1. Articles from M. V. Shirmanova

    1-6 of 6
    1. Laser hyperthermia of tumors using gold nanoparticles monitored by optical coherence tomography and acoustic thermometry

      Laser hyperthermia of tumors using gold nanoparticles monitored by optical coherence tomography and acoustic thermometry

      Local laser hyperthermia of grafted RShM-5 tumors in mice with the use of plasmon resonant gold nanoparticles has been carried out. Accumulation of particles in the tumor was monitored in vivo noninvasively by optical coherence tomography. Thereby it was determined that the maximal content of nanoparticles in the tumor was reached within 5 h after intravenous administration, and laser hyperthermia was performed at this time. Monitoring the tumor temperature during the treatment by IR thermography and acoustic thermometry showed that the nanoparticles provided efficient temperature elevation inside the tumor as well as more selective heating. Local laser hyperthermia with gold ...

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    2. Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues

      Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues
      In this study, dynamics of nanoparticles penetrating and accumulating in biotissue (healthy skin) was investigated in vivo by the noninvasive method of optical coherence tomography (OCT). Gold nanoshells and titanium dioxide nanoparticles were studied. The processes of the nanoparticles penetration and accumulation in biotissue are accompanied by the changes in optical properties of skin which affect the OCT images. The continuous OCT monitoring of the process of the nanoparticles penetration into skin showed that these changes appeared in 30 min after application of nanoparticles on the surface; the time of accumulation of maximal nanoparticles concentration in skin was observed in ...
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    3. Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor

      Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor
      The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 109 particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When the accumulation of nanoparticles in the tumor was maximal, hyperthermia was accomplished using the LSP-AZOR laser setup generating cw radiation at 810 nm. The duration of exposition was 20 min ...
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    4. Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo

      Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo
      Dynamics of nanoparticles penetrating and accumulating in healthy (skin) and pathologically altered (tumor) tissue was investigated in vivo by the method of optical coherence tomography (OCT). Gold nanoshells having the size of 130/15 nm and titanium dioxide nanoparticles 40-100 nm in size were stud ... [Proc. SPIE 7188, 71880L (2009)] published Mon Feb 16, 2009.
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    5. Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation

      Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation
      Abstract. The possibility of using silica–gold nanoshells with 150 nm silica core size and 25 nm thick gold shell as contrasting agents for optical coherence tomography (OCT) is analyzed. Experiments on agar biotissue phantoms showed that the penetration of nanoshells into the phantoms increases the intensity of the optical coherence tomography (OCT) signal and the brightness of the corresponding areas of the OCT image. In vivo experiments on rabbit skin demonstrated that the application of nanoshells onto the skin provides significant contrasting of the borders between the areas containing nanoshells and those without. This effect of nanoshells on skin ...
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    6. Gold nanoshells for OCT imaging contrast: From model to in-vivo study

      E. V. Zagainova, M. V. Shirmanova, A. G. Orlova et al. We have investigated the effect of application of gold nanoshells with a 150 nm silica core size and 25 nm thick gold coating on optical properties of skin. We have analyzed the possibility of using these particles as a contrasting agent for optical coherence tomography (OCT). A set of Monte Carlo c ... [Proc. SPIE Int. Soc. Opt. Eng. 6865, 68650K (2008)] published Wed Feb 13, 2008.
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    1-6 of 6
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  2. Topics in the News

    1. (6 articles) Institute of Applied Physics
    2. (6 articles) Nizhny Novgorod State Medical Academy
    3. (6 articles) Elena V. Zagaynova
    4. (5 articles) Vladislav A. Kamensky
    5. (4 articles) Mikhail Y. Kirillin
    6. (4 articles) Pavel D. Agrba
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    Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues Laser hyperthermia of tumors using gold nanoparticles monitored by optical coherence tomography and acoustic thermometry Optical coherence tomography in an eyelid lesion due to Molluscum contagiosum Lung adenocarcinoma choroidal metastasis studied by optical coherence tomography angiography Early detection of enamel demineralization by optical coherence tomography Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification AS-OCT Guided Treatment Of Diffuse Conjunctival Squamous Cell Carcinoma With Resection ... The Eyes Behind Surgical Robots Ophthalmology/Functional Imaging: OCT + AO for functional imaging