1. Articles from Melissa M. Eberle

    1-4 of 4
    1. Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography

      Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography

      Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images. In this study, OCT was used to detect changes in the optical properties of cortical tissue in vivo in mice during the induction of global (pentylenetetrazol) and focal (4-aminopyridine) seizures. Through the use of a confidence interval statistical method on depth-resolved volumes of attenuation coefficient, we demonstrated localization of regions exhibiting both significant positive and negative changes in attenuation coefficient, as well as differentiating between global and focal seizure propagation.

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    2. Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography

      Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography

      Cerebral edema develops in response to a variety of conditions, including traumatic brain injury and stroke, and contributes to the poor prognosis associated with these injuries. This study examines the use of optical coherence tomography (OCT) for detecting cerebral edema in vivo . Three-dimensional imaging of an in vivo water intoxication model in mice was performed using a spectral-domain OCT system centered at 1300 nm. The change in attenuation coefficient was calculated and cerebral blood flow was analyzed using Doppler OCT techniques. We found that the average attenuation coefficient in the cerebral cortex decreased over time as edema progressed. The initial ...

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    3. OCT News 2013 Student Paper Awarded to Carissa Reynolds from University of California Riverside

      OCT News 2013 Student Paper Awarded to Carissa Reynolds from University of California Riverside

      Carissa Reynolds from University of California Riverside was a winner of the 2013 OCT News Student paper award for her submission “Using Optical Coherence Tomography to Detect Cerebral Edema.” Below is a summary of her work: Cerebral edema, an increase in brain water content, is responsible for significant morbidity and mortality among patients suffering from neurological disorders such as traumatic brain injury, stroke, brain tumor and infection. Cerebral edema develops in response to these conditions and leads to further clinical deterioration by, for example, raising the intracranial pressure (ICP), disrupting blood flow to the brain and/or causing brain herniation ...

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    4. In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography

      In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
      The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical changes, specifically changes in near-infrared optical scattering, may precede EEG seizure onset in in vivo models. Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth resolved cross-sectional images. In this study, OCT was used to detect changes in optical properties of cortical tissue in vivo in mice before and during the induction ...
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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) UC Riverside
    2. (4 articles) B. Hyle Park
    3. (3 articles) Yan Wang
    4. (2 articles) Carissa L. Reynolds
    5. (1 articles) Harvard University
    6. (1 articles) Massachusetts General Hospital
    7. (1 articles) M. Shahidul Islam
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    In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography OCT News 2013 Student Paper Awarded to Carissa Reynolds from University of California Riverside Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography Localization of cortical tissue optical changes during seizure activity in vivo with optical coherence tomography Perimeter Medical Imaging Closes Oversubscribed $C4.4M Financing Time-domain optical coherence tomography system based on moving-optical-wedge interferometer ML and AI: At the Forefront of Ophthalmology Automated 3D Optical Coherence Tomography to Elucidate Biofilm Morphogenesis Over Large ... IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION Optical coherence refraction tomography University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity