1. Articles from Taiji Sakamoto

    1-24 of 32 1 2 »
    1. Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication

      Concerns about the interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication

      We read with great interest the correspondence in Lancet by Marinho et al. [ 1 ] describing purported retinal manifestations of coronavirus disease (COVID-19). While there is great interest to understand potential ocular complications of COVID-19 during this pandemic, we have some concerns regarding the interpretation of the fundus and optical coherence tomography (OCT) findings. Marinho et al. examined 12 COVID-19 patients (all confirmed by PCR or antibody testing) with typical systemic disease but no visual symptoms. The reported cohort was relatively young (25–69 years; no mean or median provided) without severe systemic disease, although 2 were hospitalized. Eleven of the ...

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    2. Quantitative analyses of diameter and running pattern of choroidal vessels in central serous chorioretinopathy by en face images

      Quantitative analyses of diameter and running pattern of choroidal vessels in central serous chorioretinopathy by en face images

      This study was to investigate the choroidal vessels in eyes with central serous chorioretinopathy (CSC) quantitatively. We studied 41 CSC eyes and their fellow eyes, and 41 normal eyes of 41 age-adjusted individuals. En-face optical coherence tomography image of the top 25% slab of Haller’s layer was analyze. The mean vessel area, vessel length, and vessel diameter were calculated. The running pattern of the vessels was quantified and used to determine the degree of symmetry, the “symmetry index”. The vessel area of CSC eyes was not significantly different from that of fellow eyes but significantly larger than that of ...

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      Mentions: Taiji Sakamoto
    3. Anterior Segment Optical Coherence Tomography in Ocular Argyrosis

      Anterior Segment Optical Coherence Tomography in Ocular Argyrosis

      Purpose The current study investigated differences in the peripapillary and macular choroidal areas between patients with primary open-angle glaucoma (POAG) and healthy controls because the choroid may potentially play a role in glaucoma pathophysiology. Methods We assessed 57 healthy controls and 42 POAG patients in a cross-sectional comparative study. We used enhanced depth imaging optical coherence tomography (EDI-OCT) and then converted the luminal and interstitial areas to binary images using the Niblack method to obtain peripapillary and macular choroidal images. The relationship between the choroidal area and demographic and ocular characteristics were determined with univariate and multivariate linear regression analysis ...

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    4. Assessment of primary open-angle glaucoma peripapillary and macular choroidal area using enhanced depth imaging optical coherence tomography

      Assessment of primary open-angle glaucoma peripapillary and macular choroidal area using enhanced depth imaging optical coherence tomography

      Purpose The current study investigated differences in the peripapillary and macular choroidal areas between patients with primary open-angle glaucoma (POAG) and healthy controls because the choroid may potentially play a role in glaucoma pathophysiology. Methods We assessed 57 healthy controls and 42 POAG patients in a cross-sectional comparative study. We used enhanced depth imaging optical coherence tomography (EDI-OCT) and then converted the luminal and interstitial areas to binary images using the Niblack method to obtain peripapillary and macular choroidal images. The relationship between the choroidal area and demographic and ocular characteristics were determined with univariate and multivariate linear regression analysis ...

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    5. Correlations Between Choroidal Structures And Visual Functions In Eyes With Retinitis Pigmentosa

      Correlations Between Choroidal Structures And Visual Functions In Eyes With Retinitis Pigmentosa

      Purpose: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. Methods: The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length–matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500- µ m width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer ...

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    6. Systemic and Ocular Determinants of Choroidal Structures on Optical Coherence Tomography of Eyes with Diabetes and Diabetic Retinopathy

      Systemic and Ocular Determinants of Choroidal Structures on Optical Coherence Tomography of Eyes with Diabetes and Diabetic Retinopathy

      Knowledge of the choroidal structures in eyes with diabetes and diabetic retinopathy (DR) should provide information on the pathogenesis of DR. A prospective study was performed to determine the systemic and ocular factors that affect the choroidal structures in eyes with diabetes. Two-hundred consecutive diabetic subjects consisted of 160 treatment-naïve patients with different stages of DR and 40 patients with proliferative DR with prior panretinal photocoagulation (PRP). All underwent blood and urine tests and enhanced depth imaging optical coherence tomography (EDI-OCT). The cross-sectional EDI-OCT images of the subfoveal choroid were binarized to measure the total choroidal area (TCA), luminal ...

