1. Articles from Alex Yuan

    1-10 of 10
    1. Twenty-Four-Month OCTA Assessment in Diabetic Patients Undergoing Fixed-Interval Intravitreal Aflibercept Therapy

      Twenty-Four-Month OCTA Assessment in Diabetic Patients Undergoing Fixed-Interval Intravitreal Aflibercept Therapy

      BACKGROUND AND OBJECTIVE: Evaluate capillary perfusion density (CPD) in patients with diabetic macular edema (DME) undergoing fixed intravit-real aflibercept injections (IAI) through 24 months. PATIENTS AND METHODS: Prospective, interventional, single-arm study enrolling 20 patients with persistent DME. Patients received IAI every 4 weeks until DME resolution followed by extension to every 8 weeks. Optical coherence tomography angiography was obtained at baseline, 6, 12, and 24 months. RESULTS: Sixteen of 20 eyes completed the study. Baseline mean central subfield thickness was 420 µm, which improved to 251 µm ( P < .001). The mean best-corrected visual acuity (BCVA) improved by 5.5 letters ...

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      Mentions: Cleveland Clinic
    2. The DISCOVER Study 3-Year Results

      The DISCOVER Study 3-Year Results

      Purpose To report the 3-year assessment of feasibility and usefulness of microscope-integrated intraoperative OCT (iOCT) during ophthalmic surgery. Design Prospective, consecutive case series. Participants Adult participants undergoing incisional ophthalmic surgery with iOCT imaging who consented to be enrolled in the Determination of Feasibility of Intraoperative Spectral-Domain Microscope Combined/Integrated OCT Visualization during En Face Retinal and Ophthalmic Surgery (DISCOVER) study. Methods The DISCOVER study is a single-site, multisurgeon, institutional review board-approved investigational device prospective study. Participants included patients undergoing anterior or posterior segment surgery who underwent iOCT imaging with 1 of 3 prototype microscope-integrated iOCT systems (i.e., Zeiss Rescan ...

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    3. The adult zebrafish retina: In vivo optical sectioning with Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography

      The adult zebrafish retina: In vivo optical sectioning with Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography

      Non-invasive imaging is an invaluable diagnostic tool in ophthalmology. Two imaging devices, the scanning laser ophthalmoscope (SLO) and spectral domain optical coherence tomography (SDOCT), emerged from the clinical realm to provide research scientists with a real-time view of ocular morphology in living animals. We utilized these two independent imaging modalities in a complementary manner to perform in vivo optical sectioning of the adult zebrafish retina. Due to the very high optical power of the zebrafish lens, the confocal depth of field is narrow, allowing for detailed en face views of specific retinal layers, including the cone mosaic. Moreover, we demonstrate ...

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    4. The Feasibility of Spectral-Domain Optical Coherence Tomography Grading of Anterior Chamber Inflammation in a Rabbit Model of Anterior Uveitis

      The Feasibility of Spectral-Domain Optical Coherence Tomography Grading of Anterior Chamber Inflammation in a Rabbit Model of Anterior Uveitis

      Purpose : To determine the feasibility and accuracy of spectral-domain optical coherence tomography (SD-OCT) based grading of anterior chamber cell, using aqueous sampling as a standard, in a rabbit model of anterior uveitis. Methods : Adult Dutch-belted rabbits were preimmunized with M. tuberculosis (Tb) H37RA antigen, 1 week prior to induction of anterior uveitis with an intracameral injection of Tb antigen. The anterior chamber was imaged with SD-OCT, followed by a slit lamp examination. Two independent, trained graders recorded their estimate of anterior chamber cell count using the Standardization of Uveitis Nomenclature (SUN) scores for each eye prior to performing an anterior ...

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      Mentions: Cleveland Clinic
    5. Optical coherence tomography of outer retinal holes in senile retinoschisis and schisis-detachment

      Optical coherence tomography of outer retinal holes in senile retinoschisis and schisis-detachment

      Purpose On clinical examination, it can be challenging to differentiate retinoschisis with outer retinal hole from schisis-detachment. This study examined the role of outer retinal hole spectral domain optical coherence tomography (SD-OCT) imaging in conjunction with imaging of the posterior schisis cavity edge in differentiating between these conditions. Methods This is a retrospective case series. Out of 500 subjects with ICD-9 diagnoses of senile retinoschisis (361.10, 361.11, 361.12, 361.19) from January 2004 to December 2014, 62 had evidence of retinoschisis on fundus photography or optical coherence tomography (OCT). Six eyes of five patients had outer retinal ...

