1. Articles from Careen Y. Lowder

    1-11 of 11
    1. Ultra-widefield Fluorescein Angiography and Optical Coherence Tomography Findings in Tubulointerstitial Nephritis and Uveitis Syndrome

      Ultra-widefield Fluorescein Angiography and Optical Coherence Tomography Findings in Tubulointerstitial Nephritis and Uveitis Syndrome

      Purpose To report the spectrum of posterior segment findings in tubulointerstitial nephritis and uveitis syndrome (TINU) and discuss the abnormalities that can be seen on imaging. Design Retrospective, consecutive case series. Participants Patients with TINU and posterior segment manifestations on exam or imaging. Methods Patients with elevated urine beta-2 microglobulin (Uβ2M) and a diagnosis of TINU were included if they were evaluated at the Cole Eye Institute and did not have alternative etiologies for uveitis. Electronic medical records were reviewed for abnormal findings on ultra-widefield fluorescein angiography (UWFFA) and optical coherence tomography (OCT). Main Outcome Measures Presence of peripheral ...

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    2. Imaging of Iris Lesions With High-Speed Optical Coherence Tomography

      Imaging of Iris Lesions With High-Speed Optical Coherence Tomography

      n BACKGROUND AND OBJECTIVES:To image and measure iris tumors with optical coherence tomography (OCT). n PATIENTS AND METHODS:High-speed(2,000– 4,000 axial-scan/sec and 4–16 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma. OCT images were compared with slit-lamp photography and ultrasound biomicroscopy. n RESULTS: OCT at 1.3-micron wavelength could penetrate the full thickness of the iris lesions and allow three-dimensional measurement of lesion ...

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    3. The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases

      The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases

      Since its introduction in the early 1990s, optical coherence tomography (OCT) has evolved in resolution and technological advances, and in recent years its initial application of assessing the morphology of a tissue has been implemented by the study of its functional blood flow, through optical coherence tomography angiography (OCTA). This novel technique details capillary networks by comparing the amount of light returned from static and moving targets without the need for intravenous dye administration. While this imaging modality has been used for various ocular conditions, the application OCTA to uveitis conditions remains sparse. This review aims to establish the basis ...

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    4. EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MULTIPLE EVANESCENT WHITE DOT SYNDROME: New Insights Into Pathogenesis

      EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MULTIPLE EVANESCENT WHITE DOT SYNDROME: New Insights Into Pathogenesis

      Purpose: To localize the various levels of abnormalities in multiple evanescent white dot syndrome by comparing "en face" optical coherence tomography (OCT) and OCT angiography with various conventional imaging modalities. Methods: In this retrospective case series, multimodal imaging was performed in 9 retinal centers on 36 patients with multiple evanescent white dot syndrome and included widefield fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography, and B-scan and "en face" C-scan enhanced depth imaging and spectral domain OCT. Optical coherence tomography angiography was also performed at the level of the superficial and deep retinal capillary plexus and choroid. Results ...

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    5. Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis

      Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis

      Purpose To describe the findings seen on optical coherence tomography angiography (OCTA) in patients with punctate inner choroidopathy (PIC) and multifocal choroiditis and panuveitis (MCP) complicated by choroidal neovascular membranes. Methods This was an Institutional Review Board-approved prospective, descriptive case series. 12 patients with PIC and MCP complicated by choroidal neovascularisation (CNV) were included. Each patient underwent slit-lamp examination by a uveitis specialist followed by conventional spectral domain OCT imaging of the macula. OCTA images of the macula were then obtained. Results 12 patients were enrolled in the study, out of which 9 patients were followed longitudinally. CNV was identified ...

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    6. A Focal Chorioretinal Bartonella Lesion Analyzed by Optical Coherence Tomography Angiography

      A Focal Chorioretinal Bartonella Lesion Analyzed by Optical Coherence Tomography Angiography

      Neovascularization may be associated with cat-scratch neuroretinitis in the absence of retinal vascular occlusion. Bartonella organisms establish an intimate relationship with the vascular endothelium, causing angioproliferative lesions, which might represent a dedicated pathogenic strategy for expanding the bacterial host cell habitat. In the eye, pathological angiogenesis caused by Bartonella has been described as peripapillary or macular choroidal neovascularization, but the presence of neovascularization within foci of chorioretinitis has never before been reported. The authors present a case of Bartonella chorioretinitis in which optical coherence tomography angiography, by detecting erythrocyte motion, was able to identify neovessels inside the infectious focus.

