1. Articles from Sharon Fekrat

    1-10 of 10
    1. Assessment of Retinal Microvascular Alterations in Individuals with Amnestic and Non-Amnestic Mild Cognitive Impairment using Optical Coherence Tomography Angiography

      Assessment of Retinal Microvascular Alterations in Individuals with Amnestic and Non-Amnestic Mild Cognitive Impairment using Optical Coherence Tomography Angiography

      Purpose: To assess retinal microvascular alterations in individuals with amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: One hundred and twelve eyes of 59 amnestic MCI participants, 32 eyes of 17 non-amnestic MCI participants, and 111 eyes of 56 controls with normal cognition were included. Optical coherence tomography angiography (OCTA) vessel density (VD) and perfusion density (PD) in the Early Treatment Diabetic Retinopathy Study (ETDRS) 3mm circle and ring were assessed. Retinal thickness parameters including retinal nerve fiber layer (RNFL) thickness, ganglion cell-inner plexiform layer (GC-IPL) thickness, central subfield thickness (CST), and choroidal parameters including subfoveal choroidal thickness (SFCT ...

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      Mentions: Duke University
    2. Reproducibility of Retinal Vascular Phenotypes Obtained with Optical Coherence Tomography Angiography: Importance of Vessel Segmentation

      Reproducibility of Retinal Vascular Phenotypes Obtained with Optical Coherence Tomography Angiography: Importance of Vessel Segmentation

      Optical coherence tomography angiography (OCTA) is a non-invasive imaging method that can visualize the finest vascular networks in the human retina. OCTA image analysis has been successfully applied to the investigation of retinal vascular diseases of the eye and other systemic conditions that may manifest in the eye. To characterize and distinguish OCTA images from different pathologies, it is important to identify quantitative metrics and phenotypes that have high reproducibility and are not overly susceptible to the effects of imaging artifacts. This paper demonstrates the reproducibility of several recently demonstrated candidate OCTA quantitative metrics: mean curvature and tortuosity of the ...

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      Mentions: Duke University
    3. Identifying peripapillary radial capillary plexus alterations in Parkinson's disease using optical coherence tomography angiography

      Identifying peripapillary radial capillary plexus alterations in Parkinson's disease using optical coherence tomography angiography

      Purpose: To compare radial peripapillary capillary plexus vascular parameters and retinal nerve fiber layer (RNFL) thickness between Parkinson's disease (PD) and controls. Design: Prospective cross-sectional study. Participants: One hundred and fifty-one eyes of 81 PD participants and 514 eyes of 314 controls. Methods: Participants underwent optical coherence tomography (OCTA) imaging using the Zeiss Cirrus HD-5000 AngioPlex. Capillary perfusion density (CPD) and capillary flux index (CFI) were assessed using a 4.5x4.5 mm peripapillary scan, and RNFL thickness was assessed using a 200x200 μm optic nerve cube OCT scan. Hoehn and Yahr clinical staging for PD was determined by ...

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    4. The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review

      The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review

      Introduction Discovering non‐invasive and easily acquired biomarkers that are conducive to the accurate diagnosis of dementia is an urgent area of ongoing clinical research. One promising approach is retinal imaging, as there is homology between retinal and cerebral vasculature. Recently, optical coherence tomography angiography (OCT‐A) has emerged as a promising new technology for imaging the microvasculature of the retina. Methods A systematic review and meta‐analysis was conducted to examine the application of OCT‐A in dementia. Results Fourteen studies assessing OCT‐A in preclinical Alzheimer's disease (AD), mild cognitive impairment, or AD were included. Exploratory meta ...

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    5. Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults

      Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults

      Purpose: This work assesses the intrasession repeatability of capillary perfusion density (CPD) and capillary flux index (CFI) measurements on peripapillary optical coherence tomography angiography (OCTA) in healthy eyes of older adults. Methods: In this cross-sectional study, healthy volunteers aged 50 years or older underwent 4.5 × 4.5 mm OCTA imaging centered on the optic nerve head using Zeiss Cirrus HD-5000 AngioPlex (Carl Zeiss Meditec). Two consecutive images were acquired in the same eye during a single study session. CPD and CFI were assessed using AngioPlex Software (version 11.0.0.29946) for the radial peripapillary capillary plexus (average over ...

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    6. Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants

      Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants

      Purpose Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer’s disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared. Design Cross-sectional study. Participants Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled. Methods Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination. Main Outcome Measures Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic ...

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    7. Assessment of Differences in Retinal Microvasculature Using OCT Angiography in Alzheimer's Disease: A Twin Discordance Report

      Assessment of Differences in Retinal Microvasculature Using OCT Angiography in Alzheimer's Disease: A Twin Discordance Report

      The authors report the optical coherence tomography angiography (OCTA)-based comparative assessment of the retinal microvasculature in a rare pair of 96-year-old female monozygotic twins discordant for Alzheimer's disease (AD). Using automated mapping of the superficial capillary plexus, the authors observed that the twin with advanced AD had a significantly reduced vessel density and a larger foveal avascular zone in the superficial capillary plexus as well as a thinner choroid compared to the twin who was cognitively normal. This unique twin discordance report adds to the evidence supporting the use of retinal microvasculature changes in the superficial capillary plexus ...

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    8. Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy

      Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy

      Paracentral acute middle maculopathy (PAMM) has been described as a hyperreflective band or plaque-like region on spectral-domain optical coherence tomography (SD-OCT) at the level of the inner nuclear layer (INL), which is straddled by the intermediate and deep retinal capillary plexuses. 1,2 PAMM has been reported to cause eccentric wedge-shaped lesions that extend to the edge of the foveal avascular zone. 3 Although these lesions resolve over time, patients are left with irreversible INL atrophy, resulting in a permanent paracentral visual field defect.

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    9. Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy

      Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy

      A 57-year-old white woman developed autoimmune retinopathy (AIR) in both eyes associated with bilateral autoimmune sensorineural hearing loss. Laboratory testing was positive for 68kDa (heat-shock protein) and 136kDa (human interstitial retinoid-binding protein). Extensive cancer screening was negative. Spectral-domain optical coherence tomography enhanced depth imaging demonstrated a markedly thickened choroid in both eyes. En face imaging showed a distinctive pattern of granular hyperreflective foveal dots. The concurrent sensorineural hearing loss was thought to be of autoimmune origin and also responded to immunosuppressive treatment. Eyes with non-paraneoplastic, seropositive AIR may have associated increased choroidal thickness. Audiology testing should be considered.

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      Mentions: Duke University
    10. Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device

      Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device

      Purpose: The authors have recently developed a high-resolution microscope-integrated spectral domain optical coherence tomography (MIOCT) device designed to enable OCT acquisition simultaneous with surgical maneuvers. The purpose of this report is to describe translation of this device from preclinical testing into human intraoperative imaging. Methods: Before human imaging, surgical conditions were fully simulated for extensive preclinical MIOCT evaluation in a custom model eye system. Microscope-integrated spectral domain OCT images were then acquired in normal human volunteers and during vitreoretinal surgery in patients who consented to participate in a prospective institutional review board-approved study. Microscope-integrated spectral domain OCT images were obtained ...

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    1-10 of 10
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    Preclinical Evaluation and Intraoperative Human Retinal Imaging With A High-Resolution Microscope-Integrated Spectral Domain Optical Coherence Tomography Device Choroidal Thickness and En Face Optical Coherence Tomography Imaging in Autoimmune Retinopathy Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy Assessment of Differences in Retinal Microvasculature Using OCT Angiography in Alzheimer's Disease: A Twin Discordance Report Retinal Microvascular and Neurodegenerative Changes in Alzheimer’s Disease and Mild Cognitive Impairment Compared with Control Participants Repeatability of Peripapillary Optical Coherence Tomography Angiography Parameters in Older Adults The application of optical coherence tomography angiography in Alzheimer's disease: A systematic review Identifying peripapillary radial capillary plexus alterations in Parkinson's disease using optical coherence tomography angiography Reproducibility of Retinal Vascular Phenotypes Obtained with Optical Coherence Tomography Angiography: Importance of Vessel Segmentation Assessment of Retinal Microvascular Alterations in Individuals with Amnestic and Non-Amnestic Mild Cognitive Impairment using Optical Coherence Tomography Angiography A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography