1. Articles from Eric J. Chaney

    1-24 of 38 1 2 »
    1. Differentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography

      Differentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography

      We report an automated differentiation model for classifying malignant tumor, fibro-adipose, and stroma in human breast tissues based on polarization-sensitive optical coherence tomography (PS-OCT). A total of 720 PS-OCT images from 72 sites of 41 patients with H&E histology-confirmed diagnoses as the gold standard were employed in this study. The differentiation model is trained by the features extracted from both one standard OCT-based metric (i.e., intensity) and four PS-OCT-based metrics (i.e., phase difference between two channels ( PD ), phase retardation ( PR ), local phase retardation ( LPR ), and degree of polarization uniformity ( DOPU )). Further optimized by forward searching and validated ...

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    2. Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography

      Biomechanical sensing of in vivo magnetic nanoparticle hyperthermia-treated melanoma using magnetomotive optical coherence elastography

      Rationale: Magnetic nanoparticle hyperthermia (MH) therapy is capable of thermally damaging tumor cells, yet a biomechanically-sensitive monitoring method for the applied thermal dosage has not been established. Biomechanical changes to tissue are known indicators for tumor diagnosis due to its association with the structural organization and composition of tissues at the cellular and molecular level. Here, by exploiting the theranostic functionality of magnetic nanoparticles (MNPs), we aim to explore the potential of using stiffness-based metrics that reveal the intrinsic biophysical changes of in vivo melanoma tumors after MH therapy. Methods: A total of 14 melanoma-bearing mice were intratumorally injected with ...

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    3. Computational adaptive optics for polarization-sensitive optical coherence tomography

      Computational adaptive optics for polarization-sensitive optical coherence tomography

      Defocus aberration in optical systems, including optical coherence tomography (OCT) systems employing Gaussian illumination, gives rise to the well-known compromise between transverse resolution and depth-of-field. This results in blurry images when out-of-focus, whilst other low-order aberrations (e.g., astigmatism, coma, etc.) present in both the OCT system and biological samples further reduce image resolution and contrast. Computational adaptive optics (CAO) is a computed optical interferometric imaging technique that modifies the phase of the OCT data in the spatial frequency domain to correct optical aberrations and provide improvement of the image quality throughout the three-dimensional (3D) volume. In this Letter, we ...

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    4. Efficacy of endotracheal tube suctioning in intubated intensive care unit patients determined by in vivo catheter-based optical coherence tomography—a pilot study

      Efficacy of endotracheal tube suctioning in intubated intensive care unit patients determined by in vivo catheter-based optical coherence tomography—a pilot study

      Background: Mechanical ventilation using an endotracheal tube (ETT) is one of the critical interventions given to patients in the intensive care unit (ICU). ETTs are associated with the formation of biofilms, placing patients at increased risk for developing ventilator-associated pneumonia (VAP). ETT suctioning is used to remove secretions, reduce bacterial colonization, and reduce the rate of biofilm formation. However, current standard-of-care suctioning procedures do not adequately eliminate all secretions from the ETT. Methods: This observational study was conducted in a cohort of 4 subjects admitted to the ICU and intubated with an ETT, irrespective of ethnicity, gender, or race. A ...

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    5. Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva

      Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva

      Significance: Optical coherence tomography (OCT) offers high spatial resolution and contrast for imaging intraoral structures, yet few studies have investigated its clinical feasibility for dental plaque and gingiva imaging in vivo. Furthermore, the accessibility is often limited to anterior teeth due to bulky imaging systems and probes. Aim: A custom-designed, handheld probe-based, spectral-domain OCT system with an interchangeable attachment was developed to assess dental plaque and gingival health in a clinical setting. Approach: Healthy volunteers and subjects with gingivitis and sufficient plaque were recruited. The handheld OCT system was operated by trained dental hygienists to acquire images of dental plaque ...

