1. Articles from Zhichao Wu

    1-13 of 13
    1. Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images

      Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images

      Purpose : Relative ellipsoid zone reflectivity (rEZR) represents a potential biomarker of photoreceptor health on spectral-domain optical coherence tomography (SD-OCT). Because manual quantification of rEZR is laborious and lacks of spatial resolution, automated quantification of the rEZR would be beneficial. The purpose of this study was to evaluate the reliability and reproducibility of an automated rEZR quantification method. Methods : The rEZR was acquired using a manual and an automated approach in eyes with age-related macular degeneration (AMD) and healthy controls. The rEZR obtained from both methods was compared and the agreement between the methods and their reproducibility assessed. Results : Forty eyes ...

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    2. Predicting Progression of Age-Related Macular Degeneration Using Optical Coherence Tomography and Fundus Photography

      Predicting Progression of Age-Related Macular Degeneration Using Optical Coherence Tomography and Fundus Photography

      Purpose To compare the performance of automatically quantified optical coherence tomography (OCT) imaging biomarkers and conventional risk factors manually graded on color fundus photographs (CFP) for predicting progression to late age-related macular degeneration (AMD). Design Longitudinal observational study. Participants 280 eyes from 140 participants with bilateral large drusen. Methods All participants underwent OCT and CFP imaging at baseline and were then reviewed at six-monthly intervals to determine progression to late AMD. CFPs were manually graded and OCT scans underwent automated image analyses to quantify risk factors and imaging biomarkers respectively based on drusen and AMD pigmentary abnormalities. Four predictive models ...

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    3. A Topographic Comparison of OCT Minimum rim Width (BMO-MRW) and Circumpapillary Retinal nerve Fiber Layer (cRNFL) Thickness Measures in Eyes with or Suspected Glaucoma

      A Topographic Comparison of OCT Minimum rim Width (BMO-MRW) and Circumpapillary Retinal nerve Fiber Layer (cRNFL) Thickness Measures in Eyes with or Suspected Glaucoma

      Précis: Bruch’s membrane opening-minimum rim width and circumpapillary retinal nerve fiber layer thickness measures may be improved by comparing probability levels and accounting for blood vessel locations. Purpose: To understand the differences between two optical coherence tomography (OCT) measures of glaucomatous damage: the Bruch’s membrane opening-minimum rim width ( BMO-MRW ) and circumpapillary retinal nerve fiber layer (cRNFL) thickness. Materialsand Methods: OCT circle scans were obtained for an early glaucoma group (EG) of 88 eyes (88 patients) with 24-2 MD better than –6.0dB, and a broader group (BG) of 188 eyes (110 patients) with 24-2 MD from -0 ...

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    4. Sample Size Requirements of Glaucoma Clinical Trials When Using Combined Optical Coherence Tomography and Visual Field Endpoints

      Sample Size Requirements of Glaucoma Clinical Trials When Using Combined Optical Coherence Tomography and Visual Field Endpoints

      Glaucoma clinical trials using visual field (VF) endpoints currently require large sample sizes because of the slowly-progressive nature of this disease. We sought to examine whether the combined use of VF testing and non-invasive optical coherence tomography (OCT) imaging of the neuroretinal tissue could improve the feasibility of such trials. To examine this, we included 192 eyes of 121 glaucoma participants seen at ≥5 visits over a 2-year period to extract real-world estimates of the rates of change and variability of VF and OCT imaging measurements for computer simulations to obtain sample size estimates. We observed that the combined use ...

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    5. Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage

      Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage

      Purpose To understand the added value of Bruch’s membrane opening-minimum rim width (BMO-MRW) measurements to conventional circumpapillary retinal nerve fibre layer (cpRNFL) thickness measurements on optical coherence tomography (OCT) imaging for discriminating between perimetric glaucoma and healthy eyes, evaluated through a qualitative evaluation. Methods 384 healthy eyes and 188 glaucoma eyes were evaluated, and glaucoma eyes were categorised as perimetric (n=107) based on a history of ≥3 consecutive abnormal 24–2 visual field tests or suspected glaucoma if they did not (n=81). OCT-derived BMO-MRW and cpRNFL reports were qualitatively evaluated by two experienced graders in isolation at ...

