1. Articles from Matthew Kupinski

    1-5 of 5
    1. Measurement of the lipid and aqueous layers of a tear film

      Measurement of the lipid and aqueous layers of a tear film

      Systems and methods for determining thickness of lipid and aqueous layers of a tear film in which a spectrum array is generated from optical coherence tomography and input into a statistical estimator, which determines the thickness of the lipid and/or aqueous layers at a nanometer resolution based on the inputted spectrum and other information, such as information about a laser intensity noise, Poisson noise, and dark noise associated with the OCT.

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    2. Measurement Of The Lipid And Aqueous Layers Of A Tear Film

      Measurement Of The Lipid And Aqueous Layers Of A Tear Film

      Systems and methods for determining thickness of lipid and aqueous layers of a tear film in which a spectrum array is generated from optical coherence tomography and input into a statistical estimator, which determines the thickness of the lipid and/or aqueous layers at a nanometer resolution based on the inputted spectrum and other information, such as information about a laser intensity noise, Poisson noise, and dark noise associated with the OCT

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    3. Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics

      Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics

      Understanding tear film dynamics is a prerequisite for advancing the management of Dry Eye Disease (DED). In this paper, we discuss the use of optical coherence tomography (OCT) and statistical decision theory to analyze the tear film dynamics of a digital phantom. We implement a maximum-likelihood (ML) estimator to interpret OCT data based on mathematical models of Fourier-Domain OCT and the tear film. With the methodology of task-based assessment, we quantify the tradeoffs among key imaging system parameters. We find, on the assumption that the broadband light source is characterized by circular Gaussian statistics, ML estimates of 40 nm +/− 4 ...

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    4. Phantom study of tear film dynamics with optical coherence tomography and maximum-likelihood estimation

      Phantom study of tear film dynamics with optical coherence tomography and maximum-likelihood estimation

      In this Letter, we implement a maximum-likelihood estimator to interpret optical coherence tomography (OCT) data for the first time, based on Fourier-domain OCT and a two-interface tear film model. We use the root mean square error as a figure of merit to quantify the system performance of estimating the tear film thickness. With the methodology of task-based assessment, we study the trade-off between system imaging speed (temporal resolution of the dynamics) and the precision of the estimation. Finally, the estimator is validated with a digital tear-film dynamics phantom

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    5. Quantitative Measurement of Tear Film Dynamics with Optical Coherence Tomography and Statistical Decision Theory

      Quantitative Measurement of Tear Film Dynamics with Optical Coherence Tomography and Statistical Decision Theory

      Currently, there are about 40 to 60 million Americans suffering from Dry Eye Syndrome (DES); this serious public health problem will worsen with the explosive aging population created by baby boomers, where DES has a high incidence. However, the therapeutics for DES are elusive because our understanding of DES is so elementary, especially the correlation between symptoms and the diagnosis. Unfortunately, a quantitative diagnosis, which is the prerequisite to advance the management of DES, is yet to be realized. We are seeking the next breakthrough in DES management by providing a quantitative diagnosis, with the combination of optical coherence tomography ...

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) University of Rochester
    2. (5 articles) Jannick P. Rolland
    3. (4 articles) University of Arizona
    4. (3 articles) Kye-Sung Lee
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    Quantitative Measurement of Tear Film Dynamics with Optical Coherence Tomography and Statistical Decision Theory Phantom study of tear film dynamics with optical coherence tomography and maximum-likelihood estimation Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics Measurement Of The Lipid And Aqueous Layers Of A Tear Film Measurement of the lipid and aqueous layers of a tear film Postdoctoral Fellow / Research Fellow at The Australian National University, Canberra Stress, anxiety, harassment: huge survey reveals pressures of scientists’ working lives Use of optical coherence tomography deemed feasible after first-in-human analysis Widefield Swept Source OCTA in Retinitis Pigmentosa Anterior segment optical coherence tomographic characterisation of keratic precipitate Vascular changes with optical coherence tomography angiography during aura of migraine: A case report Numerical method for axial motion artifact correction in retinal spectral-domain optical coherence tomography