1. Articles from Vedran Kajic

    1-11 of 11
    1. Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography

      Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography

      Objectives To examine the feasibility of automatically segmented choroidal vessels in three-dimensional (3D) 1060-nmOCT by testing repeatability in healthy and AMD eyes and by mapping Haller's and Sattler's layer thickness in healthy eyes Methods Fifty-five eyes (from 45 healthy subjects and 10 with non-neovascular age-related macular degeneration (AMD) subjects) were imaged by 3D-1060-nmOCT over a 36°x36° field of view. Haller's and Sattler's layer were automatically segmented, mapped and averaged across the Early Treatment Diabetic Retinopathy Study grid. For ten AMD eyes and ten healthy eyes, imaging was repeated within the same session and on another ...

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    2. Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Optical coherence tomography (OCT) has revolutionises the diagnosis of retinal disease based on the detection of microscopic rather than subcellular changes in retinal anatomy. However, currently the technique is limited to the detection of microscopic rather than subcellular changes in retinal anatomy. However, coherence based imaging is extremely sensitive to both changes in optical contrast and cellular events at the micrometer scale, and can generate subtle changes in the spectral content of the OCT image. Here we test the hypothesis that OCT image speckle (image texture) contains information regarding otherwise unresolvable features such as organelle changes arising in the early ...

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    3. Choroidal Thinning in Diabetes Type 1 Detected by 3-Dimensional 1060 nm Optical Coherence Tomography

      Choroidal Thinning in Diabetes Type 1 Detected by 3-Dimensional 1060 nm Optical Coherence Tomography
      Purpose. To map choroidal (ChT) and retinal thickness (RT) in patients with diabetes type 1 with and without maculopathy and retinopathy in order to compare them with healthy subjects using high speed 3-dimensional (3D) 1060 nm optical coherence tomography (OCT). Methods. Thirty-three eyes from 33 diabetes type 1 subjects (23–57 years, 15 male) divided into groups of without pathology (NDR) and with pathology (DR; including microaneurysms, exudates, clinically significant macular-oedema and proliferative retinopathy) were compared with 20 healthy axial eye length and age-matched subjects (24–57 years, 9 male), imaged by high speed (60.000 A-scans/s) 3D 1060 ...
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    4. Automated choroidal segmentation of 1060 nm OCT in healthy and pathologic eyes using a statistical model

      Automated choroidal segmentation of 1060 nm OCT in healthy and pathologic eyes using a statistical model
      A two stage statistical model based on texture and shape for fully automatic choroidal segmentation of normal and pathologic eyes obtained by a 1060 nm optical coherence tomography (OCT) system is developed. A novel dynamic programming approach is implemented to determine location of the retinal pigment epithelium/ Bruch’s membrane /choriocapillaris (RBC) boundary. The choroid–sclera interface (CSI) is segmented using a statistical model. The algorithm is robust even in presence of speckle noise, low signal (thick choroid), retinal pigment epithelium (RPE) detachments and atrophy, drusen, shadowing and other artifacts. Evaluation against a set of 871 manually segmented cross-sectional scans ...
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    5. Mapping Choroidal and Retinal Thickness Variation in Type 2 Diabetes using Three-Dimensional 1060-nm Optical Coherence Tomography

      Mapping Choroidal and Retinal Thickness Variation in Type 2 Diabetes using Three-Dimensional 1060-nm Optical Coherence Tomography
      Purpose. To map choroidal (ChT) and retinal thickness (RT) in healthy subjects and patients with diabetes with and without maculopathy using three dimensional 1060-nm optical coherence tomography (3D-1060nm-OCT). Methods. Sixty-three eyes from 42 diabetic subjects (41–82 years of age; 11 females) grouped according to a custom scheme using Early Treatment Diabetic Retinopathy Study definitions for pathology within 1 disc-diameter of fovea (without pathology [NDR], microaneurysms [M1], exudates [M2], clinically significant macular edema [CSME]) and 16 eyes from 16 healthy age matched subjects (38–79 years of age; 11 females) were imaged by 3D-1060nm-OCT performed over a 36° × 36° field ...
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    6. Artefact reduction for cell migration visualization using spectral domain optical coherence tomography

      Artefact reduction for cell migration visualization using spectral domain optical coherence tomography
      Visualization of cell migration during chemotaxis using spectral domain optical coherence tomography (OCT) requires non-standard processing techniques. Stripe artefacts and camera noise floor present in OCT data prevent detailed computer-assisted reconstruction and quantification of cell locomotion. Furthermore, imaging artefacts lead to unreliable results in automated texture based cell analysis. Here we characterize three pronounced artefacts that become visible when imaging sample structures with high dynamic range, e.g. cultured cells: (i) time-varying fixed-pattern noise; (ii) stripe artefacts generated by background estimation using tomogram averaging; (iii) image modulations due to spectral shaping. We evaluate techniques to minimize the above mentioned artefacts ...
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    7. Three-Dimensional 1060-nm OCT: Choroidal Thickness Maps in Normal Subjects and Improved Posterior Segment Visualization in Cataract Patients

      Three-Dimensional 1060-nm OCT: Choroidal Thickness Maps in Normal Subjects and Improved Posterior Segment Visualization in Cataract Patients
      Purpose. To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. Methods. Axial lengths (ALs) and 45° fundus photographs were acquired from 64 eyes (34 healthy subjects, 19 to 80 years, ametropia +3 to –10 D). 3D 1060-nm OCT was performed over a 36° x 36° field of view with 7-µm axial resolution and up to 70 frames/s (512 A-scans/frame). ChT maps between ...
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    8. Robust segmentation of intraretinal layers in the normal human fovea using a novel statistical model based on texture and shape analysis

      Robust segmentation of intraretinal layers in the normal human fovea using a novel statistical model based on texture and shape analysis
      A novel statistical model based on texture and shape for fully automatic intraretinal layer segmentation of normal retinal tomograms obtained by a commercial 800nm optical coherence tomography (OCT) system is developed. While existing algorithms often fail dramatically due to strong speckle noise, non-optimal imaging conditions, shadows and other artefacts, the novel algorithm’s accuracy only slowly deteriorates when progressively increasing segmentation task difficulty. Evaluation against a large set of manual segmentations shows unprecedented robustness, even in the presence of additional strong speckle noise, with dynamic range tested down to 12dB, enabling segmentation of almost all intraretinal layers in cases previously ...
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    9. Three-dimensional 1060nm OCT: Choroidal thickness maps in normals and improved posterior segment visualization in cataract patients

      Three-dimensional 1060nm OCT: Choroidal thickness maps in normals and improved posterior segment visualization in cataract patients
      Purpose. To evaluate the performance and potential clinical role of 3D-1060nm-OCT by generating choroidal thickness (ChT) maps in patients of different age, ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. Methods. Axial lengths (AL) and 45° fundus photographs were acquired from 64 eyes (34 healthy subjects, 19-80 years, ametropia +3 to -10D). 3D-1060nm-OCT was performed over 36°x36° field of view with ~7µm axial resolution and up to 70 frames/second (512 A-scans/frame). ChT-maps between retinal pigment epithelium and the choroidal/scleral-interface, were generated and statistically analyzed. A further thirty ...
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    10. Wide-Field Optical Coherence Tomography of the Choroid In Vivo

      PURPOSE. To demonstrate high-speed, high axial resolution optical coherence tomography (OCT) at 1060 nm with penetration to the sclera. The clinical feasibility of dense, high-speed sampling for higher levels of detail at the macula and optic nerve head is explored with respect to motion artifacts. METHODS. A three-dimensional (3D) OCT system making use of a high-speed camera operating at 47,000 depth scans/s was developed. The 1010- to 1080-nm wavelength band leads to 6.7 µm effective axial resolution and enables the acquisition of retinal and choroidal 130 Megavoxel volumes of human subjects within 7 seconds. Motion artifacts were ...
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    11. Wide field optical coherence tomography of the choroid in vivo

      Purpose. To demonstrate high speed, high axial resolution optical coherence tomography (OCT) at 1060 nm with penetration to the sclera. The clinical feasibility of dense, high-speed sampling for higher level of detail at the macula and optic nerve head are exploited in respect to motion artifacts. Methods. A 3D-OCT system employing an InGaAs c...
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    1-11 of 11
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    1. (11 articles) Wolfgang Drexler
    2. (10 articles) Vedran Kajic
    3. (9 articles) Cardiff University
    4. (9 articles) Boris Považay
    5. (8 articles) Bernd M. Hofer
    6. (7 articles) Medical University of Vienna
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    Three-dimensional 1060nm OCT: Choroidal thickness maps in normals and improved posterior segment visualization in cataract patients Robust segmentation of intraretinal layers in the normal human fovea using a novel statistical model based on texture and shape analysis Three-Dimensional 1060-nm OCT: Choroidal Thickness Maps in Normal Subjects and Improved Posterior Segment Visualization in Cataract Patients Artefact reduction for cell migration visualization using spectral domain optical coherence tomography Mapping Choroidal and Retinal Thickness Variation in Type 2 Diabetes using Three-Dimensional 1060-nm Optical Coherence Tomography Automated choroidal segmentation of 1060 nm OCT in healthy and pathologic eyes using a statistical model Choroidal Thinning in Diabetes Type 1 Detected by 3-Dimensional 1060 nm Optical Coherence Tomography Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study