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    6. Comparison of Widefield and Circumpapillary Circle Scans for Detecting Glaucomatous Neuroretinal Thinning on Optical Coherence Tomography

      Comparison of Widefield and Circumpapillary Circle Scans for Detecting Glaucomatous Neuroretinal Thinning on Optical Coherence Tomography

      Purpose : Our purpose was to compare the effectiveness of detecting progressive retinal nerve fiber layer (RNFL) thickness changes using widefield scans compared to circumpapillary circle scans derived from optic disc volume scans when using a manual region-of-interest (ROI) approach . Methods : In a prospective observational study, a total of 125 eyes diagnosed clinically with glaucoma or suspected glaucoma that had both widefield (12 × 9 mm) and optic disc (6 × 6 mm) scans obtained at least one year apart were included. Changes in the RNFL thickness between the two visits were evaluated within region(s) of observed or suspected glaucomatous damage, which ...

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    7. Evaluation of a Qualitative Approach for Detecting Glaucomatous Progression Using Wide-Field Optical Coherence Tomography Scans

      Evaluation of a Qualitative Approach for Detecting Glaucomatous Progression Using Wide-Field Optical Coherence Tomography Scans

      Purpose : To determine the effectiveness of detecting glaucomatous progression by a qualitative evaluation of wide-field (12 × 9 mm) scans on optical coherence tomography imaging. This method was compared to a conventional quantitative analysis of the global circumpapillary retinal nerve fiber layer (cpRNFL) thickness. Methods : A total of 409 eyes with a clinical diagnosis of glaucoma or suspected glaucoma for which two wide-field scans were obtained at least 1 year apart ( n = 125) and within one session ( n = 284) were included to determine the sensitivity of detecting progression at 95% specificity. Qualitative OCT evaluation was performed in a similar manner to ...

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    8. Evaluation of a Region-of-Interest Approach for Detecting Progressive Glaucomatous Macular Damage on Optical Coherence Tomography

      Evaluation of a Region-of-Interest Approach for Detecting Progressive Glaucomatous Macular Damage on Optical Coherence Tomography

      Purpose : To evaluate a manual region-of-interest (ROI) approach for detecting progressive macular ganglion cell complex (GCC) changes on optical coherence tomography (OCT) imaging. Methods : One hundred forty-six eyes with a clinical diagnosis of glaucoma or suspected glaucoma with macular OCT scans obtained at least 1 year apart were evaluated. Changes in the GCC thickness were identified using a manual ROI approach (ROI M ), whereby region(s) of observed or suspected glaucomatous damage were manually identified when using key features from the macular OCT scan on the second visit. Progression was also evaluated using the global GCC thickness and an automatic ...

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    9. Detecting Glaucomatous Progression With a Region-of-Interest Approach on Optical Coherence Tomography: A Signal-to-Noise Evaluation

      Detecting Glaucomatous Progression With a Region-of-Interest Approach on Optical Coherence Tomography: A Signal-to-Noise Evaluation

      Purpose : To compare two region-of-interest (ROI) approaches and a global thickness approach for capturing progressive circumpapillary retinal nerve fiber layer (cpRNFL) changes on optical coherence tomography (OCT) imaging. Methods : Progressive cpRNFL thickness changes were evaluated in 164 eyes with a clinical diagnosis of glaucoma or suspected glaucoma; all eyes underwent optic disc OCT imaging on two visits at least 1 year apart. Such changes were evaluated with a manual ROI approach (ROI M ), which involved manual identification of region(s) of observed or suspected glaucomatous damage. The ROI M was compared with an automatic ROI approach (ROI A ), where regions ...

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    10. Ellipsoid zone on optical coherence tomography: a review

      Ellipsoid zone on optical coherence tomography: a review

      Emergence of the high-resolution optical coherence tomography has allowed better delineation of retinal layers and many of the anatomical correlations of these layers have now been agreed upon. However some anatomical correlates still remain contentious, such as the second hyper-reflective band which is now termed ellipsoid zone. Despite the lack of consensus of the actual origin of the ellipsoid zone, there has been much interest in evaluating its integrity and intensity in different disease processes. This review paper aims to provide an overview of the ellipsoid zone and its clinical and research applications.

