1. Articles from Chien-Chih Lai

    1-5 of 5
    1. Feature Of The Week 10/21/12: Cell Death Detection by Quantitative Three-Dimensional Single-Cell Tomography

      Feature Of The Week 10/21/12: Cell Death Detection by Quantitative Three-Dimensional Single-Cell Tomography


      The aim of cancer therapies is mainly to stop cell proliferation or induce cell death. Cell death regulation is important for normal development and homeostasis. Cancer cells escape from death signals and continue their abnormal proliferation. Therefore, the ability to induce death in cancer cells has been a crucial biomarker for the efficacy of chemotherapeutic agents. However, individual cancer cells, even from the same population, vary greatly in their response to cell death stimuli. Measuring the response at the single-cell levels provide further pharmacokinetic and pharmacodynamics information, which aids drug development and regimen design. Developing a microscopic technology with non-invasive ...

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    2. Cell death detection by quantitative three-dimensional single-cell tomography

      Cell death detection by quantitative three-dimensional single-cell tomography

      Ultrahigh-resolution optical coherence tomography (UR-OCT) has been used for the first time to our knowledge to study single-cell basal cell carcinoma (BCC) in vitro. This noninvasive, in situ, label-free technique with deep imaging depth enables three-dimensional analysis of scattering properties of single cells with cellular spatial resolution. From three-dimensional UR-OCT imaging, live and dead BCC cells can be easily identified based on morphological observation. We developed a novel method to automatically extract characteristic parameters of a single cell from data volume, and quantitative comparison and parametric analysis were performed. The results demonstrate the capability of UR-OCT to detect cell death ...

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    3. Diode-Laser-Pumped Glass-Clad Ti:Sapphire Crystal-Fiber-Based Broadband Light Source

      Diode-Laser-Pumped Glass-Clad Ti:Sapphire Crystal-Fiber-Based Broadband Light Source

      Glass-clad TiAlO3 crystal fibers were grown using the codrawing laser-heated pedestal growth method. Both single-clad and double-clad structures were attempted. Using a 446-nm laser diode as the pump, 2.45 mW of collimated broadband emission was generated with a 3-dB bandwidth of 180 nm. As much as 7.7 mW of output power with a 3-dB bandwidth of 182 nm was generated using a 532-nm solid-state pump laser. The broadband light source is advantageous to use in optical coherence tomography with an axial resolution of 1.5 um in air and a low image pixel crosstalk.

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    4. Near-Field Spectroscopy of Broadband Emissions from γ-Al2O3 Nanocrystals in Cr-Doped Double-Clad Fibers

      Near-Field Spectroscopy of Broadband Emissions from γ-Al2O3 Nanocrystals in Cr-Doped Double-Clad Fibers
      Embedded nanocrystals (NCs) of γ-Al2O3 in SiO2 matrixes of Cr-doped double-clad fibers (CDFs) were fabricated by the codrawing laser-heated pedestal growth technique. The spatially resolved broadband emissions of these NCs were examined as a function of NC morphology and distribution by near-field scanning optical microscopy. Comparison of the measured emissions with crystal-field ligands together with careful examination of the NC morphologies by high-resolution transmission electron microscopy confirmed this broadband emission as being an effect of nanotwinning and the Cr3+–Cr6+ redox reaction. The impact of nanotwinning on the relative strength and emission wavelength of Cr3+ and Cr6+ is potentially beneficial ...
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    5. Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel

      Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel
      e microstructural and microspectral characteristics of a vertically aligned liquid crystal display (VA-LCD) panel were obtained noninvasively for the first time. With 1 μm axial and 2 μm transversal resolutions, the cell gap profile beneath the patterned thin-film transistor of the VA-LCD panel can clearly be resolved. The thicknesses of the multiple thin-film layers and the embedded defects can also be unveiled. As far as spectral response is concerned, the light transmittance at the layer boundaries can be estimated from the measured reflectance, which is crucial information for the design of a highly transmissive panel. The color shift of the ...
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    1-5 of 5
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    1. (5 articles) National Taiwan University
    2. (1 articles) University of Bologna
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    Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel Near-Field Spectroscopy of Broadband Emissions from γ-Al2O3 Nanocrystals in Cr-Doped Double-Clad Fibers Diode-Laser-Pumped Glass-Clad Ti:Sapphire Crystal-Fiber-Based Broadband Light Source Cell death detection by quantitative three-dimensional single-cell tomography Feature Of The Week 10/21/12: Cell Death Detection by Quantitative Three-Dimensional Single-Cell Tomography Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study The Use of Optical Coherence Tomography to Demonstrate Dark and Light Adaptation in a Live Moth