      The investigation of the mechanical properties of embryos is expected to provide valuable information on the phenomenology of morphogenesis. It is thus believed that, by mapping the viscoelastic features of an embryo at different stages of growth, it may be possible to shed light on the role of mechanics in embryonic development. To contribute to this field, we present a new instrument that can determine spatiotemporal distributions of mechanical properties of embryos over a wide area and with unprecedented accuracy. The method relies on combining ferrule-top micro-indentation, which provides local measurements of viscoelasticity, with Optical Coherence Tomography, which can reveal ...

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    4. Micro-indentation and optical coherence tomography for the mechanical characterization of embryos

      Micro-indentation and optical coherence tomography for the mechanical characterization of embryos

      The investigation of the mechanical properties of embryos is expected to provide valuable information on the phenomenology of morphogenesis. It is thus believed that, by mapping the viscoelastic features of an embryo at different stages of growth, it may be possible to shed light on the role of mechanics in embryonic development. To contribute to this field, we present a new instrument that can determine spatiotemporal distributions of mechanical properties of embryos over a wide area and with unprecedented accuracy. The method relies on combining ferrule-top micro-indentation, which provides local measurements of viscoelasticity, with Optical Coherence Tomography, which can reveal ...

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    5. 70  μm diameter optical probe for common-path optical coherence tomography in air and liquids

      70  μm diameter optical probe for common-path optical coherence tomography in air and liquids

      We investigate and validate a novel method to fabricate ultrathin optical probes for common-path optical coherence tomography (CP-OCT). The probes are obtained using a 65 μm barium titanate microsphere inserted into an inward concave cone chemically etched at the end of a single-mode fiber. We demonstrate that the high refractive index (

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    6. Collecting optical coherence elastography depth profiles with a micromachined cantilever probe

      Collecting optical coherence elastography depth profiles with a micromachined cantilever probe

      We present an experimental setup that combines optical coherence elastography depth sensing with atomic force microscope indentation. The instrument relies on a miniaturized cantilever probe that compresses a sample with a small footprint force and simultaneously collects an optical coherence tomography (OCT) depth profile underneath the indenting point. The deflection of the cantilever can be monitored via optical fiber interferometry with a resolution of 2 nm. The OCT readout then provides depth profiles of the subsurface layer deformation with 15 nm resolution and depth range of a few millimeters.

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    1-6 of 6
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  2. Topics in the News

    1. (5 articles) VU University Amsterdam
    2. (2 articles) Academic Medical Center at the University of Amsterdam
    3. (2 articles) University Medical Center Utrecht
    4. (2 articles) Johannes F. de Boer
    5. (1 articles) Medical University of Vienna
    6. (1 articles) Jianhua Mo
    7. (1 articles) Mattijs de Groot
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    Collecting optical coherence elastography depth profiles with a micromachined cantilever probe 70  μm diameter optical probe for common-path optical coherence tomography in air and liquids Micro-indentation and optical coherence tomography for the mechanical characterization of embryos Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: Experimental setup and measurements on fixed chicken embryos. In vivo characterization of chick embryo mesoderm by optical coherence tomography assisted microindentation Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography Fantom Encore Sirolimus-eluting Bioresorbable Scaffold for Treatment of De-novo CAD: the ENCORE-I Study Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA OCT system used at home demonstrates potential for daily monitoring of AMD Optical Coherence Tomography Biomarkers of the Outer Blood—Retina Barrier in Patients with Diabetic Macular Oedema Retinal Boundary Segmentation in Stargardt Disease Optical Coherence Tomography Images Using Automated Multi-channel swept source optical coherence tomography concept based on photonic integrated circuits