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    6. Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence Tomography

      Objectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location of middle ear cavity. The purpose of this study is to correlate WAI measurements with physical characteristics of the middle ear and MEEs determined by optical coherence tomography (OCT), a noninvasive optical imaging technique. Design: Sixteen pediatric subjects (average age of ...

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    7. Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography

      Interstitial magnetic thermotherapy dosimetry based on shear wave magnetomotive optical coherence elastography

      While magnetic thermoseeds are often utilized in interstitial magnetic thermotherapy (iMT) to enable localized tumor ablation, we propose to extend their use as the perturbative source in magnetomotive optical coherence elastography (MM-OCE) so that the heat-induced elasticity alterations can be ‘theranostically’ probed. MM-OCE measurements were found to agree with indentation results. Tissue stiffening was visualized on iMT-treated porcine liver and canine soft tissue sarcoma specimens, where histology confirmed thermal damages. Additionally, the elasticity was found to increase exponentially and linearly with the conventional thermal dosage metrics and the deposited thermal energy, respectively. Collectively, a physiologically-meaningful, MM-OCE-based iMT dosimetry is feasible.

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    8. Intraoperative breast cancer margin detection via polarization-sensitive optical coherence tomography

      Intraoperative breast cancer margin detection via polarization-sensitive optical coherence tomography

      Current standard-of-care for breast conserving surgery (BCS) procedures relies on post-operative histopathology to provide a microscopic view and assessment of surgical margins. To avoid high reoperation rates there has been a great interest in developing new imaging solutions to visualize tissue intraoperatively, and provide real-time feedback on the margin status. Optical coherence tomography (OCT) is a high-resolution label-free, imaging technology that is the optical analogue to ultrasound imaging, except images are based on backscattered near-infrared light. Fundamentally, the contrast mechanism of OCT relies on the light scattering properties associated with different tissue structures. Unlike normal tissue with well-organized tissue structure ...

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    9. Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

      Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

      Objective: A novel hearing-aid scheme using magnetomotive nanoparticles (MNPs) as transducers in the tympanic membrane (TM) is proposed, aiming to noninvasively and directly induce a modulated vibration on the TM. Methods: In this feasibility study, iron-oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles were applied on ex vivo rat TM tissues and allowed to diffuse over ~2 hr. Subsequently, magnetic force was exerted on the MNP-laden TM via a programmable electromagnetic solenoid to induce the magnetomotion. Optical coherence tomography (OCT), along with its phase-sensitive measurement capabilities, was utilized to visualize and quantify the nanometer-scale vibrations generated on the ...

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    10. Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

      Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

      In an institutional review board-approved study, 25 pediatric subjects diagnosed with chronic or recurrent otitis media were observed over a period of six months with optical coherence tomography (OCT). Subjects were followed throughout their treatment at the initial patient evaluation and preoperative consultation, surgery (intraoperative imaging), and postoperative follow-up, followed by an additional six months of records-based observation. At each time point, the tympanic membrane (at the light reflex region) and directly adjacent middle-ear cavity were observed in vivo with a handheld OCT probe and portable system. Imaging results were compared with clinical outcomes to correlate the clearance of symptoms ...

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    11. Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy

      Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy

      Impaired skin wound healing is a significant co-morbid condition of diabetes that is caused by poor microcirculation, among other factors. Studies have shown that angiogenesis, a critical step in the wound healing process in diabetic wounds, can be promoted under hypoxia. In this study, an angiogenesis-promoting topical treatment for diabetic wounds, which promotes angiogenesis by mimicking a hypoxic environment via inhibition of prolyl hydroxylase resulting in elevation or maintenance of hypoxia inducible factor (HIF), was investigated utilizing a custom-built multimodal microscopy system equipped with phase-variance optical coherence tomography (PV-OCT) and fluorescence lifetime imaging microscopy (FLIM). PV-OCT was used to track ...

