1. Articles from Su-Chin Shen

    1-6 of 6
    1. In vivo detection of UV-induced acute skin effects using optical coherence tomography

      In vivo detection of UV-induced acute skin effects using optical coherence tomography

      Ultraviolet (UV) rays have been identified as a carcinogen with long-term irradiation and are an important risk factor for skin cancer. Here, we report the use of optical coherence tomography/optical coherence tomography angiography (OCT/OCTA) to study acute UV-induced effects on skin in vivo . To understand the relationship between the acute effects and irradiated UV power density, three groups were irradiated with different power densities in our experiments. Furthermore, the same skin area was repeatedly scanned with OCT during UV irradiation to investigate the progress of the induced acute effects and after irradiation for observation of skin recovery. Subsequently ...

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    2. Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO 2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. We utilized optical coherence tomography (OCT) for real-time monitoring of the laser–skin tissue interaction, sparing the patient from an invasive surgical sampling procedure. The time-dependent OCT intensity variance was ...

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    3. Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography

      Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography

      Fractional resurfacing creates hundreds of microscopic wounds in the skin without injuring surrounding tissue. This technique allows rapid wound healing owing to small injury regions, and has been proven as an effective method for repairing photodamaged skin. Recently, ablative fractional laser (AFL) treatment has been demonstrated to facilitate topical drug delivery into skin. However, induced fractional photothermolysis depends on several parameters, such as incident angle, exposure energy, and spot size of the fractional laser. In this study, we used fractional CO 2 laser to induce microscopic ablation array on the nail for facilitating drug delivery through the nail. To ensure ...

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    4. Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Fractional photothermolysis induced by non-ablative fractional lasers (NAFLs) or ablative fractional lasers (AFLs) can remodel the skin, regenerate collagen, and remove tumor tissue. However, fractional laser treatments may result in severe side effects, and multiple treatments are required to achieve the expected outcome. Thus, the treatment outcome and downtime after fractional laser treatments are key issues to determine the following treatment strategy. In this study, an optical coherence tomography (OCT) system was implemented for in vivo studies of wound healing after NAFL and AFL treatments. According to the OCT scanning results, the laser-induced photothermolysis including volatilization and coagulation could be ...

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    5. Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Fractional photothermolysis induced by non-ablative fractional lasers (NAFLs) or ablative fractional lasers (AFLs) can remodel the skin, regenerate collagen, and remove tumor tissue. However, fractional laser treatments may result in severe side effects, and multiple treatments are required to achieve the expected outcome. Thus, the treatment outcome and downtime after fractional laser treatments are key issues to determine the following treatment strategy. In this study, an optical coherence tomography (OCT) system was implemented for in vivo studies of wound healing after NAFL and AFL treatments. According to the OCT scanning results, the laser-induced photothermolysis including volatilization and coagulation could be ...

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    6. Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography

      Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography

      In this study, time-resolved optical coherence tomography (OCT) scanning images of the process of water diffusion in the skin that illustrate the enhancement in the backscattered intensities due to the increased water concentration are presented. In our experiments, the water concentration in the skin was increased by soaking the hand in water, and the same region of the skin was scanned and measured with the OCT system and a commercial moisture monitor every three minutes. To quantitatively analyze the moisture-related optical properties and the velocity of water diffusion in human skin, the attenuation coefficients of the skin, including the epidermis ...

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    1-6 of 6
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    1. (6 articles) Chang Gung University
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    Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography Feasibility of ablative fractional laser-assisted drug delivery with optical coherence tomography Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography In vivo detection of UV-induced acute skin effects using optical coherence tomography Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy Thickness of retinal pigment epithelium–Bruch’s membrane complex in adult Chinese using optical coherence tomography Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography Microperimetry, Humphrey field analyzer, and optical coherence tomography in detecting glaucoma: a comparative performance study