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    6. Retinal Regeneration Following OCT-guided Laser Injury in Zebrafish

      Retinal Regeneration Following OCT-guided Laser Injury in Zebrafish

      Purpose: Establish a focal injury/regeneration model in zebrafish using laser photocoagulation guided by optical coherence tomography (OCT). Methods: Adult zebrafish were imaged by OCT and confocal scanning laser ophthalmoscopy (cSLO) in room air through a contact lens. Using a beam combiner, 532nm laser photocoagulation was applied using the OCT C-scan image for targeting. Laser spots of 42-47mW were delivered to the retina. At multiple intervals post-injury, fish were imaged using both OCT and cSLO to follow the progression of each lesion. Histologic sections and TUNEL staining were performed to monitor the injury response. Results: Round lesions (26057 ± 621μm2 ...

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    7. TRANS-TAMPONADE OPTICAL COHERENCE TOMOGRAPHY: Postoperative Imaging in Gas-Filled Eyes

      TRANS-TAMPONADE OPTICAL COHERENCE TOMOGRAPHY: Postoperative Imaging in Gas-Filled Eyes

      Purpose: To investigate the feasibility of trans-tamponade optical coherence tomography and evaluate factors contributing to image quality and acquisition success. Methods: Retrospective case series of eyes receiving Postoperative Day 1 optical coherence tomography imaging after vitrectomy and gas tamponade. The quality of the scans was graded by three independent expert readers. Clinical and surgical variables were recorded and correlated with scan quality. Results: Eighty eyes were included in the study. An image quality classification scheme was developed (0-4, 0 = no image and 4 = comparable quality to trans-fluid optical coherence tomography). In 51 scans (64%), visualization of the inner retina and ...

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      Mentions: Cleveland Clinic
    8. Retinal and Choroidal Findings in Oxalate Retinopathy Using EDI-OCT

      Retinal and Choroidal Findings in Oxalate Retinopathy Using EDI-OCT

      A 55-year-old woman with extensive retinal crystalline deposition secondary to primary hyperoxaluria presented with bilateral loss of vision secondary to oxalate retinopathy. Enhanced depth imaging optical coherence tomography revealed intraretinal, subretinal, and intraretinal and subretinal pigment epithelium, and choroidal focal hyperreflective structures consistent with both neurosensory and uveal deposition of oxalate crystals. Serial optical coherence tomography revealed continued crystalline deposition with progressive retinal atrophy.

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    9. A Novel Segmentation Algorithm for Volumetric Analysis of Macular Hole Boundaries Identified with Optical Coherence Tomography

      A Novel Segmentation Algorithm for Volumetric Analysis of Macular Hole Boundaries Identified with Optical Coherence Tomography

      To demonstrate a novel algorithm for macular hole (MH) segmentation and volumetric analysis. Methods: An computer algorithm was developed for automated MH segmentation in spectral domain optical coherence tomography (SD-OCT). Algorithm validation was performed by trained graders with performance characterized by absolute accuracy and intraclass correlation coefficient. A retrospective, case series of 56 eyes of 55 patients with idiopathic MH analyzed using the custom algorithm to measure MH volume, base area/diameter, top area/diameter, minimum diameter, and height-to-base diameter ratio. Five eyes were excluded due to poor signal quality (1), motion artifact (1), and failure of surgical closure (3 ...

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      Mentions: Cleveland Clinic
    10. Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography

      Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography

      Objective To describe the choroidal characteristics of patients with retinitis pigmentosa (RP) using enhanced depth imaging (EDI) and spectral domain (SD) optical coherence tomography (OCT). Purpose To investigate the spectral-domain ocular coherence tomography features of the choroid in patients with RP using EDI. Methods A prospective, case–control study of 21 patients from the Cole Eye Institute with RP imaged using the Spectralis OCT and an EDI protocol. Submacular choroidal thickness measurements were obtained beneath the fovea and at 500 µm intervals for 2.5 mm nasal and temporal to the centre of the fovea. These measurements were compared to ...

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      Mentions: Cleveland Clinic
    1-10 of 10
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    Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography A Novel Segmentation Algorithm for Volumetric Analysis of Macular Hole Boundaries Identified with Optical Coherence Tomography Retinal and Choroidal Findings in Oxalate Retinopathy Using EDI-OCT TRANS-TAMPONADE OPTICAL COHERENCE TOMOGRAPHY: Postoperative Imaging in Gas-Filled Eyes Retinal Regeneration Following OCT-guided Laser Injury in Zebrafish Optical coherence tomography of outer retinal holes in senile retinoschisis and schisis-detachment The Feasibility of Spectral-Domain Optical Coherence Tomography Grading of Anterior Chamber Inflammation in a Rabbit Model of Anterior Uveitis The adult zebrafish retina: In vivo optical sectioning with Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography The DISCOVER Study 3-Year Results Twenty-Four-Month OCTA Assessment in Diabetic Patients Undergoing Fixed-Interval Intravitreal Aflibercept Therapy Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea