1. Articles from David Nolte

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    1. Live tissue viability and chemosensitivity assays using digital holographic motility contrast imaging

      Live tissue viability and chemosensitivity assays using digital holographic motility contrast imaging

      Holographic optical coherence imaging is an en face form of optical coherence tomography that uses low-coherence digital holography as a coherence gate to select light from a chosen depth inside scattering tissue. By acquiring successive holograms at a high camera frame rate at a fixed depth, dynamic speckle provides information concerning dynamic light scattering from intracellular motility. Motility contrast imaging (MCI) uses living motion as a label-free and functional biomarker. MCI provides a new form of viability assay and also is applicable for proliferation and cytotoxicity assays. The results presented here demonstrate that low-coherence digital holography can extract viability information ...

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    1. (3 articles) National Institutes of Health
    2. (1 articles) Purdue University
    3. (1 articles) Indiana University
    4. (1 articles) University of Erlangen
    5. (1 articles) Peking University
    6. (1 articles) Universidade Federal de São Paulo
    7. (1 articles) Massachusetts Institute of Technology
    8. (1 articles) Joel Ramjist
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    12. (1 articles) Heidelberg Spectralis
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