1. Articles from Sharon Fekrat

    1-5 of 5
    1. Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants

      Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants

      Purpose Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared. Design Cross-sectional study. Participants Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled. Methods Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination. Main Outcome Measures Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic ...

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    2. Assessment of Differences in Retinal Microvasculature Using OCT Angiography in Alzheimer's Disease: A Twin Discordance Report

      Assessment of Differences in Retinal Microvasculature Using OCT Angiography in Alzheimer's Disease: A Twin Discordance Report

      The authors report the optical coherence tomography angiography (OCTA)-based comparative assessment of the retinal microvasculature in a rare pair of 96-year-old female monozygotic twins discordant for Alzheimer's disease (AD). Using automated mapping of the superficial capillary plexus, the authors observed that the twin with advanced AD had a significantly reduced vessel density and a larger foveal avascular zone in the superficial capillary plexus as well as a thinner choroid compared to the twin who was cognitively normal. This unique twin discordance report adds to the evidence supporting the use of retinal microvasculature changes in the superficial capillary plexus ...

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    3. Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy

      Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy

      Paracentral acute middle maculopathy (PAMM) has been described as a hyperreflective band or plaque-like region on spectral-domain optical coherence tomography (SD-OCT) at the level of the inner nuclear layer (INL), which is straddled by the intermediate and deep retinal capillary plexuses. 1,2 PAMM has been reported to cause eccentric wedge-shaped lesions that extend to the edge of the foveal avascular zone. 3 Although these lesions resolve over time, patients are left with irreversible INL atrophy, resulting in a permanent paracentral visual field defect.

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    4. Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy

      Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy

      A 57-year-old white woman developed autoimmune retinopathy (AIR) in both eyes associated with bilateral autoimmune sensorineural hearing loss. Laboratory testing was positive for 68kDa (heat-shock protein) and 136kDa (human interstitial retinoid-binding protein). Extensive cancer screening was negative. Spectral-domain optical coherence tomography enhanced depth imaging demonstrated a markedly thickened choroid in both eyes. En face imaging showed a distinctive pattern of granular hyperreflective foveal dots. The concurrent sensorineural hearing loss was thought to be of autoimmune origin and also responded to immunosuppressive treatment. Eyes with non-paraneoplastic, seropositive AIR may have associated increased choroidal thickness. Audiology testing should be considered.

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      Mentions: Duke University
    5. Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device

      Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device

      Purpose: The authors have recently developed a high-resolution microscope-integrated spectral domain optical coherence tomography (MIOCT) device designed to enable OCT acquisition simultaneous with surgical maneuvers. The purpose of this report is to describe translation of this device from preclinical testing into human intraoperative imaging. Methods: Before human imaging, surgical conditions were fully simulated for extensive preclinical MIOCT evaluation in a custom model eye system. Microscope-integrated spectral domain OCT images were then acquired in normal human volunteers and during vitreoretinal surgery in patients who consented to participate in a prospective institutional review board-approved study. Microscope-integrated spectral domain OCT images were obtained ...

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    1-5 of 5
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  2. Topics in the News

    1. (3 articles) Duke University
    2. (3 articles) National Institutes of Health
    3. (1 articles) Anthony N. Kuo
    4. (1 articles) Cynthia A. Toth
    5. (1 articles) Joseph A. Izatt
    6. (1 articles) Paul V. Hahn
    7. (1 articles) Leica
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    9. (1 articles) University of Pennsylvania
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    11. (1 articles) Harbin Medical University
    12. (1 articles) University of Iowa
    13. (1 articles) Yan Wang
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    15. (1 articles) Bo Yu
    16. (1 articles) Alcon
    17. (1 articles) Canon Medical Systems
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    Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy Assessment of Differences in Retinal Microvasculature Using OCT Angiography in Alzheimer's Disease: A Twin Discordance Report Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants Vitreous Seeding in Retinocytoma: Importance of Optical Coherence Tomography Utility of Spectral-Domain Optical Coherence Tomography in Differentiating Papilledema From Pseudopapilledema: A Prospective Longitudinal Study Visualizing and quantifying cutaneous microvascular reactivity in humans using optical coherence tomography: Impaired dilator function in diabetes Optical Coherence Tomography of Outer Retinal Hyper-Reflectivity, Neovascularization and Pigment in Type 2 Macular Telangiectasia Early Detection of Incipient Retinal Pigment Epithelium Atrophy Overlying Drusen with Fundus Autofluorescence vs. Spectral Domain Optical Coherence Tomography Association of ABO blood groups and non-culprit plaque characteristics in acute coronary syndrome: an optical coherence tomography study Don't be afraid of the dark - OCT angiography through a black intraocular lens