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Articles from V. A. Kamensky

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  1. Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor

    Explore Article SPIE Digital Library (Feb 16 2010) Oncology , Urology

    Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 109 particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When the accumulation of nanoparticles in the tumor was maximal, hyperthermia was accomplished using the LSP-AZOR laser setup generating cw radiation at 810 nm. The duration of exposition was 20 min. The therapeutical ... (Read Full Article)

    Comment on Article Mentions:   Nizhny Novgorod State Medical Academy   Vladislav A. Kamensky   Russian Academy of Sciences

  2. Mechanical compression for biotissue image enhancement in optical coherence tomography

    Explore Article SPIE Digital Library (Feb 11 2010)

    Mechanical compression for biotissue image enhancement in optical coherence tomography The paper discusses application of mechanical compression for contrasting structural components of biotissues with different mechanical properties in optical coherence tomography (OCT) images. Ex vivo study on human rectum samples and in vivo study on human thin skin samples are performed. It is shown that for ex vivo sample the contrast between epithelial and stroma layers increases with increase in applied pressure. For in vivo sample it is shown that at weak constant applied pressure the contrast between epidermal and dermal layer increases exhibiting maximum after 2-3 minutes since pressure application. Monte Carlo simulations of OCT images of human rectum ... (Read Full Article)

    Comment on Article Mentions:   Nizhny Novgorod State Medical Academy   Russian Academy of Sciences   Alexander I. Abelevich

  3. Compression as a method for increasing the informativity of optical coherence tomography of biotissues

    Explore Article SpringerLink Home (Dec 24 2009)

    The efficiency of the mechanical compression of biotissues for improving the differentiation between pathological changes in the structure of a biotissue observed by the method of optical coherence tomography (OCT) is investigated. The effect of the compression in the OCT-images of samples of the human rectum affected by inflammation and carcinoma is studied ex vivo. It is shown that the use of compression makes it possible to differentiate between these pathological changes. To interpret experimental data, images of an inflamed part of rectum are modeled by the Monte Carlo method for different degrees of compression. The results of modeling agree ... (Read Full Article)

    Comment on Article Mentions:   Russian Academy of Sciences   Nizhny Novgorod State Medical Academy   Elena V. Zagaynova

  4. Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo

    Explore Article SPIE Digital Library (Feb 16 2009) Dermatology

    Dynamics of nanoparticles penetrating and accumulating in healthy (skin) and pathologically altered (tumor) tissue was investigated in vivo by the method of optical coherence tomography (OCT). Gold nanoshells having the size of 130/15 nm and titanium dioxide nanoparticles 40-100 nm in size were stud ... [Proc. SPIE 7188, 71880L (2009)] published Mon Feb 16, 2009. (Read Full Article)

    Comment on Article Mentions:   Nizhny Novgorod State Medical Academy   Elena V. Zagaynova   Pavel D. Agrba

  5. Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation

    Explore Article Institute of Physics (Aug 17 2008)

    Abstract. The possibility of using silica–gold nanoshells with 150 nm silica core size and 25 nm thick gold shell as contrasting agents for optical coherence tomography (OCT) is analyzed. Experiments on agar biotissue phantoms showed that the penetration of nanoshells into the phantoms increases the intensity of the optical coherence tomography (OCT) signal and the brightness of the corresponding areas of the OCT image. In vivo experiments on rabbit skin demonstrated that the application of nanoshells onto the skin provides significant contrasting of the borders between the areas containing nanoshells and those without. This effect of nanoshells on skin in ... (Read Full Article)

    Comment on Article Mentions:   University of Oulu   Nizhny Novgorod State Medical Academy   Elena V. Zagaynova

  6. Gold nanoshells for OCT imaging contrast: From model to in-vivo study

    Explore Article SPIE Digital Library (Feb 13 2008) Dermatology

    E. V. Zagainova, M. V. Shirmanova, A. G. Orlova et al. We have investigated the effect of application of gold nanoshells with a 150 nm silica core size and 25 nm thick gold coating on optical properties of skin. We have analyzed the possibility of using these particles as a contrasting agent for optical coherence tomography (OCT). A set of Monte Carlo c ... [Proc. SPIE Int. Soc. Opt. Eng. 6865, 68650K (2008)] published Wed Feb 13, 2008. (Read Full Article)

    Comment on Article Mentions:   Nizhny Novgorod State Medical Academy   Moscow State University   Mikhail Y. Kirillin

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