1. Articles from Hiroyuki Hao

    1-9 of 9
    1. Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Background Optical coherence tomography (OCT) is one of the tools trying to distinguish neoatherosclerosis from other neointimal tissue but its role has to be still validated. This study evaluated the diagnostic accuracy of OCT for characterization of lipid-atherosclerotic neointima following drug-eluting stent (DES) implantation. Methods Twelve stented coronary arteries from the 7 autopsy hearts were imaged by OCT. These OCT images were compared with histology. By OCT, the morphological appearances of neointima were classified into three patterns: homogeneous pattern, heterogeneous pattern with visible strut, or heterogeneous pattern with invisible strut. Results Of 21 histological cross-sections, 6 were categorized as homogeneous ...

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    2. Tissue Characterization of In-Stent Neointima Using Optical Coherence Tomography in the Late Phase After Bare-Metal Stent Implantation – An Ex Vivo Validation Study –

      Tissue Characterization of In-Stent Neointima Using Optical Coherence Tomography in the Late Phase After Bare-Metal Stent Implantation – An Ex Vivo Validation Study –

      Background: We performed an ex vivo study to investigate optical coherence tomography (OCT) imaging for differentiating several types of neointimal tissue during the later phases after bare-metal stent (BMS) implantation as compared with histologic results. Methods and Results: OCT imaging was performed in 6 autopsy hearts for 10 BMS with implant duration >4 years. OCT qualitative neointimal tissue characterization was based on tissue structure and classified as homogeneous pattern, heterogeneous pattern with visible struts, or heterogeneous pattern with invisible struts. Corresponding histological analyses of each 2-mm cross-section of the entire BMS were performed. Of 81 cross-sections, histological analysis revealed that ...

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      Mentions: Abbot Kenichi Fujii
    3. Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings

      Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings

      An 83-year-old woman was referred to our hospital due to diverticular bleeding of the colon. She had a history of everolimus-eluting stent implantation in the left anterior descending artery (31 months before) and the right coronary artery (20 and 31 months before) because of stable angina. She was prescribed aspirin 100 mg/day and clopidogrel 75 mg/day, followed by single antiplatelet therapy by aspirin during the last 8 months. Aspirin was discontinued for the endoscopic therapy at her admission. Complete blood count showed hemoglobin of 17.5 g/dl and hematocrit of 55.2%, from which polycythemia vera (PV ...

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      Mentions: Abbot Kenichi Fujii
    4. Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Objectives This study sought to assess the accuracy of optical coherence tomography (OCT), gray-scale intravascular ultrasound (IVUS), and their combination for detecting thin-cap fibroatheromas (TCFA). Background The extent to which the imaging characteristics of OCT and IVUS correlate with histologically defined TCFA is unknown. Methods IVUS and OCT examinations identified focal plaques in 165 coronary arteries from 60 autopsy hearts. A total of 685 pairs of images of OCT and IVUS were compared with histology. By OCT, a TCFA was defined as a signal-poor region with diffuse borders and cap thickness <65 μm. By IVUS, a TCFA was defined by ...

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    5. Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy

      Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy

      An 89-year-old woman who suffered a stroke and congestive heart failure was admitted to our hospital. She died of heart failure and autopsy was performed. Coronary arteries were removed from the heart and used for ex vivo imaging of intravascular ultrasound ([IVUS]; Atlantis, Boston Scientific Corporation, Natick, Massachusetts), optical coherence tomography (LightLab imaging Inc., Westford, Massachusetts), and coronary angioscopy (FiberTech, Tokyo, Japan) within 6 h after death before fixation with 10% buffered formalin. IVUS illustrated a convex lesion with superficial hyperechoic signal accompanied by acoustic shadowing at the left anterior descending artery (Figure 1 , arrows). Optical coherence tomography demonstrated an ...

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    6. Can Optical Coherence Tomography Findings Be Used as Surrogates for Vessel Healing After Drug-Eluting Stent Implantation?

      Can Optical Coherence Tomography Findings Be Used as Surrogates for Vessel Healing After Drug-Eluting Stent Implantation?

      Drug-eluting stents (DES) inhibit neointimal proliferation and reduce the rates of subsequent target lesion revascularization as compared with bare-metal stents in randomized clinical trials.1,2 However, too much inhibition of neointimal hyperplasia might cause delayed vascular healing with incomplete endothelialization, which has been associated with an increase risk of stent thrombosis.3,4 Therefore, accurate assessment of the neointimal coverage in DES may be critical in prognosticating their safety. Optical coherence tomography (OCT) uses near-infrared light and generate crosssectional images by measuring the echo time delay and intensity of light that is reflected or back-scattered from the tissue. The ...

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      Mentions: Kenichi Fujii
    7. Intracoronary Imaging for Detecting Vulnerable Plaque

      Intracoronary Imaging for Detecting Vulnerable Plaque

      It is now generally recognized that acute coronary syndromes most commonly result from disruption of thin-cap fibroatheroma (TCFA), which is characterized by a large necrotic core with an overlying thin-fibrous cap measuring <65μm. Recent advances in intracoronary imaging modalities have significantly improved the ability to detect TCFA in vivo. Intravascular ultrasound (IVUS) is perhaps the most promising modality that has been used more than 15 years to evaluate atherosclerotic plaque. IVUS has revealed a lot of the clinical evidence regarding vulnerable plaque detection in live humans. Recently, by analyzing the IVUS acoustic signal before demodulation and scan conversion, IVUS ...

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    1-9 of 9
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  2. Topics in the News

    1. (7 articles) Kenichi Fujii
    2. (3 articles) Abbot
    3. (2 articles) Mitsumasa Ohyanagi
    4. (2 articles) Kyungpook National University
    5. (2 articles) University of Washington
    6. (2 articles) Jeehyun Kim
    7. (2 articles) Ruchire Eranga Wijesinghe
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    Intracoronary Imaging for Detecting Vulnerable Plaque In-Stent Thin-Cap Fibroatheroma After Drug-Eluting Stent Implantation: Ex-Vivo Evaluation of Optical Coherence Tomography and Intracoronary Angioscopy Can Optical Coherence Tomography Findings Be Used as Surrogates for Vessel Healing After Drug-Eluting Stent Implantation? Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy Reply: Calcified Nodule Mimicking Red Thrombus on Optical Coherence Tomography Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings Tissue Characterization of In-Stent Neointima Using Optical Coherence Tomography in the Late Phase After Bare-Metal Stent Implantation – An Ex Vivo Validation Study – Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations Vision-Inspection-Synchronized Dual Optical Coherence Tomography for High-Resolution Real-Time Multidimensional Defect Tracking in Optical Thin Film Industry Relative retinal flow velocity detection using optical coherence tomography angiography imaging