1. Articles from E. Frohman

    1-5 of 5
    1. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. Objective: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. Methods: A prospective multi-centre ( n = 13) study. Peripapillary ring scan QC rating of an OCT training set ( n = 50) was followed by a test set ( n = 50). Inter-rater agreement was calculated using kappa statistics. Results were ...

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    2. Associations between retinal nerve fiber layer abnormalities and optic nerve examination

      Associations between retinal nerve fiber layer abnormalities and optic nerve examination
      Objective: Retinal nerve fiber layer (RNFL) abnormalities detected by optical coherence tomography (OCT) are useful markers for axonal loss and visual dysfunction in multiple sclerosis (MS), but their role in routine clinical management is not well-studied. Methods: Clinical and OCT examinations were performed on 240 patients attending a neurology clinic. Using OCT 5th percentile to define abnormal RNFL thickness, we compared eyes classified by neurologists as having optic atrophy to RNFL thickness, and afferent pupillary defect (APD) to RNFL thickness ratios of eye pairs. Results: Mean RNFL thickness was less in eyes classified by neurologists as having optic atrophy (79 ...
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    3. Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies

      Objective: To evaluate the retinal nerve fiber layer (RNFL) thickness and macular volume in neuromyelitis optica (NMO) spectrum patients using optical coherence tomography (OCT). Background: OCT can quantify damage to retinal ganglion cell axons and can identify abnormalities in multiple sclerosis and optic neuritis (ON) eyes. OCT may also be useful in the evaluation of patients with NMO. Methods: OCT and visual function testing were performed in 26 NMO spectrum patients with a history of ON, 17 patients with isolated longitudinally extensive transverse myelitis (LETM) without ON, 378 patients with relapsing–remitting multiple sclerosis (RRMS), and 77 healthy controls at ...
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    4. Optical coherence tomography and disease subtype in multiple sclerosis.

      OBJECTIVE: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON). METHODS: RNFL thickness was measured in 326 MS and 94 control eyes using optical coherence tomography (OCT). MV and vision testing were done in a subset of the cohort. MS subtype was classified as relapsing-remitting (RRMS, n = 135), primary progressive (PPMS, n = 12), and secondary progressive (SPMS, n = 16). RESULTS: MS ON eyes had decreased RNFL thickness (84.2 microm) compared to controls (102.7 microm) (p PMID: 18040015 [PubMed - in ...
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    5. Optical coherence tomography and disease subtype in multiple sclerosis

      Objective: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON). Methods: RNFL thickness was measured in 326 MS and 94 control eyes using optical coherence tomography (OCT). MV and vision testing were done in a subset of the cohort. MS subtype was classified as relapsing-remitting (RRMS, n = 135), primary progressive (PPMS, n = 12), and secondary progressive (SPMS, n = 16). Results: MS ON eyes had decreased RNFL thickness (84.2 µm) compared to controls (102.7 µm) (p p p p p ...
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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Johns Hopkins University
    2. (5 articles) UT Southwestern Medical Center
    3. (5 articles) Peter A. Calabresi
    4. (5 articles) Laura J. Balcer
    5. (5 articles) Elliot M. Frohman
    6. (4 articles) University of Pennsylvania
    7. (2 articles) University of Alabama
    8. (2 articles) Gary R. Cutter
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