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      Mentions: Taiji Sakamoto
    7. Regional Differences of Choroidal Structure Determined by Wide-Field Optical Coherence Tomography

      Regional Differences of Choroidal Structure Determined by Wide-Field Optical Coherence Tomography

      Purpose : To compare the submacular to the perimacular choroidal structure in images obtained by wide-field optical coherence tomography (OCT). Methods : Thirty eyes of 30 healthy volunteers (15 men) were studied. Twelve wide-field radial circumferential scans were recorded with enhanced depth imaging OCT from the macular and perimacular zones. The sizes of the luminal and stromal areas of the choroid were determined. The two zones were subdivided into the superior, inferior, nasal, and temporal sectors. The total choroidal area, the luminal and stromal areas, and the luminal ratio of each sector were compared. Results : All of the choroidal structural parameters analyzed ...

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    8. Automated segmentation of en face choroidal images obtained by optical coherent tomography by machine learning

      Automated segmentation of en face choroidal images obtained by optical coherent tomography by machine learning

      Purpose To develop an automated method to segment the choroidal layers of en face optical coherent tomography (OCT) images by machine learning. Study design A cross-sectional, prospective study of 276 eyes of 181 healthy subjects. Methods OCT en face images of the choroid were obtained every 2.6 μm from the retinal pigment epithelium (RPE) to the chorioscleral border. The images at the start of the choriocapillaris, start of Sattler’s layer, and start of Haller’s layer were identified, and the image numbers from the RPE line were taken as the teacher data. Forty-one feature quantities of each image ...

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      Mentions: Taiji Sakamoto
    9. Objective evaluation of size and shape of superficial foveal avascular zone in normal subjects by optical coherence tomography angiography

      Objective evaluation of size and shape of superficial foveal avascular zone in normal subjects by optical coherence tomography angiography

      This study was conducted to investigate the size and shape of the foveal avascular zone (FAZ) determined by optical coherence tomography angiography (OCTA) and the relationship of the size and shape to the clinical findings in normal subjects. This was a cross-sectional study with seventy eyes of 70 volunteers. The size of the superficial FAZs were assessed by its area, length of perimeter, and Feret’s diameter, and the shape by the circularity, axial ratio, roundness, and solidity. The correlations between each parameter and the clinical findings were statistically determined. The coefficients of variation (CV) of the parameters of FAZ ...

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      Mentions: Taiji Sakamoto
    10. Evaluation of Shape of Foveal Avascular Zone by Optical Coherence Tomography Angiography in Eyes With Branch Retinal Vein Occlusion

      Evaluation of Shape of Foveal Avascular Zone by Optical Coherence Tomography Angiography in Eyes With Branch Retinal Vein Occlusion

      Purpose: To determine the relationship between morphological parameters of the foveal avascular zone (FAZ) in the optical coherence tomography angiographic (OCTA) images and the best-corrected visual acuity (BCVA) in branch retinal vein occlusion (BRVO). Methods: This was a retrospective cross-sectional study. Eyes with BRVO without apparent macular edema were studied. The superficial FAZ in 3 × 3 mm OCTA images were delineated manually. The size and shape, the circularity and axial ratio, of the FAZ were determined, and the values were compared to that of the controls. The correlation of these parameters with the BCVA was analyzed. Results: The mean FAZ ...

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      Mentions: Taiji Sakamoto
    11. Comparison of Choroidal Vascularity Markers on Optical Coherence Tomography Using Two-Image Binarization Techniques

      Comparison of Choroidal Vascularity Markers on Optical Coherence Tomography Using Two-Image Binarization Techniques

      Purpose : To compare the agreement between optical coherence tomography (OCT)-based choroidal vascularity markers measured by two previously reported image binarization techniques. Methods : Spectral-domain OCT using enhanced-depth imaging was performed in 100 eyes from 52 normal subjects. Choroidal images were binarized to luminal area and stromal area using two different algorithms. Choroidal vascularity marker was defined as the ratio of luminal area to total choroidal area and they were termed “luminal/choroidal area ratio (L/C ratio)” and “choroidal vascularity index (CVI)” per the algorithm. The agreement between choroidal vascularity markers measured by the two techniques was compared using intraclass ...

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      Mentions: Taiji Sakamoto
    12. Semi-automated software to measure luminal and stromal areas of choroid in optical coherence tomographic images

      Semi-automated software to measure luminal and stromal areas of choroid in optical coherence tomographic images

      Purpose To determine the capabilities of “EyeGround” software in measuring the choroidal cross sectional areas in optical coherence tomographic (OCT) images. Study design Cross sectional, prospective study. Methods The cross-sectional area of the subfoveal choroid within a 1500 µm diameter circle centered on the fovea was measured both with and without using the EyeGround software in the OCT images. The differences between the evaluation times and the results of the measurements were compared. The inter-rater, intra-rater, inter-method agreements were determined. Results Fifty-one eyes of 51 healthy subjects were studied: 24 men and 27 women with an average age of 35 ...

