1. Articles from Kristin M. Poole

    1-3 of 3
    1. Quantifying the vascular response to ischemia with speckle variance optical coherence tomography

      Quantifying the vascular response to ischemia with speckle variance optical coherence tomography

      Longitudinal monitoring techniques for preclinical models of vascular remodeling are critical to the development of new therapies for pathological conditions such as ischemia and cancer. In models of skeletal muscle ischemia in particular, there is a lack of quantitative, non-invasive and long term assessment of vessel morphology. Here, we have applied speckle variance optical coherence tomography (OCT) methods to quantitatively assess vascular remodeling and growth in a mouse model of peripheral arterial disease. This approach was validated on two different mouse strains known to have disparate rates and abilities of recovering following induction of hind limb ischemia. These results establish ...

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    2. Longitudinal study of arteriogenesis with swept source optical coherence tomography and hyperspectral imaging

      Longitudinal study of arteriogenesis with swept source optical coherence tomography and hyperspectral imaging

      Peripheral arterial disease (PAD) is an atherosclerotic disease of the extremities that leads to high rates of myocardial infarction and stroke, increased mortality, and reduced quality of life. PAD is especially prevalent in diabetic patients, and is commonly modeled by hind limb ischemia in mice to study collateral vessel development and test novel therapies. Current techniques used to assess recovery cannot obtain quantitative, physiological data non-invasively. Here, we have applied hyperspectral imaging and swept source optical coherence tomography (OCT) to study longitudinal changes in blood oxygenation and vascular morphology, respectively, intravitally in the diabetic mouse hind limb ischemia model. Additionally ...

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    3. Optical coherence tomography and hyperspectral imaging of vascular recovery in a model of peripheral arterial disease

      Optical coherence tomography and hyperspectral imaging of vascular recovery in a model of peripheral arterial disease

      Peripheral arterial disease (PAD) leads to an increased risk of myocardial infarction and stroke, increased mortality, and reduced quality of life. The mouse hind limb ischemia (HLI) model is the most commonly used system for studying the mechanisms of collateral vessel formation and for testing new PAD therapies, but there is a lack of techniques for acquiring physiologically-relevant, quantitative data intravitally in this model. In this work, non-invasive, quantitative optical imaging techniques were applied to the mouse HLI model over a time course. Optical coherence tomography (OCT) imaged changes in blood flow (Doppler OCT) and microvessel morphology (speckle variance OCT ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Vanderbilt University
    2. (3 articles) Melissa C. Skala
    3. (2 articles) Chetan A. Patil
    4. (2 articles) National Institutes of Health
    5. (1 articles) Case Western Reserve University
    6. (1 articles) Zhejiang University
    7. (1 articles) Duke University
    8. (1 articles) University of Washington
    9. (1 articles) Michael W. Jenkins
    10. (1 articles) Zhihua Ding
    11. (1 articles) Andrew M. Rollins
    12. (1 articles) Joseph A. Izatt
    13. (1 articles) Peng Li
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