1. Articles from Shradha Prabhulkar

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    1. Optical coherence contrast imaging using gold nanorods in living mice eyes

      Optical coherence contrast imaging using gold nanorods in living mice eyes

      Background Optical Coherence Tomography (OCT) is a powerful imaging modality to visualize tissue structures, with axial image pixel resolution as high as 1.6 um in tissue. However, OCT is intrinsically limited to providing structural information as the OCT contrast is produced by optically scattering tissues. Methods Here we demonstrate gold nanorods (GNRs) injected into the anterior chamber (AC) and cornea of mice eyes can create a significant OCT signal and hence can be used as a contrast agent for in vivo OCT imaging. Results We show that a low dose of 30 nM of GNRs (13 nm in diameter ...

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    2. Molecular Histopathology Using Gold Nanorods and Optical Coherence Tomography

      Molecular Histopathology Using Gold Nanorods and Optical Coherence Tomography

      Purpose:To examine the novel application of a commercially available optical coherence tomography (OCT) system towards molecular histopathology using gold nanorod (GNR) linked antibodies as a functionalized contrast agent to evaluate ocular surface squamous neoplasia (OSSN). Methods:GNRs were synthesized and covalently attached to anti-glucose transporter-1 (GLUT-1) antibodies via carbodiimide chemistry. Three specimens from each of 3 distinct categories of human conjunctival tissue were selected for analysis, including conjunctiva without epithelial atypia (controls); conjunctival intraepithelial neoplasia: carcinoma in situ (CIS); and conjunctival squamous cell carcinoma (SCC). Tissue sections were incubated initially with GNR tagged anti-GLUT-1 antibodies and then with a ...

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    1. (2 articles) University of Miami
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