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    12. Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Background and Objective Sarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from muscle and adipose tissue. Study Design and Methods In this study, tumor margin delineation in 19 feline and canine veterinary patients was achieved with intraoperative OCT to help validate tumor ...

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    13. Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

      Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

      Background Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of macrometastasis , the majority of the resected lymph nodes are histologically negative. Improvements need to be made to better detect micrometastasis , minimize or eliminate lymphatic disruption complications, and provide immediate and accurate intraoperative feedback for in vivo cancer staging to better guide surgery. Methods We evaluated the use of optical coherence tomography (OCT), a high-resolution ...

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    14. Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains a significant challenge, resulting in surgical reinterventions to achieve adequate local control. Currently, no label-free imaging method is available for surgeons to examine the resection bed in vivo for microscopic residual cancer. Optical coherence tomography (OCT) enables real-time high-resolution imaging of tissue microstructure. Previous studies have demonstrated that OCT analysis of excised tissue specimens can distinguish between normal and cancerous tissues by identifying the heterogeneous and disorganized microscopic tissue structures indicative ...

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    15. Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

      Representative magnetomotive signal (green) using targeted and non-targeted magnetomotive microspheres in atherosclerotic diseased rabbit aortas. We report the development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV-MM-OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a ...

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    16. Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment

      Feature Of The Week 10/12/14: University of Illinois at Urbana-Champaign Investigates PS-OCT with Ultimate Aim of Intraoperative Breast Cancer Tumor Margin Assessment

      Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility ...

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    17. Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

      Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

      Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility ...

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    18. Comparison of a MEMS-Based Handheld OCT Scanner With a Commercial Desktop OCT System for Retinal Evaluation

      Comparison of a MEMS-Based Handheld OCT Scanner With a Commercial Desktop OCT System for Retinal Evaluation

      Purpose: The goal of this study was to evaluate the ability of our handheld optical coherence tomography (OCT) scanner to image the posterior and anterior structures of the human eye, and especially the individual layers of the retina, and to compare its diagnostic performance with that of a fixed desktop commercial ophthalmic OCT system. Methods: We compared the clinical imaging results of our handheld OCT with a leading commercial desktop ophthalmic system (RTVue) used in specialist offices. Six patients exhibiting diabetes-related retinal pathology had both eyes imaged with each OCT system. Results: In both sets of images, the structural irregularities ...

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    19. Segmentation And Correlation Of Optical Coherence Tomography And X-RAY Images For Breast Cancer Diagnostics.

      Segmentation And Correlation Of Optical Coherence Tomography And X-RAY Images For Breast Cancer Diagnostics.

      Pre-operative X-ray mammography and intraoperative X-ray specimen radiography are routinely used to identify breast cancer pathology. Recent advances in optical coherence tomography (OCT) have enabled its use for the intraoperative assessment of surgical margins during breast cancer surgery. While each modality offers distinct contrast of normal and pathological features, there is an essential need to correlate image -based features between the two modalities to take advantage of the diagnostic capabilities of each technique. We compare OCT to X-ray images of resected human breast tissue and correlate different tissue features between modalities for future use in real-time intraoperative OCT imaging . X-ray ...

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    20. Long-term time-lapse multimodal intravital imaging of regeneration and bone-marrow-derived cell dynamics in skin (World Scientific)

      Long-term time-lapse multimodal intravital imaging of regeneration and bone-marrow-derived cell dynamics in skin (World Scientific)

      A major challenge for translating cell-based therapies is understanding the dynamics of cells and cell populations in complex in vivo environments. Intravital microscopy has shown great promise for directly visualizing cell behavior in vivo. However, current methods are limited to relatively short imaging times (hours), by ways to track cell and cell population dynamics over extended time-lapse periods (days to weeks to months), and by relatively few imaging contrast mechanisms that persist over extended investigations. We present technology to visualize and quantify complex, multifaceted dynamic changes in natural deformable skin over long time periods using novel multimodal imaging and a ...

