1. Articles from Chang-Hao Yang

    1-11 of 11
    1. Quantitative analysis of branching neovascular networks in polypoidal choroidal vasculopathy by optical coherence tomography angiography after photodynamic therapy and anti-vascular endothelial growth factor combination therapy

      Quantitative analysis of branching neovascular networks in polypoidal choroidal vasculopathy by optical coherence tomography angiography after photodynamic therapy and anti-vascular endothelial growth factor combination therapy

      Purpose: To study serial changes in branching neovascular networks (BNN) by using optical coherence tomography angiography (OCTA) in patients with polypoidal choroidal vasculopathy (PCV) who underwent combined photodynamic therapy (PDT) and anti-vascular endothelial growth factor (anti-VEGF) therapy. Methods: In this retrospective study of 30 PCV patients who underwent combined therapy, OCTA images obtained at baseline and 1, 3, and 6 months after treatment were collected. The vessel area, vessel percentage area, average vessel length, and presence of polypoidal lesions on OCTA images as well as best-corrected visual acuity (BCVA), central retinal thickness (CRT), and central choroidal thickness (CCT) were recorded ...

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    2. Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography

      Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography

      This study highlights the clinical features and treatment response of polypoidal choroidal vasculopathy (PCV) among three different branching vascular network (BVN) morphologies in optical coherence tomography angiography (OCTA), and further correlates the BVN features with those under fluorescent angiography (FA) and indocyanine green angiography (ICGA). In total, we reviewed 70 eyes with PCV followed up for > 12 months. OCTA, ICGA and FA images were obtained at baseline and post-treatments. BVN was assessed using OCTA and divided into three types by a previously described BVN classification: type 1 (trunk), type 2 (glomeruli), and type 3 (stick). At baseline, type 1 BVN ...

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    3. The structure-function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa

      The structure-function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa

      To investigate the structure-function correlation analysed by full-field electroretinography (ffERG) and optical coherence tomography (OCT) in typical and pericentral subtypes of retinitis pigmentosa (RP). A retrospective, cross-sectional, observational study of right eyes was conducted. The primary analysis used ffERG data to compare the RP subtypes. The subgroup analysis was used to correlate the structure, analysed by OCT, and function, determined by ffERG. Linear regressions explored the relationship between best-corrected visual acuity (BCVA) and multiple parameters. A total of 188 eyes were included. Amplitudes of responses of rod, rod-cone, cone, and 30 Hz flicker of typical type were lower than those ...

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    4. Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration

      Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration

      Purpose: To investigate choroidal neovascularization (CNV) activity after anti-vascular endothelial growth factor (anti-VEGF) therapy in patients with neovascular age-related macular degeneration (nAMD) by optical coherence tomography angiography (OCTA) and to determine whether combined qualitative and quantitative biomarkers can achieve high predictive accuracy to guide treatment decisions. Methods: Patients diagnosed with type 1 or type 2 CNV via multimodal imaging who had received anti-VEGF treatmentwere retrospectively reviewed. Qualitative and quantitative CNV responses on OCTA after serial injections were analyzed, and the assessment was correlated with their structural OCT scans. The enrolled eyes were divided into two groups: eyes with exudative signs ...

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    5. Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema

      Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema

      Purpose To explore the impact of macular ischaemia on vision in diabetic macular oedema (DMO) by analysing the correlations between visual acuity and macular microvascular parameters using optical coherence tomography angiography (OCTA). Methods OCTA was performed in 81 eyes of 48 patients with DMO, and 3 × 3-mm 2 en face OCTA images of the superficial capillary plexus and deep capillary plexus in the central macula were retrospectively collected. Microvascular parameters including the number of microaneurysms, area of foveal avascular zone (FAZ), acircularity index of FAZ, vessel density, skeleton density, vessel density index and fractal dimension were measured. Central retinal thickness ...

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    6. Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study

      Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study

      This study evaluated the characteristic changes in optical coherence tomography (OCT) biomarkers in neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor drugs and their relationship with visual outcomes at 1-year follow-up in a real-world setting. We retrospectively reviewed the medical records of 126 eyes with nAMD treated with either intravitreal ranibizumab or aflibercept, including ophthalmologic examinations and spectral-domain OCT at baseline and months 3, 6, and 12 after first injection. Treatment response of intraretinal cysts (IRCs), subretinal fluid (SRF), and pigment epithelial detachment (PED), and the correlation between best-corrected visual acuity (BCVA) changes and these OCT biomarkers ...

