1. Articles from Rajiv Gulati

    1-5 of 5
    1. Long-term darapladib use does not affect coronary plaque composition assessed using multimodality intravascular imaging modalities: a randomized-controlled study

      Long-term darapladib use does not affect coronary plaque composition assessed using multimodality intravascular imaging modalities: a randomized-controlled study

      Background Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) may play a role in plaque progression and vulnerability. We aimed to define plaque characteristics on multimodality intravascular imaging in patients with coronary endothelial dysfunction in response to long-term inhibition of Lp-PLA2 by darapladib. Patients and methods This is a double-blinded, randomized study screening 70 patients, and enrolling 54 patients with suspected ischemia, without obstructive disease on angiography and with coronary endothelial dysfunction by invasive assessment. Patients were randomized to receive darapladib or placebo for 6 months. Forty patients underwent multimodality intravascular imaging at baseline and after 6 months of therapy. Several parameters ...

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    2. Evaluation of Coronary Adventitial Vasa Vasorum Using 3D Optical Coherence Tomography - Animal and Human Studies

      Evaluation of Coronary Adventitial Vasa Vasorum Using 3D Optical Coherence Tomography - Animal and Human Studies

      Objectives This study sought to evaluate adventitial vasa vasorum (VV) in vivo with novel imaging technique of optical coherence tomography (OCT). Methods To verify OCT methods for quantification of VV, we first studied 2 swine carotid arteries in a model of focal angiogenesis by autologous blood injection, and compared microchannel volume (MCV) by OCT and VV by m-CT, and counts of those. In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border. After manually tracing microchannel areas and the boundaries of lumen-intima and media-adventitial in all slices, we reconstructed 3D ...

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    3. Coronary Endothelial Dysfunction Is Associated With Inflammation and Vasa Vasorum Proliferation in Patients With Early Atherosclerosis

      Coronary Endothelial Dysfunction Is Associated With Inflammation and Vasa Vasorum Proliferation in Patients With Early Atherosclerosis

      Objective— Endothelial dysfunction is an early manifestation of atherosclerosis . Inflammation and vasa vasorum play a pivotal role in the pathophysiology of plaque in itiation, development, and complications. Optical coherence tomography allows high-resolution imag in g of t is sue microstructure. Therefore, the aim of th is study was to test the hypothes is that segments with endothelial dysfunction show macrophages and vasa vasorum in patients with early coronary artery d is ease. Approach and Results— Optical coherence tomography images were obta in ed from 40 patients with mild coronary atherosclerosis who underwent coronary endothelial function assessment. Optical coherence tomography f ...

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    4. Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients: new insight into cardiac allograft vasculopathy by optical coherence tomography

      Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients: new insight into cardiac allograft vasculopathy by optical coherence tomography

      Aims Cardiac allograft vasculopathy (CAV) is a major limitation to long-term survival following cardiac transplantation. Conventional imaging modalities such as angiography and intravascular ultrasound fail to characterize CAV plaque morphology. Our aim was to characterize CAV in vivo using the high spatial resolution of intracoronary optical coherence tomography (OCT). Methods and results We prospectively enrolled 53 cardiac transplant patients to undergo OCT of the left anterior descending coronary artery (LAD) in addition to annual CAV screening by coronary angiography and intravascular ultrasound (IVUS). The proximal 30 mm of the LAD was divided into three segments of 10 mm each ( n ...

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    5. Angiographically silent very late stent thrombosis detected by optical coherence tomography in association with peri-stent staining and multiple interstrut cavities

      Angiographically silent very late stent thrombosis detected by optical coherence tomography in association with peri-stent staining and multiple interstrut cavities

      A 56-year-old-man had unstable angina 7 years previously, which was treated with two sirolimus-eluting stents (SESs) in the proximal and mid-left anterior descending artery (LAD) and one SES in a diagonal branch. Five years later, he developed stent thrombosis in the mid-LAD SES that required treatment with two additional everolimus-eluting stents ( Panel A , lines outline stents). Intravascular ultrasound confirmed that all

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    1-5 of 5
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  2. Topics in the News

    1. (4 articles) Amir Lerman
    2. (4 articles) Yoshiki Matsuo
    3. (3 articles) Abhiram Prasad
    4. (3 articles) National Institutes of Health
    5. (2 articles) Harvard University
    6. (1 articles) Ajou University
    7. (1 articles) Wakayama Medical University
    8. (1 articles) Texas A&M University
    9. (1 articles) FDA
    10. (1 articles) University of Southern California
    11. (1 articles) Dresden University of Technology
    12. (1 articles) Francesco Prati
    13. (1 articles) Edmund Koch
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    15. (1 articles) Javier A. Jo
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    Angiographically silent very late stent thrombosis detected by optical coherence tomography in association with peri-stent staining and multiple interstrut cavities Coronary atherosclerosis with vulnerable plaque and complicated lesions in transplant recipients: new insight into cardiac allograft vasculopathy by optical coherence tomography Coronary Endothelial Dysfunction Is Associated With Inflammation and Vasa Vasorum Proliferation in Patients With Early Atherosclerosis Evaluation of Coronary Adventitial Vasa Vasorum Using 3D Optical Coherence Tomography - Animal and Human Studies Long-term darapladib use does not affect coronary plaque composition assessed using multimodality intravascular imaging modalities: a randomized-controlled study Medical treatment of inflammatory punctual stenosis monitored by anterior segment optical coherence tomography Development and Validation of a Deep Learning System for Diagnosing Glaucoma Using Optical Coherence Tomography Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography Optical coherence tomography for thyroid pathology: 3D analysis of tissue microstructure Mathematical Analysis of Texture Indicators for the Segmentation of Optical Coherence Tomography Images Comparison of Current Optical Coherence Tomography Angiography Methods in Imaging Retinal Hemangioblastomas New findings useful for clinical practice using swept-source optical coherence tomography angiography in the follow-up of active ocular toxoplasmosis