1. Articles from Matteo Ghione

    1-11 of 11
    1. Absorb vs. DESolve: an optical coherence tomography comparison of acute mechanical performances

      Absorb vs. DESolve: an optical coherence tomography comparison of acute mechanical performances

      Aims: The aim of the study was to compare retrospectively the acute mechanical performance of the Absorb vs. DESolve scaffolds in terms of appropriate deployment with OCT. Methods and results: Final post-deployment OCT pullbacks of consecutive patients treated with either Absorb or DESolve were reviewed. The following parameters were calculated and compared: mean and minimal lumen area (MLA), residual in-scaffold area stenosis (RAS), incomplete strut apposition (ISA), tissue prolapse area, eccentricity index, asymmetry index, strut fracture and edge dissection. A total of 72 patients were included. The Absorb group consisted of 35 patients treated with 63 Absorb scaffolds and was ...

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    2. ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      Objectives The aim of this study was to compare the acute performance of the PLLA ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) with second-generation metal drug-eluting stents (DES) in complex coronary artery lesions. Background Thick polymer-based BVS have different mechanical properties than thin second-generation DES. Data on the acute performance of BVS are limited to simple coronary lesions treated in trials with strict inclusion criteria. Methods Fifty complex coronary lesions (all type American College of Cardiology/American Heart Association B2-C) treated with a BVS undergoing a final optical coherence tomography (OCT) examination were compared with an equal ...

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    3. Intracoronary optical coherence tomography: a review of clinical applications

      Intracoronary optical coherence tomography: a review of clinical applications

      Optical coherence tomography (OCT) is a light-based technology that provides very high spatial resolution images. OCT has been initially employed as a research tool to investigate plaque morphology and stent strut coverage. The introduction of frequency domain OCT allowing fast image acquisition during a prolonged contrast injection via the guiding catheter has made OCT applicable for guidance of coronary interventions. In this manuscript, the various applications of OCT are reviewed, from assessment of plaque vulnerability and severity to characteristics of unstable lesions and thrombus burden to stent optimization and evaluation of late results.

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    4. Optical coherence tomography characteristics of in-stent restenosis are different between first and second generation drug eluting stents ☆

      Optical coherence tomography characteristics of in-stent restenosis are different between first and second generation drug eluting stents ☆

      Aims Characterization of neointimal tissue is essential to understand the pathophysiology of in-stent restenosis (ISR) after drug eluting stent (DES) implantation. Using optical coherence tomography (OCT), we compared the morphologic characteristics of ISR between first and second generation DES. Methods and Results OCT was performed in 66 DES-ISR, defined as > 50% angiographic diameter stenosis within the stented segment. Patients with ISR of first generation sirolimus-eluting stents (SES), paclitaxel eluting stents (PES) and second generation zotarolimus-eluting stents (ZES), everolimus-eluting stents (EES) and biolimus-eluting stents (BES) were enrolled. Quantitative and qualitative ISR tissue analysis was performed at 1-mm intervals along the entire ...

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    5. Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition

      Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition

      BACKGROUND: Lack of re-endothelialization and neointimal coverage on stent struts has been put forward as the main underlying mechanism leading to late stent thrombosis. Incomplete stent apposition (ISA) has been observed frequently in patients with very late stent thrombosis after drug eluting stent implantation, suggesting a role of ISA in the pathogenesis of this adverse event. The aim of this study was to evaluate the impact of different degrees of ISA severity on abnormal shear rate and healing response with coverage, because of its potential implications for stent optimization in clinical practice. METHODS AND RESULTS: We characterized flow profile and ...