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    7. Characterizing Branching Vascular Network Morphology in Polypoidal Choroidal Vasculopathy by Optical Coherence Tomography Angiography

      Characterizing Branching Vascular Network Morphology in Polypoidal Choroidal Vasculopathy by Optical Coherence Tomography Angiography

      This study analyze the morphological characteristics of branching vascular networks (BVN) in polypoidal choroidal vasculopathy (PCV) using optical coherence tomography angiography (OCTA), and correlate imaging characteristics with clinical presentations. We presented a retrospective observational case series for fifty cases of PCV confirmed by indocyanine green angiography. Macular OCTA were done by the AngioVue. The PCV cases were classified by distinct morphologic patterns of BVN by two retina specialists and clinical features were analyzed. The sensitivity of polyp detection by OCTA was 86% after manual segmentation and that of BVN was 90%. Three distinct morphologic patterns of BVN were identified. (1 ...

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    8. Optical Coherence Tomography Angiography for Assessment of the 3-Dimensional Structures of Polypoidal Choroidal Vasculopathy

      Optical Coherence Tomography Angiography for Assessment of the 3-Dimensional Structures of Polypoidal Choroidal Vasculopathy

      Importance Investigating the quantitative 3-dimensional (3-D) anatomy of polypoidal complex is important for a better understanding of the pathogenesis of polypoidal choroidal vasculopathy (PCV). Objective To quantitatively evaluate the 3-D characteristics of polypoidal structures, branching vascular networks (BVNs), and origin of PCV using optical coherence tomography angiography (OCTA) and multiple image systems. Design, Setting, and Participants A prospective, observational study was conducted in 47 consecutive Taiwanese patients (47 eyes) from May 21, 2015, to April 30, 2017. All participants were scanned with the Optovue-RTVue-XR-Avanti OCTA system. Patients in whom PCV was identified on OCTA were examined to define characteristics and ...

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    9. The Value of Combining Autofluorescence and Optical Coherence Tomography in Predicting the Visual Prognosis of Sealed Macular Holes

      The Value of Combining Autofluorescence and Optical Coherence Tomography in Predicting the Visual Prognosis of Sealed Macular Holes

      Purpose To investigate the autofluorescence patterns of sealed macular holes and determine the correlations of the postoperative changes in spectral-domain optical coherence tomography and fundus autofluorescence (FAF) with the best-corrected visual acuity (BCVA) of patients with sealed idiopathic macular holes. Design Retrospective consecutive observational case series. Methods Seventy-seven eyes from 75 consecutive patients who had undergone successful vitrectomies for idiopathic macular holes by a single surgeon with postoperative follow-ups for over 1 year were included. FAF imaging studies were performed 1 month and 6 months post surgery, and optical coherence tomography (OCT) was performed at regular intervals after surgery. The ...

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    10. Long-term study of vitreomacular traction syndrome: Optical coherence tomographic patterns and surgical results

      Long-term study of vitreomacular traction syndrome: Optical coherence tomographic patterns and surgical results

      Purpose To investigate the optical coherence tomographic (OCT) patterns and long-term surgical outcomes of patients with vitreomacular traction syndrome (VMT). Methods From May 2002 to April 2008, patients with OCT-confirmed VMT who underwent vitrectomy were retrospectively reviewed. Complete pre- and postoperative ophthalmic and OCT examinations were recorded. All cases were followed for at least 2 years. The OCT patterns of VMT were classified into two groups: Group 1, V-shaped macular traction (1A: without macular detachment, 1B: with macular detachment); Group 2, U-shaped macular traction (2A: without macular detachment, 2B: with macular detachment). Multiple linear regression analysis of selective factors was ...

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    11. Macular appearance after diabetic vitrectomy for fibrovascular proliferation: an optical coherence tomography study.

      ABSTRACT Purpose: To investigate morphological variations in the macular area with optical coherence tomography (OCT) after vitrectomy for diabetic fibrovascular proliferation. Methods: We reviewed 108 cases using OCT 7–15 months after vitrectomy. Of these, 32 received OCT within 3 months postoperatively. Morphological variations were catego...
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    1-11 of 11
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    Long-term study of vitreomacular traction syndrome: Optical coherence tomographic patterns and surgical results The Value of Combining Autofluorescence and Optical Coherence Tomography in Predicting the Visual Prognosis of Sealed Macular Holes Optical Coherence Tomography Angiography for Assessment of the 3-Dimensional Structures of Polypoidal Choroidal Vasculopathy Characterizing Branching Vascular Network Morphology in Polypoidal Choroidal Vasculopathy by Optical Coherence Tomography Angiography Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration The structure-function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study Automatic Segmentation and Measurement of Choroid Layer in High Myopia for OCT Imaging Using Deep Learning In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography