1. Articles from F. Paul

    1-4 of 4
    1. Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

      Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

      Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber ...

      Read Full Article
    2. Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

      Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

      Background and purpose Some 3%−10% of patients with multiple sclerosis (MS) experience disease onset before the age of 18 years (‘early’ onset MS, EOMS). Optical coherence tomography is a non-invasive method to measure retinal nerve fibre layer thickness (RNFLT) and total macular volume (TMV) and may be useful to differentiate axonal and neuronal damage in the retina of patients with a history of EOMS. Here RNFLT and TMV in EOMS patients after a mean disease duration of 11.6 years were compared with patients with age- or disease-duration-matched later onset MS (LOMS) and healthy controls (HCs). Methods In this ...

      Read Full Article
    3. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. Objective: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. Methods: A prospective multi-centre ( n = 13) study. Peripapillary ring scan QC rating of an OCT training set ( n = 50) was followed by a test set ( n = 50). Inter-rater agreement was calculated using kappa statistics. Results were ...

      Read Full Article
    4. Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis

      Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis

      Background and purpose In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) – with its potential to reveal neuroaxonal retinal damage – may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity. Methods Seventy-six ALS patients (144 eyes) and 54 ...

      Read Full Article
    1-4 of 4
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (3 articles) Johns Hopkins University
    2. (3 articles) Friedemann Paul
    3. (2 articles) UCSF
    4. (2 articles) UT Southwestern Medical Center
    5. (2 articles) University Hospital Zurich
    6. (2 articles) Peter A. Calabresi
    7. (2 articles) Timm Oberwahrenbrock
    8. (2 articles) FDA
    9. (1 articles) Heinrich-Heine University Düsseldorf
    10. (1 articles) Fiona E. Costello
    11. (1 articles) Axel Petzold
    12. (1 articles) California Institute of Technology
    13. (1 articles) National Institutes of Health
    14. (1 articles) UC Irvine
    15. (1 articles) Brian K. Courtney
    16. (1 articles) Conavi Medical Inc.
  3. Popular Articles

  4. Picture Gallery

    Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography Beating Cancer - One Patient at a Time Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market Capsule Endomicroscopy for Visualization of the Small Intestine in EED Population in Pakistan Three-dimensional detection and quantification of defects in SiC by optical coherence tomography University of Illinois at Chicago Receives NIH Grant for Functional Tomography of Neurovascular Coupling Interactions in Healthy and Diseased Retinas Dyad Medical Receives NIH Grant for Software For OCT Analysis of Vascular Stents Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases Optical coherence tomography and fractional flow reserve guided treatment of woven coronary artery anomaly presenting as acute myocardial infarction