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    6. Intracoronary Optical Coherence Tomography: Experience and Indications for Clinical Use

      Intracoronary Optical Coherence Tomography: Experience and Indications for Clinical Use

      Optical coherence tomography (OCT) is a light based technology that provides very high spatial resolution images. OCT has been initially employed as a research tool to investigate plaque morphology and stent strut coverage. The introduction of frequency domain OCT, allowing fast image acquisition during a prolonged contrast injection via the guiding catheter, has made OCT applicable for guidance of coronary interventions. In this manuscript the various applications of OCT are reviewed, from assessment of plaque vulnerability and severity to characteristics of unstable lesions and thrombus burden to stent optimization and evaluation of late results

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    7. Bioabsorbable scaffold optimization in provisional stenting: insight from optical coherence tomography

      Bioabsorbable scaffold optimization in provisional stenting: insight from optical coherence tomography

      Since the emergence of biabsorbable vascular scaffolds (BVS), treatment of bifurcation lesions with these devices has remained a source of question. Although SB dilatation has been previously performed with BVS, it is not yet clear how dilatation across BVS strut may impact scaffold structure. A 74-year-old lady with hypercholesterolaemia and …

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    8. Endovascular Imaging and 3-Dimensional Reconstruction of Spontaneous Coronary Artery Dissection

      Endovascular Imaging and 3-Dimensional Reconstruction of Spontaneous Coronary Artery Dissection

      A 57-year-old woman without coronary risk factors presented with non–ST-segment elevation myocardial infarction. Angiography revealed a normal anterior descending artery with lumen irregularities in the middle part (A, B, C) . Intravascular ultrasound (IVUS) (D, E, F) disclosed an intramural hematoma along the middle segment of the artery. Optical coherence tomography (OCT), resolution 15 μm, showed a proximal entry tear (G, H, arrow) , a large intramural hematoma (*) that compress the true lumen (TL) and a re-entry tear in the distal part (J) . The OCT 3-dimensional (3-D) reconstruction clearly visualize the spiral development of the dissection and the severe compression of ...

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    9. Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases

      Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases

      Purpose To allow an accurate diagnosis of coronary artery diseases by enhancing optical coherence tomography (OCT) images of atheromatous plaques using a novel automated attenuation compensation technique. Background One of the major drawbacks of coronary OCT imaging is the rapid attenuation of the OCT signal, limiting penetration in tissue to only few millimetres. Visualisation of deeper anatomy is however critical for accurate assessment of plaque burden in-vivo. Methods A compensation algorithm, previously developed to correct for light attenuation in soft tissues and to enhance contrast in ophthalmic OCT images, was applied to intracoronary plaque imaging using spectral-domain OCT. Results Application ...

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    10. Sealing old plaques, seeding new plaques

      Sealing old plaques, seeding new plaques

      In stent restenosis (ISR) is a heterogeneous phenomenon. The classical paradigm is neointimal proliferation in response to vessel wall injury often in combination with incomplete stent expansion. Drug-eluting stents (DES) have been designed to reduce or eliminate hyperplasia and in fact dramatically reduced restenosis and target lesion revascularization (TLR). The drawback of DES has been an increase in late and very late stent thrombosis, a potentially life-threatening complication considered a consequence of delayed and incomplete strut endothelialization. The article of Habara et al . 1 challenges this concept by analysing in-stent restenosis with optical coherence tomography (OCT) in the first generation ...

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    1-11 of 11
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    1. (10 articles) Carlo Di Mario
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    Sealing old plaques, seeding new plaques Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases Endovascular Imaging and 3-Dimensional Reconstruction of Spontaneous Coronary Artery Dissection Bioabsorbable scaffold optimization in provisional stenting: insight from optical coherence tomography Intracoronary Optical Coherence Tomography: Experience and Indications for Clinical Use Early coverage of Bioabsorbable Scaffold after STEMI analysed by 2D and 3D optical coherence tomography Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition Optical coherence tomography characteristics of in-stent restenosis are different between first and second generation drug eluting stents ☆ ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance Absorb vs. DESolve: an optical coherence tomography comparison of acute mechanical performances Optical coherence tomography angiography (OCTA) findings in Serpiginous Choroiditis Changes in retinal layer thickness with maturation in the dog: an in vivo spectral domain - optical coherence tomography imaging study