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    7. New appraisals of Kyrieleis plaques: a multimodal imaging study

      New appraisals of Kyrieleis plaques: a multimodal imaging study

      Purpose Kyrieleis retinal periarteritis reflects the severe intraocular inflammation experienced by the eye. Its aetiology has not been well established, since only nine cases have been reported and there is no pathological study available in the literature. We determine the pathogenesis of Kyrieleis periarteritis based on interpretation of multimodal imaging findings. Methods Charts of patients with Kyrieleis arteritis seen between 2006 and 2014 were retrieved from eight uveitis referral centres throughout the world. Follow-up ranged from 5 to 12 months. Results Twenty-five eyes with Kyrieleis arteritis from 25 patients were included in the study. Nineteen patients (72%) were male and ...

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    8. OCT Angiography Identification of Choroidal Neovascularization Secondary to Acute Zonal Occult Outer Retinopathy

      OCT Angiography Identification of Choroidal Neovascularization Secondary to Acute Zonal Occult Outer Retinopathy

      A 74-year-old female with acute zonal occult outer retinopathy presented with a new lesion suspicious for choroidal neovascularization (CNV) in her right eye. Optical coherence tomography angiography (OCTA) confirmed the presence of CNV. OCTA is a new imaging technique that may help guide diagnosis and management of choroidal neovascular membranes in uveitic diseases.

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    9. Anterior segment spectral domain optical coherence tomography imaging of patients with anterior scleritis

      Anterior segment spectral domain optical coherence tomography imaging of patients with anterior scleritis

      The purpose of the study was to describe the findings seen on anterior segment spectral domain optical coherence tomography (SD-OCT) in patients with anterior scleritis and determine the feasibility of using SD-OCT to image and grade the degree of scleral inflammation and monitor response to treatment. All patients underwent slit lamp examination by a uveitis specialist, and the degree of scleral inflammation was recorded. Spectral domain OCT imaging was then performed of the conjunctiva and scleral tissue using a standardized acquisition protocol. The scans were graded and compared to clinical findings. Twenty-eight patients with anterior scleritis and ten patients without ...

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    10. Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography

      Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography

      Purpose This study was designed to determine the feasibility of anterior segment optical coherence tomography (AS-OCT) to objectively image and quantify the degree of AC inflammation. Design Prospective evaluation of a diagnostic test. Participants Patients with anterior segment involving uveitis. Methods Observational case series of patients with uveitis. Single-line and 3-dimensional (3D) volume AS-OCT scans were manually graded to evaluate for the presence or absence of cells in the AC. Clinical grading scores were correlated to the number of cells seen in each line scan. An automated algorithm was developed to measure the number of cells seen in the 3D ...

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    11. EARLY TREATMENT RESPONSE OF FLUOCINOLONE (RETISERT) IMPLANTATION IN PATIENTS WITH UVEITIC MACULAR EDEMA: An Optical Coherence Tomography Study

      EARLY TREATMENT RESPONSE OF FLUOCINOLONE (RETISERT) IMPLANTATION IN PATIENTS WITH UVEITIC MACULAR EDEMA: An Optical Coherence Tomography Study

      Purpose: To analyze the early spectral domain optical coherence tomography changes after fluocinolone implantation in eyes with baseline uveitic macular edema. Methods: Patients with uveitic macular edema and who received fluocinolone implantations by 2 surgeons (R.P.S. and J.E.S.) at the Cole Eye Institute (Cleveland Clinic, Cleveland, OH) from September 2009 to July 2010 were eligible for this study. Best-corrected visual acuity, intraocular pressure, central subfield thickness, cube volume, cube average thickness, and cystoid macular edema grade were recorded before implantation and in the early postoperative period (median: 3 months postimplantation). Changes in these variables were analyzed ...

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      Mentions: Cleveland Clinic
    1-11 of 11
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    EARLY TREATMENT RESPONSE OF FLUOCINOLONE (RETISERT) IMPLANTATION IN PATIENTS WITH UVEITIC MACULAR EDEMA: An Optical Coherence Tomography Study Automated Analysis of Anterior Chamber Inflammation by Spectral-Domain Optical Coherence Tomography Anterior segment spectral domain optical coherence tomography imaging of patients with anterior scleritis OCT Angiography Identification of Choroidal Neovascularization Secondary to Acute Zonal Occult Outer Retinopathy New appraisals of Kyrieleis plaques: a multimodal imaging study A Focal Chorioretinal Bartonella Lesion Analyzed by Optical Coherence Tomography Angiography Choroidal neovascularisation on optical coherence tomography angiography in punctate inner choroidopathy and multifocal choroiditis EN FACE OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF MULTIPLE EVANESCENT WHITE DOT SYNDROME: New Insights Into Pathogenesis The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases Imaging of Iris Lesions With High-Speed Optical Coherence Tomography In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances The Association of Optical Coherence Tomography Results With Neuroimaging Signs and Some Clinical Parameters in Idiopathic Intracranial Hypertension