1. Articles from Roy G. Geronemus

    1-7 of 7
    1. Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery

      Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery

      Background: Topical medications play a large role in the management of cutaneous diseases, but penetration is limited. Device-assisted drug delivery using mechanical destruction, lasers, and other energy-based modalities can increase penetration and absorption through creation of transcutaneous channels. Objective: To examine real-time, in vivo cutaneous changes in response to various devices used to improve topical drug delivery through optical coherence tomography (OCT) imaging. Methods and materials: Treatment was performed with 8 medical devices, including mechanical destruction, lasers, and other energy-based modalities. Optical coherence tomography was used for real-time, noninvasive, in vivo imaging. Results: Using OCT, microneedling and radiofrequency microneedling demonstrated ...

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      Mentions: UC Irvine
    2. Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping

      Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping

      Introduction: Port-wine birthmarks (PWBs) are congenital capillary malformations that can be located on any area of the body. Vascular features include vessel size, depth, and density, which can greatly differ between patients, individual lesions, and even sites within the same lesion. Previous studies have determined that the location of PWB lesions has impacted their clinical response to laser treatment. Objective: We utilized dynamic optical coherence tomography (D-OCT) to measure in vivo vessel diameter, density, and superficial plexus depth in patients of all ages with PWB on various sites of the body. We hypothesized that these vascular characteristics would differ according ...

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    3. Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Background: Port wine birthmarks (PWB) are congenital capillary malformations. Vessel characteristics, such as diameter and depth, may impact presentation and outcomes. They can be imaged using dynamic optical coherence tomography (D-OCT), a high-resolution, non-invasive imaging method. Purpose: We conducted a cross-sectional observational study to measure in-vivo vascular characteristics as a function of PWB color. Methods: Patients undergoing treatment for PWB were recruited from three sites. PWB were classified by color, and D-OCT images with calculations were obtained. Results: 108 patients were enrolled. Mean age correlated with PWB color, with younger patients having lighter and older patients having darker birthmarks (p ...

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    4. Dynamic Optical Coherence Tomography of Cutaneous Blood Vessels in Melasma and Vessel Response to Oral Tranexamic Acid

      Dynamic Optical Coherence Tomography of Cutaneous Blood Vessels in Melasma and Vessel Response to Oral Tranexamic Acid

      Background and objectives: Melasma may be related to aberrant blood vessels, but there has been no report on the utility of dynamic optical coherence tomography (D-OCT) in studying vessel characteristics in melasma. We studied the characteristics of cutaneous blood vessels in melasma and the effects of oral tranexamic acid (TXA) with D-OCT. Study design/materials and methods: Six patients with moderate to severe melasma had a D-OCT scanning of the areas on the face affected by melasma and not affected by it. Three of them had scans within 3 months after starting oral TXA and at a follow-up visit. Blood ...

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    5. Topical perfluorodecalin resolves immediate whitening reactions and allows rapid effective multiple pass treatment of tattoos

      Topical perfluorodecalin resolves immediate whitening reactions and allows rapid effective multiple pass treatment of tattoos

      Background and Objective Laser tattoo removal using multiple passes per session, with each pass delivered after spontaneous resolution of whitening, improves tattoo fading in a 60-minute treatment time. Our objective was to evaluate the safety and efficacy of topical perfluorodecalin (PFD) in facilitating rapid effective multiple-pass tattoo removal. Study Design In a randomized, controlled study using Q-switched ruby or Nd:YAG laser, 22 previously treated tattoos were treated with 3 passes using PFD to resolve whitening after each pass (“R0 method”). In previously untreated symmetric tattoos, seven were treated over half of the tattoo with the R20 method, and the ...

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    1-7 of 7
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    1. (4 articles) Michelson Diagnostics
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    Topical perfluorodecalin resolves immediate whitening reactions and allows rapid effective multiple pass treatment of tattoos Successful Utilization of Optical Coherence Tomography as a Non-Invasive, Bedside Imaging Technique To Identify Residual Nodular Basal Cell Carcinoma at Well-Healed and Clinically Unidentifiable Biopsy Site Treating port wine stain birthmarks using dynamic optical coherence tomography-guided setting Dynamic Optical Coherence Tomography of Cutaneous Blood Vessels in Melasma and Vessel Response to Oral Tranexamic Acid Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography Analysis of port-wine birthmark vascular characteristics by location: Utility of optical coherence tomography mapping Evaluation of Device-Based Cutaneous Channels Using Optical Coherence Tomography: Impact for Topical Drug Delivery Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy Thickness of retinal pigment epithelium–Bruch’s membrane complex in adult Chinese using optical coherence tomography Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography