1. Articles from F. Paul

    1-4 of 4
    1. Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

      Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

      Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber ...

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    2. Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

      Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

      Background and purpose Some 3%−10% of patients with multiple sclerosis (MS) experience disease onset before the age of 18 years (‘early’ onset MS, EOMS). Optical coherence tomography is a non-invasive method to measure retinal nerve fibre layer thickness (RNFLT) and total macular volume (TMV) and may be useful to differentiate axonal and neuronal damage in the retina of patients with a history of EOMS. Here RNFLT and TMV in EOMS patients after a mean disease duration of 11.6 years were compared with patients with age- or disease-duration-matched later onset MS (LOMS) and healthy controls (HCs). Methods In this ...

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    3. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. Objective: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. Methods: A prospective multi-centre ( n = 13) study. Peripapillary ring scan QC rating of an OCT training set ( n = 50) was followed by a test set ( n = 50). Inter-rater agreement was calculated using kappa statistics. Results were ...

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    4. Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis

      Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis

      Background and purpose In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) – with its potential to reveal neuroaxonal retinal damage – may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity. Methods Seventy-six ALS patients (144 eyes) and 54 ...

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    1-4 of 4
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  2. Topics in the News

    1. (3 articles) Johns Hopkins University
    2. (3 articles) Friedemann Paul
    3. (2 articles) UCSF
    4. (2 articles) UT Southwestern Medical Center
    5. (2 articles) University Hospital Zurich
    6. (2 articles) Peter A. Calabresi
    7. (2 articles) Timm Oberwahrenbrock
    8. (1 articles) Heinrich-Heine University Düsseldorf
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    Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography Retinal Nerve Fiber Layer Thickness and Total Macular Volume in Multiple Sclerosis Subtypes and Their Relationship with Severity of Disease, a Cross-Sectional Study Noninvasive optical coherence tomography imaging correlates with anatomic and physiologic end-organ changes in healthy normotensives with systemic blood pressure variability OCT Angiography Features of Neovascularization as Predictive Factors for Frequent Recurrence in Age-Related Macular Degeneration Fast Track Diagnosis of Skin Cancer by Advanced Imaging Ticagrelor versus clopidogrel in patients undergoing implantation of paclitaxel-eluting stent in the femoropopliteal district: A randomized pilot study using frequency-domain optical coherence tomography Accuracy of intraocular lens power calculation formulas using a swept-source optical biometer Optical rotary junction incorporating a hollow shaft DC motor for high-speed catheter-based optical coherence tomography High-throughput dark-field full-field optical coherence tomography