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    21. Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using αvβ 3 Integrin-Targeted Microspheres

      Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using αvβ 3 Integrin-Targeted Microspheres

      Purpose We investigated the early-stage fatty streaks/plaques detection using magnetomotive optical coherence tomography (MM-OCT) in conjunction with α v β 3 integrin-targeted magnetic microspheres (MSs). The targeting of functionalized MSs was investigated by perfusing ex vivo aortas from an atherosclerotic rabbit model in a custom-designed flow chamber at physiologically relevant pulsatile flow rates and pressures. Procedures Aortas were extracted and placed in a flow chamber. Magnetic MS contrast agents were perfused through the aortas and MM-OCT, fluorescence confocal, and bright field microscopy were performed on the ex vivo aorta specimens for localizing the MSs. Results The results showed a statistically significant ...

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    22. Three-dimensional Optical Coherence Tomography for Optical Biopsy of Lymph Nodes and Assessment of Metastatic Disease

      Three-dimensional Optical Coherence Tomography for Optical Biopsy of Lymph Nodes and Assessment of Metastatic Disease

      Background Numerous techniques have been developed for localizing lymph nodes before surgical resection and for their histological assessment. Nondestructive high-resolution transcapsule optical imaging of lymph nodes offers the potential for in situ assessment of metastatic involvement, potentially during surgical procedures. Methods Three-dimensional optical coherence tomography (3-D OCT) was used for imaging and assessing resected popliteal lymph nodes from a preclinical rat metastatic tumor model over a 9-day time-course study after tumor induction. The spectral-domain OCT system utilized a center wavelength of 800 nm, provided axial and transverse resolutions of 3 and 12 μm, respectively, and performed imaging at 10,000 ...

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    23. Noninvasive in vivo optical detection of biofilm in the human middle ear

      Noninvasive in vivo optical detection of biofilm in the human middle ear

      Otitis media (OM), a middle-ear infection, is the most common childhood illness treated by pediatricians. If inadequately treated, OM can result in long-term chronic problems persisting into adulthood. Children with chronic OM or recurrent OM often have conductive hearing loss and communication difficulties and require surgical treatment. Tympanostomy tube insertion, the placement of a small drainage tube in the tympanic membrane (TM), is the most common surgical procedure performed in children under general anesthesia. Recent clinical studies have shown evidence of a direct correspondence between chronic OM and the presence of a bacterial biofilm within the middle ear. Biofilms are ...

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    24. Real-time three-dimensional optical coherence tomography image-guided core-needle biopsy system

      Real-time three-dimensional optical coherence tomography image-guided core-needle biopsy system

      Advances in optical imaging modalities, such as optical coherence tomography (OCT), enable us to observe tissue microstructure at high resolution and in real time. Currently, core-needle biopsies are guided by external imaging modalities such as ultrasound imaging and x-ray computed tomography (CT) for breast and lung masses, respectively. These image-guided procedures are frequently limited by spatial resolution when using ultrasound imaging, or by temporal resolution (rapid real-time feedback capabilities) when using x-ray CT. One feasible approach is to perform OCT within small gauge needles to optically image tissue microstructure. However, to date, no system or core-needle device has been developed ...

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    1-24 of 38 1 2 »
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    Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence Tomography Optical Coherence Tomography: The Intraoperative Assessment of Lymph Nodes in Breast Cancer In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes Non-invasive optical interferometry for the assessment of biofilm growth in the middle ear Handheld Optical Coherence Tomography Scanner for Primary Care Diagnostics Targeted Multifunctional Multimodal Protein-Shell Microspheres as Cancer Imaging Contrast Agents Noninvasive in vivo optical detection of biofilm in the human middle ear Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery Interpretation of anatomic correlates of outer retinal bands in optical coherence tomography Optical Coherence Tomography Angiography Findings of Iris Ischemia and Reperfusion in Cytomegalovirus Panuveitis Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility