1. Articles from William Brown

    1-7 of 7
    1. Optical coherence tomography imaging systems and methods

      Optical coherence tomography imaging systems and methods

      Optical coherence tomography imaging systems and methods are disclosed. According to an aspect, an optical coherence tomography imaging system includes a scanner configured to obtain images and to convert the images to electrical signals. The system also includes a computing device comprising an OCT module configured to receive the electrical signals, to apply an OCT imaging technique, and to generate imaging data.

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    2. Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

      Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

      Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ . However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which demonstrate the utility of the combined measurements. In addition, future development and applications of this dual modality approach are discussed.

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    3. Scanning Laser Ophthalmoscopes

      Scanning Laser Ophthalmoscopes

      A scanning laser ophthalmoscope (SLO) for imaging the retina of an eye comprises a source ( 12 ) of collimated light, a scanning device ( 14, 16, 1328, 1319 ), a scan transfer device ( 20 ) and a detector ( 1310 ). The scan transfer device has a first focus ( 16 ) at which an apparent point source is provided and a second focus ( 24 ) at which an eye ( 524, 1324 ) may be accommodated. The scan transfer device transfers a two-dimensional collimated light scan from the apparent point source into the eye. An optical coherence tomography (OCT) system ( 900 ) is combined with the SLO, the OCT system providing ...

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      Mentions: Optos
    4. Functional optical coherence tomography: principles and progress

      Functional optical coherence tomography: principles and progress

      In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo human tissues. This review emphasizes the newer techniques of SOCT and molecular imaging OCT, which show excellent potential for clinical application but have yet to be well reviewed in the ...

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      Mentions: Duke University
    5. Optical Coherence Tomography Imaging Systems And Methods

      Optical Coherence Tomography Imaging Systems And Methods

      Optical coherence tomography imaging systems and methods are disclosed. According to an aspect, an optical coherence tomography imaging system includes a scanner configured to obtain images and to convert the images to electrical signals. The system also includes a computing device comprising an OCT module configured to receive the electrical signals, to apply an OCT imaging technique, and to generate imaging data.

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      Mentions: Lumedica
    6. Improvements In Or Relating To Scanning Laser Ophthalmoscopes

      Improvements In Or Relating To Scanning Laser Ophthalmoscopes

      A scanning laser ophthalmoscope (SLO) for imaging the retina of an eye comprises a source (12) of collimated light, a scanning device (14, 16, 1328, 1319), a scan transfer device (20) and a detector (1310). The scan transfer device has a first focus (16) at which an apparent point source is provided and a second focus (24) at which an eye (524, 1324) may be accommodated. The scan transfer device transfers a two-dimensional collimated light scan from the apparent point source into the eye. An optical coherence tomography (OCT) system (900) is combined with the SLO, the OCT system providing ...

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      Mentions: Optos
    7. Measuring neoplastic transformation in the hamster cheek pouch using Fourier domain low-coherence interferometry

      Robert N. Graf, Xiaoxin Chen, William Brown et al. Fourier Domain Low Coherence Interferometry (fLCI) is a promising technique which combines the depth resolution of low coherence interferometry with the sensitivity of light scattering spectroscopy for probing the health of epithelial tissue layers. Our new fLCI system configuration utilizes a white ... [Proc. SPIE Int. Soc. Opt. Eng. 6864, 68640P (2008)] published Fri Feb 15, 2008.
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      Mentions: Duke University
    1-7 of 7
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    1. (3 articles) Duke University
    2. (2 articles) Optos
    3. (2 articles) FDA
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    5. (1 articles) University of Wisconsin
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    Improvements In Or Relating To Scanning Laser Ophthalmoscopes Optical Coherence Tomography Imaging Systems And Methods Functional optical coherence tomography: principles and progress Scanning Laser Ophthalmoscopes Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography Optical coherence tomography imaging systems and methods Clinical Trials Critical for the Evaluation of Advanced Medical Imaging Tools Voxeleron Welcomes Manabu Tokunaga as new Director of Software Accuracy of Diabetic Retinopathy Staging with a Deep Convolutional Neural Network Using Ultra-Wide-Field Fundus Ophthalmoscopy and Optical Coherence Tomography Angiography A longitudinal comparison in cynomolgus macaques of the effect of brimonidine on optic nerve neuropathy using diffusion tensor imaging magnetic resonance imaging and spectral domain optical coherence tomography Design of 1300-nm spectral domain optical coherence tomography angiography system for iris microvascular imaging Perimeter Medical Imaging AI Announces Important Milestone in ATLAS AI Project with Standalone AI Algorithm Achieving Key Performance Metrics