1. Articles from Sebastian Goebel

    1-4 of 4
    1. Multiwavelength phase unwrapping and aberration correction using depth filtered digital holography

      Multiwavelength phase unwrapping and aberration correction using depth filtered digital holography

      In this Letter, we present a new approach to processing data from a standard spectral domain optical coherence tomography (OCT) system using depth filtered digital holography (DFDH). Intensity-based OCT processing has an axial resolution of the order of a few micrometers. When the phase information is used to obtain optical path length differences, subwavelength accuracy can be achieved, but this limits the resolvable step heights to half of the wavelength of the system. Thus there is a metrology gap between phase- and intensity-based methods. Our concept addresses this metrology gap by combining DFHD with multiwavelength phase unwrapping. Additionally, the measurements ...

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    2. Comparison of different metrics for analysis and visualization in spectroscopic optical coherence tomography

      Comparison of different metrics for analysis and visualization in spectroscopic optical coherence tomography

      Spectroscopic Optical Coherence Tomography (S-OCT) extracts depth resolved spectra that are inherently available from OCT signals. The back scattered spectra contain useful functional information regarding the sample, since the light is altered by wavelength dependent absorption and scattering caused by chromophores and structures of the sample. Two aspects dominate the performance of S-OCT: (1) the spectral analysis processing method used to obtain the spatially-resolved spectroscopic information and (2) the metrics used to visualize and interpret relevant sample features. In this work, we focus on the second aspect, where we will compare established and novel metrics for S-OCT. These concepts include ...

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    3. Spectroscopic optical coherence tomography with graphics processing unit based analysis of three dimensional data sets

      Spectroscopic optical coherence tomography with graphics processing unit based analysis of three dimensional data sets

      Spectroscopic optical coherence tomography (OCT) is an extension of the standard backscattering intensity analysis of OCT. It enables depth resolved monitoring of molecular and structural differences of tissue. One drawback of most methods to calculate the spectroscopic data is the long processing time. Also systematic and stochastic errors make the interpretation of the results challenging. Our approach combines modern signal processing tools with powerful graphics processing unit (GPU) programming. The processing speed for the spectroscopic analysis is nearly 3 mega voxel per second. This allows us to analyze multiple B-Scans in a few seconds and to display the results as ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) Martin R. Hofmann
    2. (4 articles) Volker Jaedicke
    3. (4 articles) Nils C. Gerhardt
    4. (1 articles) Duke University
    5. (1 articles) Dresden University of Technology
    6. (1 articles) Francisco E. Robles
    7. (1 articles) Kawasaki Medical School
    8. (1 articles) Tianjin University
    9. (1 articles) Harbin Medical University
    10. (1 articles) Hector M. Garcia-Garcia
    11. (1 articles) Bo Yu
    12. (1 articles) Ron Waksman
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