1. Articles from Konstantina M. Stankovic

    1-4 of 4
    1. Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

      Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

      Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea's inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (μOCT) imaging system to enable micron-scale imaging of the inner ear's ...

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    2. Visualizing cellular markers of sensorineural hearing loss in the murine cochlea using micro-optical coherence tomography

      Visualizing cellular markers of sensorineural hearing loss in the murine cochlea using micro-optical coherence tomography

      Although sensorineural hearing loss (SNHL) affects 600 million people globally and its prevalence is increasing, therapies remain limited. Advances in therapy development for SNHL are slow because we do not possess a method for visualizing the cochlea’s interior in living humans and relating visualized pathology to a patient’s hearing ability. To this end, we are investigating the ability of micro-optical coherence tomography (µOCT), a low-coherence interferometric imaging technique that requires no contrast agent and improves upon standard OCT in resolution and depth of focus, to visualize the micron-sized cellular structures in the cochlea. We recently demonstrated µOCT’s ...

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    3. Micro-optical coherence tomography of the mammalian cochlea

      Micro-optical coherence tomography of the mammalian cochlea

      The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded location within the temporal bone. As a result, little is known about the relationship between an individual’s cochlear pathology and hearing function, and otologists must rely on physiological testing and imaging methods that offer limited resolution to obtain information about the inner ear prior to performing surgery. Micro-optical coherence tomography (μOCT) is a non-invasive, low-coherence interferometric imaging technique capable of resolving cellular-level anatomic structures. To determine whether μOCT is capable of resolving mammalian intracochlear anatomy, fixed guinea pig ...

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    4. Quantitative polarized light microscopy of unstained mammalian cochlear sections

      Quantitative polarized light microscopy of unstained mammalian cochlear sections

      Hearing loss is the most common sensory deficit in the world, and most frequently it originates in the inner ear. Yet, the inner ear has been difficult to access for diagnosis because of its small size, delicate nature, complex three-dimensional anatomy, and encasement in the densest bone in the body. Evolving optical methods are promising to afford cellular diagnosis of pathologic changes in the inner ear. To appropriately interpret results from these emerging technologies, it is important to characterize optical properties of cochlear tissues. Here, we focus on that characterization using quantitative polarized light microscopy (qPLM) applied to unstained cochlear ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) Harvard University
    2. (3 articles) Massachusetts General Hospital
    3. (2 articles) Massachusetts Eye and Ear Infirmary
    4. (1 articles) Stanford University
    5. (1 articles) Massachusetts Institute of Technology
    6. (1 articles) Sun Yat-Sen University
    7. (1 articles) Vanderbilt University
    8. (1 articles) Yale University
    9. (1 articles) Cleveland Clinic
    10. (1 articles) Northwestern University
    11. (1 articles) University of North Carolina
    12. (1 articles) Carl Zeiss Meditec
    13. (1 articles) Alcon
    14. (1 articles) Audioptics Medical
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    Quantitative polarized light microscopy of unstained mammalian cochlear sections Micro-optical coherence tomography of the mammalian cochlea Visualizing cellular markers of sensorineural hearing loss in the murine cochlea using micro-optical coherence tomography Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter Optical Coherence Tomography of the Middle Ear Using Ossiview Role of Optical Coherence Tomography Angiography Imaging in Patients with Diabetes Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes Investigation of Micro-motion Kinematics of Continuum Robots for Volumetric OCT and OCT-guided Visual Servoing Association of Myopia With Microvascular Alterations in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study Accuracy of Total Corneal Power Calculation for Multifocal Toric Intraocular Lens Implantation: Swept-Source OCT-Based Biometer vs Scheimpflug Tomographer Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy New Method for Reducing Artifactual Flow Deficits Caused by Compensation Techniques in the Choriocapillaris with Optical Coherence Tomography Angiography