1. Articles from N. M. Fried

    1-2 of 2
    1. Optical Coherence Tomography of Cavernous Nerves: A Step Toward Real-Time Intraoperative Imaging During Nerve-Sparing Radical Prostatectomy.

      OBJECTIVES: To demonstrate the use of optical coherence tomography (OCT) for imaging of the cavernous nerve (CN) and periprostatic tissues. The rates of nerve preservation and postoperative potency after radical prostatectomy might improve with better identification of the CN using emerging intraoperative imaging modalities. OCT is an imaging modality that allows for real-time, high-resolution, cross-sectional imaging of tissues. METHODS: Seven male Sprague-Dawley rats underwent surgery using a midline celiotomy to expose the bladder, prostate, and seminal vesicles. The CNs and major pelvic ganglion were identified. Visual identification of the CN was further confirmed by electrical stimulation with simultaneous intracorporeal pressure ...
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    2. Identification and Imaging of the Nerves Responsible for Erectile Function in Rat Prostate, In Vivo, Using Optical Nerve Stimulation and Optical Coherence Tomography

      The cavernous nerves on the prostate surface are responsible for erectile function. Optical diagnostic tools such as optical coherence tomography and laser nerve stimulation may assist in the identification, imaging, and preservation of these microscopic nerves during prostate cancer surgery, and thus, help preserve sexual function after surgery. The feasibility of noncontact laser stimulation of the cavernous nerves is demonstrated in an in vivo rat prostate model with comparison to conventional electrical nerve stimulation. High-resolution optical coherence tomographic images of the nerves are also obtained and compared with histology. These optical technologies may be suitable as surgical guidance tools during ...
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    1-2 of 2
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