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      Mentions: Taiji Sakamoto
    13. Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

      Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

      Optical coherence tomography (OCT) has made it possible for clinicians to measure the peripapillary choroidal thickness (ppCT) noninvasively in various ocular diseases. However, the ocular factors associated with the ppCT have not been conclusively determined. The purpose of this study was to determine the relationship between the local ppCT and the axial length, optic disc tilt, and the angle of the papillo-macular position (PMP) in healthy eyes. This was a prospective, observational cross-sectional study of 119 right eyes of 119 healthy Japanese volunteers. The ppCT was manually measured at eight sectors around the optic disc using the B-scan images of ...

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    14. Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy

      Optical Coherence Tomography Angiography for Detecting Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy

      Punctate inner choroidopathy (PIC) is a relatively uncommon inflammatory multifocal chorioretinopathy that predominantly affects young, myopic women. Subfoveal choroidal neovascularization (CNV) often leads to rapid loss of sight. Fluorescein angiography (FA) and indocyanine green angiography (ICGA) remain the existing gold standards for CNV diagnosis. However, these methods are invasive and time-consuming. Recently, optical coherence tomography angiography (OCTA) has been used more frequently as an adjunct to FA/ICGA. In this report, a 38-year-old woman with PIC and idiopathic CNV presented with blurred vision despite 18/20 visual acuity. FA revealed positive staining and possible leakage, but did not provide clear ...

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    15. Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images

      Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images

      Purpose To compare the choroidal structure of the subfoveal area in the eyes of children with anisohypermetropic amblyopia to that of the fellow eyes and to age-matched controls using a binarization method of the images obtained by enhanced depth imaging optical coherence tomography (EDI-OCT). Methods This study was performed at Nara Medical University Hospital, Tokushima University Hospital, and Kagoshima University Hospital, Japan. Forty amblyopic eyes with anisohypermetropic amblyopia and their fellow eyes (5.9 ± 2.1 years, mean ± standard deviation), and 103 age-matched controls (6.7 ± 2.4 years) were studied. The control eyes were divided into myopic, emmetropic, and ...

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    16. Minification of fundus optical coherence tomographic images in gas-filled eye

      Minification of fundus optical coherence tomographic images in gas-filled eye

      Background Optical coherence tomography (OCT) is being used increasingly to evaluate and manage a variety of retinal diseases, but not much is known about the minification of the OCT images in gas-filled eyes. The purpose of this study was to investigate the effect of gas-filled eyes on the size of the OCT images. Methods This was retrospective case series of 81 consecutive eyes of 79 patients who had macular hole surgery between April 2012 and September 2014. Images of the optic disc were taken with a spectral domain-OCT instrument 2 days after surgery in gas-filled, pseudophakic eyes and from the ...

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    17. Structural Changes of Inner and Outer Choroid in Central Serous Chorioretinopathy Determined by Optical Coherence Tomography

      Structural Changes of Inner and Outer Choroid in Central Serous Chorioretinopathy Determined by Optical Coherence Tomography

      Purpose To determine the structural changes of the choroid in eyes with central serous chorioretinopathy (CSC) by enhanced depth imaging optical coherence tomography (EDI-OCT). Methods A retrospective comparative study was performed at two academic institutions. Forty eyes with CSC, their fellow eyes, and 40 eyes of age-matched controls were studied. Subfoveal cross sectional EDI-OCT images were recorded, and the hypo reflective and hyperreflective areas of the inner and outer choroid in the EDI-OCT images were separately measured. The images were analyzed by a binarization method to determine the sizes of the hyporeflective and hyperreflective areas. Results In the inner choroid ...

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      Mentions: Taiji Sakamoto
    18. Binarization of enhanced depth imaging optical coherence tomographic images of an eye with Wyburn-Mason syndrome: a case report

      Binarization of enhanced depth imaging optical coherence tomographic images of an eye with Wyburn-Mason syndrome: a case report

      Background To report a thicker choroid and larger choroidal luminal area in an eye with Wyburn-Mason syndrome. To the best of our knowledge, this is the first report demonstrating an increase in the choroidal thickness and the luminal area in a case of Wyburn-Mason syndrome. In addition, we report the changing appearance of retinal arteriovenous malformations over a 16-year period. Case presentation A 27-year-old woman, who was diagnosed with Wyburn-Mason syndrome at age 11 years, visited our clinic. Her best-corrected visual acuity was 20/12.5 in the right eye and light perception in the left eye. Severely dilated, tortuous ...

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    19. Blood Components and OCT Reflectivity Evaluated in Animal Model

      Blood Components and OCT Reflectivity Evaluated in Animal Model

      Background/purpose : To see the relationship between blood components and optical coherence tomography ( OCT ) reflectivity using an animal model in which the aqueous humor was substituted by different experimental solutions without changing the integrity of the retina. Materials and methods : The aqueous humor of an enucleated swine eye was replaced with plasma obtained from healthy volunteers. The OCT reflectivity of the anterior chamber filled with each plasma was calculated from individual OCT images, and was expressed by an arbitrary unit (AU). The concentration of blood components such as cholesterol, hemoglobin (Hb) and bilirubin of each individual was measured, and the ...

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      Mentions: Taiji Sakamoto
    20. Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images

      Purpose. To determine changes in choroidal structure by binarization of optical coherence tomographic (OCT) images. Methods. Choroidal images were recorded by enhanced depth imaging OCT. The subfoveal choroidal images were analyzed, and the luminal and interstitial areas were converted to binary images by the Niblack method. The interrater, intrarater, and intersession agreements of the binary images were determined for healthy eyes. In eyes with age-related macular degeneration (AMD), the binary images of the choroid before photodynamic therapy (PDT) were compared to those after PDT. The untreated fellow eyes were studied as controls. Results. In healthy eyes, the average ratio of ...

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      Mentions: Taiji Sakamoto
    21. Comparisons of Choroidal Thickness of Normal Eyes Obtained by Two Different Spectral-Domain OCT Instruments and One Swept-Source OCT Instrument

      Comparisons of Choroidal Thickness of Normal Eyes Obtained by Two Different Spectral-Domain OCT Instruments and One Swept-Source OCT Instrument

      Purpose. We compared the subfoveal choroidal thickness (SFCT) measured on the images obtained by two spectral-domain optical coherence tomographic (SD-OCT) instruments and one swept-source OCT (SS-OCT) instrument. Methods. A cross-sectional, prospective noninterventional study was done in which SFCT was measured in the images obtained by two SD-OCT instruments; Heidelberg Spectralis-OCT (Spectralis-SD-OCT) and Topcon 3D OCT-1000 Mark II (Topcon-SD-OCT). Images also were obtained with SS-OCT Atlantis DRI OCT-1 (DRI-SS-OCT). After manual segmentation, the measurements were made using the calipers embedded in each instrument. The intrarater, interrater, and intermachine agreements were assessed. Results. We studied 35 subjects. The intrarater correlation coefficient (95 ...

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    22. Association between retinal thickness of 64 sectors in posterior pole determined by optical coherence tomography and axial length and body height

      Association between retinal thickness of 64 sectors in posterior pole determined by optical coherence tomography and axial length and body height

      PURPOSE: To determine a significant correlation between the retinal thickness (RT) in 64 cells or sectors of the posterior pole and the axial length (AL) and the body height (BH). METHODS: A prospective, observational cross sectional study of 64 right eyes of 64 healthy volunteers (mean age 26.0 ± 4.5 years; range, 22 to 39 years). The RT within the central 24° area was measured in the Spectralis spectral domain-optical coherence tomographic (SD-OCT) images. The correlations between the RT and the AL or the BH were determined by linear regression analyses. RESULTS: The mean ± standard deviation of the AL ...

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      Mentions: Taiji Sakamoto
    23. Early structural changes during spontaneous closure of idiopathic full-thickness macular hole determined by optical coherence tomography: a case report

      Early structural changes during spontaneous closure of idiopathic full-thickness macular hole determined by optical coherence tomography: a case report

      Background Spontaneous closure of an idiopathic full-thickness macular hole has been reported to occasionally occur. However, the cells involved in plugging the macular hole have not been determined conclusively. We aimed to report the early structural changes that occur during a spontaneous closure of an idiopathic full-thickness macular hole determined by spectral-domain optical coherence tomography. Case presentation A 71-year-old Japanese man with an idiopathic full-thickness macular hole and subclinical posterior vitreous detachment in the left eye was followed. Three weeks after the identification of the macular hole, optical coherence tomography showed tissue that protruded from the interior wall of the ...

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    24. Correlation Between Reflectivity of Subretinal Fluid in OCT Images and Concentration of Intravitreal VEGF in Eyes With Diabetic Macular Edema

      Correlation Between Reflectivity of Subretinal Fluid in OCT Images and Concentration of Intravitreal VEGF in Eyes With Diabetic Macular Edema

      Purpose. The reflectivity of optical coherence tomographic (OCT) images has been used to evaluate retinal diseases. The purpose of our study was to determine whether a significant correlation exists between the reflectivity of the subretinal fluid (SRF) and the concentration of intravitreal cytokines in eyes with diabetic macular edema (DME). Methods. A retrospective comparative study was done of eyes with DME with SRF before vitrectomy. The reflectivity of the SRF was determined from the OCT images. Vitreous samples were collected during vitrectomy, and analyzed for the concentrations of VEGF, IL-6, and IL-8. To determine the factors in the SRF that ...

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      Mentions: Taiji Sakamoto
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