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    11. Optical Coherence Tomography–Defined Changes Preceding the Development of Drusen-Associated Atrophy in Age-Related Macular Degeneration

      Optical Coherence Tomography–Defined Changes Preceding the Development of Drusen-Associated Atrophy in Age-Related Macular Degeneration

      Purpose To characterize the pathological changes preceding the development of drusen-associated atrophy in eyes with age-related macular degeneration (AMD) using spectral-domain optical coherence tomography (SD-OCT). Design Longitudinal and cross-sectional retrospective observational study. Participants A total of 181 participants with intermediate AMD in at least 1 eye (141 unilateral, 40 bilateral) were assessed longitudinally. A total of 230 participants with bilateral intermediate AMD (40 longitudinal participants with an additional 190 participants) were analyzed cross-sectionally. Methods Spectral-domain OCT, color fundus photography (CFP), near-infrared reflectance, and fundus autofluorescence imaging were performed in all participants at cross-section and every 3 months for up to ...

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    12. Relationship between Retinal Microstructures on Optical Coherence Tomography and Microperimetry in Age-Related Macular Degeneration

      Relationship between Retinal Microstructures on Optical Coherence Tomography and Microperimetry in Age-Related Macular Degeneration

      Purpose: To determine the relationship between structural parameters of the outer retina on spectral-domain optical coherence tomography (SD-OCT) and microperimetric retinal sensitivity in early stages of age-related macular degeneration (AMD).Design: Prospective, observational study.Participants: Seventy-five eyes of 75 participants with early stages of AMD (drusen ≥125 μm, with/without pigmentary abnormalities) and 25 control participants of a similar age.Methods: Participants underwent microperimetry testing and high-resolution SD-OCT scans. Structural parameters at 5 central points (0°, 1°, and 2.33° nasal and temporal to the fovea along the horizontal axis) corresponding to areas tested by microperimetry were compared. Structural parameters ...

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    13. Relationship Between the Second Reflective Band on Optical Coherence Tomography and Multifocal Electroretinography in Age-Related Macular Degeneration

      Relationship Between the Second Reflective Band on Optical Coherence Tomography and Multifocal Electroretinography in Age-Related Macular Degeneration

      Purpose: The second hyper-reflective on spectral domain optical coherence tomography (SD-OCT) has been suggested to correlate with the photoreceptor inner segment ellipsoids (ISe). The purpose of this study was to determine the relationship between the intensity of the ISe band and retinal function measured by multifocal electroretinography (mfERG) in patients with early age-related macular degeneration (AMD). Methods: A high-resolution horizontal line-scan through the fovea on SD-OCT and a mfERG recording were performed in one eye of 29 early AMD and 31 control participants. The relative intensity of the ISe band within 1000µm of the fovea was quantified using ImageJ ...

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    1-13 of 13
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    1. (7 articles) University of Melbourne
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    Relationship Between the Second Reflective Band on Optical Coherence Tomography and Multifocal Electroretinography in Age-Related Macular Degeneration Relationship between Retinal Microstructures on Optical Coherence Tomography and Microperimetry in Age-Related Macular Degeneration Optical Coherence Tomography–Defined Changes Preceding the Development of Drusen-Associated Atrophy in Age-Related Macular Degeneration Ellipsoid zone on optical coherence tomography: a review Detecting Glaucomatous Progression With a Region-of-Interest Approach on Optical Coherence Tomography: A Signal-to-Noise Evaluation Evaluation of a Region-of-Interest Approach for Detecting Progressive Glaucomatous Macular Damage on Optical Coherence Tomography Evaluation of a Qualitative Approach for Detecting Glaucomatous Progression Using Wide-Field Optical Coherence Tomography Scans Comparison of Widefield and Circumpapillary Circle Scans for Detecting Glaucomatous Neuroretinal Thinning on Optical Coherence Tomography Qualitative evaluation of neuroretinal rim and retinal nerve fibre layer on optical coherence tomography to detect glaucomatous damage Predicting Progression of Age-Related Macular Degeneration Using Optical Coherence Tomography and Fundus Photography Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections