1. Articles from Can Duan

    1-11 of 11
    1. A miniature endoscopic optical coherence tomography probe based on C-lens

      A miniature endoscopic optical coherence tomography probe based on C-lens

      We present a novel miniature endoscopic OCT probe based on an electrothermal microelectromechanical (MEMS) mirror and a C-lens. The MEMS mirror has a relatively large mirror plate of 0.5 mm×0.5 mm on a small chip size of 1.5 mm×1.3 mm, leading to the outer diameter of the endoscopic probe down to only 2.5 mm so that the probe is capable of being inserted through the biopsy channel of a conventional endoscope. A long focal length of 12 mm is achieved by properly designing the C-lens. Compared to commonly used GRIN lenses, C-lenses have ...

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    2. Circumferential-scanning endoscopic optical coherence tomography probe based on a circular array of six 2-axis MEMS mirrors

      Circumferential-scanning endoscopic optical coherence tomography probe based on a circular array of six 2-axis MEMS mirrors

      We present a novel circumferential-scan endoscopic optical coherence tomography (OCT) probe by using a circular array of six electrothermal microelectromechanical (MEMS) mirrors and six C-lenses. The MEMS mirrors have a 0.5 mm × 0.5 mm mirror plate and a chip size of 1.5 mm × 1.3 mm. Each MEMS mirror can scan up to 45° at a voltage of less than 12 V. Six of those mirrors have been successfully packaged to a probe head; full circumferential scans have been demonstrated. Furthermore, each scan unit is composed of a MEMS mirror and a C-lens and the six scan ...

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      Mentions: Huikai K. Xie
    3. Miniature multimodal endoscopic probe based on double-clad fiber

      Miniature multimodal endoscopic probe based on double-clad fiber

      Optical coherence tomography (OCT) can obtain light scattering properties with a high resolution, while photoacoustic imaging (PAI) is ideal for mapping optical absorbers in biological tissues, and ultrasound (US) could penetrate deeply into tissues and provide elastically structural information. It is attractive and challenging to integrate these three imaging modalities into a miniature probe, through which, both optical absorption and scattering information of tissues as well as deep-tissue structure can be obtained. Here, we present a novel side-view probe integrating PAI, OCT and US imaging based on double-clad fiber which is used as a common optical path for PAI (light ...

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    4. Planar and Integrated MEMS Micromirrors Based Endoscopic Optical Coherence Tomography (Thesis)

      Planar and Integrated MEMS Micromirrors Based Endoscopic Optical Coherence Tomography (Thesis)

      Optical coherence tomography (OCT) is a thriving imaging modality which provides high-resolution, in vivo, real-time, non-invasive, cross-sectional imaging capability for biomedical applications. Over the past decade, OCT has become a standard clinical diagnosis tool for ophthalmology. However, human organs other than eyeballs are all highly scattering tissues, which limits the OCT penetration depth to ~2 mm. Therefore, endoscopic OCT probes with small diameter must be developed for imaging internal organs. The key component of an endoscopic OCT probe is the optical scanner. Thus, the first objective of this work is to develop miniature optical scanners using microelectromechanical system (MEMS) technology ...

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    5. Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe

      Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe

      This paper presents a common-path (CP) swept-source optical coherence tomography (SSOCT) system based on a special endoscopic probe design with an in-line internal reflection as the reference and a two-axis electrothermal microelectromechanical system mirror for image scanning. The rear surface of a gradient reflective index (GRIN) lens inside the probe is set as the reference reflection plane. The length of the GRIN lens is optimized to eliminate the artifacts in SSOCT images successfully. Doppler OCT is also demonstrated based on the CP endoscopic probe. The diameter of the probe is only 2.5 mm, so it can be easily inserted ...

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    6. Miniature probe integrating optical-resolution photoacoustic microscopy, optical coherence tomography, and ultrasound imaging: proof-of-concept

      Miniature probe integrating optical-resolution photoacoustic microscopy, optical coherence tomography, and ultrasound imaging: proof-of-concept

      In this Letter, we present a novel tri-modal miniature side-view probe, through which optical-resolution photoacoustic microscopy (OR-PAM), optical coherence tomography (OCT), and pulse-echo ultrasound (US) images can be coaxially acquired and displayed simultaneously. The probe consists of a common optical path for OR-PAM (light delivery) and OCT (light delivery/detection), and a 40-MHz unfocused ultrasound transducer for OR-PAM (photoacoustic detection) and US (ultrasound transmission/receiving) with an overall diameter of 2 mm. Combining OR-PAM, OCT, and US would provide complementary information including optical absorption (OR-PAM), optical back-scattering (OCT), and deep tissue structures (US) about biological tissue. Based on an integrated ...

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    7. Swept-source common-path optical coherence tomography with a MEMS endoscopic imaging probe

      Swept-source common-path optical coherence tomography with a MEMS endoscopic imaging probe

      A MEMS-based common-path endoscopic imaging probe for 3D swept-source optical coherence tomography (SSOCT) has been developed. The common path is achieved by setting the reference plane at the rear surface of the GRIN lens inside the probe. MEMS devices have the advantages of low cost, small size and fast speed, which are suitable for miniaturizing endoscopic probes. The aperture size of the two-axis MEMS mirror employed in this endoscopic probe is 1 mm by 1 mm and the footprint of the MEMS chip is 1.55 mm by 1.7 mm. The MEMS mirror achieves large two dimensional optical scan ...

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    8. Feature Of The Week 9/29/13: Utilizing MEMs 2-Axis Mirror Scanners in an Endoscopic OCT Probe

      Feature Of The Week 9/29/13: Utilizing MEMs 2-Axis Mirror Scanners in an Endoscopic OCT Probe

      MEMs scanning technology offers many promising features such as low-cost and small size and seem likely to impact commercial OCT probes in the not too distant future. Recently researchers from the University of Shanghai for Science and Technology, WiO Technology Company, Nanjing Medical University, and University of Florida demonstrated an endoscopic OCT probe based on a 2-axis MEMS mirror. Below is a summary of their recent work. A microelectromechanical system (MEMS) mirror based endoscopic swept-source optical coherence tomography (SS-OCT) system that can perform three-dimensional (3-D) imaging at high speed is reported. The key component enabling 3-D endoscopic imaging is a ...

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    9. Probe alignment and design issues of microelectromechanical system based optical coherence tomography endoscopic imaging

      Probe alignment and design issues of microelectromechanical system based optical coherence tomography endoscopic imaging

      Endoscopic optical coherence tomography (OCT) imaging has been demonstrated using microelectromechanical system (MEMS) technology by several research groups. The focus of this work is to study how the OCT imaging performance is affected by the radius of curvature of MEMS mirrors as well as the optical alignment accuracy inside small imaging probes. The goal of this study is to provide guidance for assembly tolerance and design optimization of OCT endoscopic probes. Gaussian beam propagation is used for theoretical analysis which is confirmed by optical simulation and verified experimentally with a time-domain OCT system as well. It has been found that ...

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    10. Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror

      Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror

      A microelectromechanical system (MEMS) mirror based endoscopic swept-source optical coherence tomography (SS-OCT) system that can perform three-dimensional (3-D) imaging at high speed is reported. The key component enabling 3-D endoscopic imaging is a two-axis MEMS scanning mirror which has a 0.8 × 0.8     mm 2 mirror plate and a 1.6 × 1.4     mm 2 device footprint. The diameter of the endoscopic probe is only 3.5 mm. The imaging rate of the SS-OCT system is 50     frames / s . OCT images of both human suspicious oral leukoplakia tissue and normal buccal mucosa were taken in vivo and compared. The ...

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    11. Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivomicrocirculation study

      Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivomicrocirculation study

      Photoacoustic microscopy (PAM) is sensitive to optical absorption, while optical coherence tomography (OCT) is based on optical backscattering. Combining PAM and OCT can provide complementary information about biological tissue. Here we present a combined optical-resolution PAM (ORPAM) and OCT system that is integrated through a miniature probe with an overall diameter of 2.3 mm, suitable for insertion through a standard endoscopic or laparoscopic port during minimally invasive surgery or endoscopic exam. The hybrid probe consists of a common optical path for OCT (light delivery/detection) and ORPAM (light excitation) and a 10 MHz unfocused ultrasound transducer for photoacoustic detection ...

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    1-11 of 11
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    1. (10 articles) University of Florida
    2. (9 articles) Huikai K. Xie
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    Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivomicrocirculation study Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror Probe alignment and design issues of microelectromechanical system based optical coherence tomography endoscopic imaging Feature Of The Week 9/29/13: Utilizing MEMs 2-Axis Mirror Scanners in an Endoscopic OCT Probe Swept-source common-path optical coherence tomography with a MEMS endoscopic imaging probe Miniature probe integrating optical-resolution photoacoustic microscopy, optical coherence tomography, and ultrasound imaging: proof-of-concept Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe Planar and Integrated MEMS Micromirrors Based Endoscopic Optical Coherence Tomography (Thesis) Miniature multimodal endoscopic probe based on double-clad fiber Circumferential-scanning endoscopic optical coherence tomography probe based on a circular array of six 2-axis MEMS mirrors Comparative study between intravitreal ranibizumab and triamcinolone treatment of diabetic macular edema as regard to optical coherence tomography changes and visual acuity What’s New in Optical Coherence Tomography Angiography for Glaucoma (Book Chapter)