1. Articles from Mark J. Mannis

    1-7 of 7
    1. In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1μm swept source phase-variance optical coherence angiography

      In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1μm swept source phase-variance optical coherence angiography

      We present in vivo volumetric depth-resolved vasculature images of the anterior segment of the human eye acquired with phase-variance based motion contrast using a high-speed (100 kHz, 10 5 A-scans/s) swept source optical coherence tomography system (SSOCT). High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. The human corneo–scleral junction and sclera were imaged with swept source phase-variance optical coherence angiography and compared with slit lamp images from the same eyes of normal subjects. Different features of the rich vascular system in the conjunctiva and episclera were visualized and described. This system ...

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    2. In vivo evaluation of the cornea and conjunctiva of the normal laboratory beagle using time- and Fourier-domain optical coherence tomography and ultrasound pachymetry

      In vivo evaluation of the cornea and conjunctiva of the normal laboratory beagle using time- and Fourier-domain optical coherence tomography and ultrasound pachymetry

      Objective To obtain normative data for the canine cornea and conjunctiva using high-resolution time- and Fourier-domain optical coherence tomography (TD-OCT and FD-OCT) and ultrasound pachymetry (USP). Animals One hundred sixty-eight eyes of 133 healthy young intact laboratory beagles. Procedures The cornea and conjunctiva of 16 eyes of 8 healthy young intact female beagles were imaged using FD-OCT. Corneal thickness was measured with FD-OCT and USP, while corneal epithelial thickness and conjunctival epithelial thickness were measured with FD-OCT. The central corneal thickness (CCT) was determined in 152 eyes of 125 healthy young adult intact female (35) and male (90) beagles using ...

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    3. Epithelial Downgrowth After Penetrating Keratoplasty: Imaging by High-Resolution Optical Coherence Tomography and In Vivo Confocal Microscopy

      Epithelial Downgrowth After Penetrating Keratoplasty: Imaging by High-Resolution Optical Coherence Tomography and In Vivo Confocal Microscopy

      Purpose: To report the clinical utility of high-resolution anterior segment optical coherence tomography (AS-OCT) combined with in vivo confocal microscopy (IVCM) to diagnose and follow the effectiveness of treatment of 2 cases of epithelial downgrowth after penetrating keratoplasty. Methods: A retrospective case review was performed on 2 eyes of 2 patients with a history of multiple penetrating keratoplasties that developed epithelial downgrowth 4 and 6 months after the most recent penetrating graft. At various time points, high-resolution AS-OCT images were obtained using the Spectralis (Heidelberg Engineering GmbH), and IVCM images were obtained using the Heidelberg Retina Tomograph III Rostock Cornea ...

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    4. Three-dimensional anterior segment imaging in patients with type 1 Boston Keratoprosthesis with switchable full depth range swept source optical coherence tomography

      Three-dimensional anterior segment imaging in patients with type 1 Boston Keratoprosthesis with switchable full depth range swept source optical coherence tomography

      A high-speed (100 kHz A - scans / s ) complex conjugate resolved 1 μ m swept source optical coherence tomography (SS-OCT) system using coherence revival of the light source is suitable for dense three-dimensional (3-D) imaging of the anterior segment. The short acquisition time helps to minimize the influence of motion artifacts. The extended depth range of the SS-OCT system allows topographic analysis of clinically relevant images of the entire depth of the anterior segment of the eye. Patients with the type 1 Boston Keratoprosthesis (KPro) require evaluation of the full anterior segment depth. Current commercially available OCT systems are not suitable for ...

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    5. High-Resolution Spectral Domain Anterior Segment Optical Coherence Tomography in Type 1 Boston Keratoprosthesis

      High-Resolution Spectral Domain Anterior Segment Optical Coherence Tomography in Type 1 Boston Keratoprosthesis

      Purpose: To report the results of imaging using high-resolution, Fourier domain anterior segment optical coherence tomography (AS-OCT) to evaluate patients with a type 1 Boston Keratoprosthesis (KPro). Methods: We performed a retrospective comparative study of patients in whom we implanted the Boston KPro. A total of 26 eyes of 23 patients from the Cornea Service at the University of California Davis Eye Center were included. Subjects were evaluated with the Spectralis AS-OCT (Heidelberg Engineering GmbH). Results: Preoperative diagnoses for KPro surgery included failed corneal transplant (69%), chemical burn (23%), and aniridia (8%). The average age of patients was 63.2 ...

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    6. Application of full range swept source optical coherence tomography for imaging of the anterior eye segment in patients with type I Boston Keratoprosthesis

      Application of full range swept source optical coherence tomography for imaging of the anterior eye segment in patients with type I Boston Keratoprosthesis

      We present a high-speed complex conjugate resolved 1 μm swept source optical coherence tomography [SS-OCT] system using coherence revival of the light source for clinical imaging of the anterior segment of the eye. High-speed of 100,000 A-scans/sec and 1 μm imaging window of OCT permits dense 3D imaging of the anterior segment, minimizing the influence of motion artifacts and deep penetration of images for topographic analysis. The swept laser performance with internal clocking was adapted to achieve extended imaging depth requirements. The feasibility of our instrument for visualization of the anterior segment of patients with the Boston Keratoprosthesis ...

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    7. Anterior Segment OCT and Confocal Microscopy Findings in Atypical Corneal Intraepithelial Neoplasia

      Anterior Segment OCT and Confocal Microscopy Findings in Atypical Corneal Intraepithelial Neoplasia

      Purpose: To report a case of biopsy-proven corneal intraepithelial neoplasia (CIN) diagnosed and followed clinically using high-resolution anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM). Methods: Observational case report. Results: A 57-year-old man presented with decreased vision in the right eye for 2 months before presentation. His best-corrected visual acuity was 20/70 in the affected eye, and the slit-lamp examination revealed superficial opacification of the anterior cornea originating from the temporal limbus with a "leopard-spot" pattern more centrally. The lesion was excised at his 2-month follow-up, and the histological examination revealed squamous dysplasia consistent with ...

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    1-7 of 7
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  2. Topics in the News

    1. (4 articles) UC Davis
    2. (4 articles) John S. Werner
    3. (3 articles) Robert J. Zawadzki
    4. (2 articles) Raju Poddar
    5. (1 articles) University of Wisconsin
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    Anterior Segment OCT and Confocal Microscopy Findings in Atypical Corneal Intraepithelial Neoplasia Application of full range swept source optical coherence tomography for imaging of the anterior eye segment in patients with type I Boston Keratoprosthesis High-Resolution Spectral Domain Anterior Segment Optical Coherence Tomography in Type 1 Boston Keratoprosthesis Three-dimensional anterior segment imaging in patients with type 1 Boston Keratoprosthesis with switchable full depth range swept source optical coherence tomography Epithelial Downgrowth After Penetrating Keratoplasty: Imaging by High-Resolution Optical Coherence Tomography and In Vivo Confocal Microscopy In vivo evaluation of the cornea and conjunctiva of the normal laboratory beagle using time- and Fourier-domain optical coherence tomography and ultrasound pachymetry In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1μm swept source phase-variance optical coherence angiography In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography Negative Vessel Remodeling in Stargardt Disease Quantified with Volume-Rendered Optical Coherence Tomography Angiography Spectral Domain – Optical Coherence Tomography findings in Triple-A Syndrome – A case series from Pakistan Feasibility of microscope-integrated swept-source optical coherence tomography in canaloplasty A preliminary study of post-progressive nail-art effects on in vivo nail plate using optical coherence tomography-based intensity profiling assessment