1. Articles from Kenneth S. Suslick

    1-5 of 5
    1. Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Representative magnetomotive signal (green) using targeted and non-targeted magnetomotive microspheres in atherosclerotic diseased rabbit aortas. We report the development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV-MM-OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a ...

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    2. Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using αvβ 3 Integrin-Targeted Microspheres

      Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using αvβ 3 Integrin-Targeted Microspheres

      Purpose We investigated the early-stage fatty streaks/plaques detection using magnetomotive optical coherence tomography (MM-OCT) in conjunction with α v β 3 integrin-targeted magnetic microspheres (MSs). The targeting of functionalized MSs was investigated by perfusing ex vivo aortas from an atherosclerotic rabbit model in a custom-designed flow chamber at physiologically relevant pulsatile flow rates and pressures. Procedures Aortas were extracted and placed in a flow chamber. Magnetic MS contrast agents were perfused through the aortas and MM-OCT, fluorescence confocal, and bright field microscopy were performed on the ex vivo aorta specimens for localizing the MSs. Results The results showed a statistically significant ...

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    3. Targeted Multifunctional Multimodal Protein-Shell Microspheres as Cancer Imaging Contrast Agents

      Targeted Multifunctional Multimodal Protein-Shell Microspheres as Cancer Imaging Contrast Agents

      Purpose In this study, protein-shell microspheres filled with a suspension of iron oxide nanoparticles in oil are demonstrated as multimodal contrast agents in magnetic resonance imaging (MRI), magnetomotive optical coherence tomography (MM-OCT), and ultrasound imaging. The development, characterization, and use of multifunctional multimodal microspheres are described for targeted contrast and therapeutic applications. Procedures A preclinical rat model was used to demonstrate the feasibility of the multimodal multifunctional microspheres as contrast agents in ultrasound, MM-OCT and MRI. Microspheres were functionalized with the RGD peptide ligand, which is targeted to αvβ3 integrin receptors that are over-expressed in tumors and atherosclerotic lesions ...

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    4. Magnetic protein microspheres as dynamic contrast agents for magnetomotive optical coherence tomography

      Freddy T. Nguyen, Elizabeth M. Dibbern, Eric J. Chaney et al. Optical coherence tomography (OCT) is an emerging biomedical imaging modality that has been developed over the last 15 years. More recently, OCT has been used for the intraoperative imaging of tumor margins in breast cancer and axillary lymph nodes providing a real time in-vivo assessment of the tis ... [Proc. SPIE Int. Soc. Opt. Eng. 6867, 68670F (2008)] published Wed Feb 13, 2008.
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    5. Optical contrast agents for optically modifying incident radiation

      A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and microparticles. The enhancement is particularly suitable for optical coherence tomography.

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) University of Illinois at Urbana-Champaign
    2. (5 articles) Stephen A. Boppart
    3. (4 articles) Eric J. Chaney
    4. (3 articles) Marina Marjanovic
    5. (2 articles) Adeel Ahmad
    6. (1 articles) Samsung
    7. (1 articles) National Institutes of Health
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    12. (1 articles) Johns Hopkins University
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    15. (1 articles) University of São Paulo
    16. (1 articles) Massachusetts Institute of Technology
    17. (1 articles) L V Prasad Eye Institute
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    Targeted Multifunctional Multimodal Protein-Shell Microspheres as Cancer Imaging Contrast Agents Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using αvβ 3 Integrin-Targeted Microspheres Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas Factors Associated with Changes in Retinal Layers Following Acute Optic Neuritis: A Longitudinal Study Using Optical Coherence Tomography Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma Historic Effort to 'End Blindness" Marks a Major Milestone with Leading Scientist Recognized for Pioneering Work at VIP Ceremony Featuring Tribute to Ruth Bader Ginsburg Healing and early stent coverage after ultrathin strut biodegradable polymer‐coated sirolimus‐eluting stent implantation: SiBi optical coherence tomography study Influences of hypomagnesemia on optic nerve and retinal vascular structure determined using optical coherence tomography angiography Repeatability and agreement of total corneal and sublayer pachymetry with 2 different algorithms of Fourier-domain optical coherence tomography in myopic and postphotorefractive keratectomy eyes Vessel Density around Foveal Avascular Zone as a Potential Imaging Biomarker for Detecting Preclinical Diabetic Retinopathy: An Optical Coherence Tomography Angiography Study Vascular risk factors for optical coherence tomography-detected macular cysts: The Maastricht Study New severity grading system for Fuchs endothelial corneal dystrophy using anterior segment optical coherence tomography