1. Articles from Nan-Shan Zhong

    1-10 of 10
    1. Evaluation of the normal airway morphology using optical coherence tomography

      Evaluation of the normal airway morphology using optical coherence tomography

      Background The anatomical location of small airways, the distribution of airway cartilage and their correlation with ageing have not been well elucidated. Objective To explore the morphological characteristics of small airways in vivo , and how airway structural changes correlate with age using endobronchial optical coherence tomography (EB-OCT). Methods We recruited 112 subjects with peripheral pulmonary nodules. Participants underwent computed tomography, spirometry, and EB-OCT measurements. We measured the airway internal diamaeter (D mean ), inner area (Ai), airway wall area percentage (Aw%) and the thickness of airway cartilage. EB-OCT airway structural characteristics at different age intervals were analyzed, and the association between ...

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    2. Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD

      Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD

      Background: Spirometry confers limited value for identifying small-airway disorders (SADs) in early-stage COPD, which can be detected with impulse oscillometry (IOS) and endobronchial optical coherence tomography (EB-OCT). Whether IOS is useful for reflecting small-airway morphological abnormalities in COPD remains unclear. Objectives: To compare the diagnostic value of spirometry and IOS for identifying SADs in heavy-smokers and COPD based on the objective assessment with EB-OCT. Methods: We recruited 59 COPD patients (stage I, n=17; stage II, n=18; stage III–IV, n=24), 26 heavy-smokers and 21 never-smokers. Assessments of clinical characteristics, spirometry, IOS and EB-OCT were performed. Receiver operation ...

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    3. Clinical study of optical coherence tomography in the diagnosis of peripheral pulmonary artery thrombus

      Clinical study of optical coherence tomography in the diagnosis of peripheral pulmonary artery thrombus

      Background Peripheral pulmonary artery thrombus (PPT) is common in the clinic. However, due to the lack of an ideal diagnostic tool, PPT cannot be quickly diagnosed and effectively treated at present. Optical coherence tomography (OCT) is a new intravascular imaging technique that is characterized by high image resolution. This technique is suitable for small vessel imaging and has the ability to distinguish red and white thrombi. Objective This study aimed to evaluate the value of OCT in the diagnosis of PPT and in identifying the nature of thrombi by comparing the difference in sensitivity between OCT and selective pulmonary angiography ...

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    4. Optical coherence tomography in imaging of peripheral pulmonary arteries

      Optical coherence tomography in imaging of peripheral pulmonary arteries

      Background: To establish an optical coherence tomography (OCT)-based method for imaging peripheral pulmonary arteries. Methods: We recruited eight patients (five men; average age, 48±12 years; peripheral pulmonary artery thrombosis, three patients; idiopathic pulmonary hypertension, three patients; interstitial lung disease, two patients) who underwent OCT of the peripheral pulmonary arteries in the First Affiliated Hospital of Guangzhou Medical University and Guangzhou Institute of Respiratory Diseases, between September 2009 and September 2010. OCT was performed using both the conventional OCT imaging method (COI) and the improved pulmonary artery imaging method (IPI). In the IPI, contrast agent was used as an ...

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    5. Measuring Airway Remodeling in Patients with Different COPD Staging Using Endobronchial Optical Coherence Tomography

      Measuring Airway Remodeling in Patients with Different COPD Staging Using Endobronchial Optical Coherence Tomography

      Background Although forced expiratory volume in one second (FEV 1 ) remains the gold standard for staging COPD, the association between airway remodeling and airflow limitation remains unclear. Objective Endobronchial optical coherence tomography (EB-OCT) was performed to assess the association between disorders of large- and medium-to-small-sized airways and COPD staging. We also evaluated small-airway architecture in heavy-smokers with normal FEV 1 (S NL ) and healthy never-smokers. Methods We recruited 48 COPD patients (stage Ⅰ, n=14; stage Ⅱ, n=15; stage Ⅲ-Ⅳ, n=19), 21 S NL , and 17 healthy never-smokers. Smoking history inquiry, spirometry, chest computed tomography, bronchoscopy and EB-OCT ...

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    6. Validation of human small-airway measurements using endobronchial optical coherence tomography: an observational study

      Validation of human small-airway measurements using endobronchial optical coherence tomography: an observational study

      Background Small-airway remodelling is the cardinal pathological feature underlying chronic obstructive pulmonary disease (COPD). Identification of early-stage pathological changes is crucial for the diagnosis, treatment, and prognosis of respiratory diseases. Our study aimed to investigate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessment of small-airways morphology in patients with pulmonary nodules who were scheduled for lung resection surgery (four had COPD, four were smokers with normal lung function, and four were life-long non-smokers). Patients with respiratory diseases other than COPD were excluded. Methods 12 patients with pulmonary nodules scheduled for lung resection underwent spirometry, multidetector CT (MDCT), and ...

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    7. Validation of human small airway measurements using endobronchial optical coherence tomography

      Validation of human small airway measurements using endobronchial optical coherence tomography

      Background Small airway remodeling is the cardinal feature underlying chronic airway diseases. There is no modality which identifies small airway pathological changes, which is crucial for early diagnosis, efficacy and prognostic assessment. Objective To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo . Methods Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multi-detector computed tomography (MDCT) and EB-OCT. We measured D mean (mean luminal diameter), Ai (inner luminal area), Aw (airway wall area) and Aw% [Aw/(Ai + Aw) × 100%] from the 3rd to 5th generation bronchi of RB9 segment by ...

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    8. Visualization of Peripheral Pulmonary Artery Red Thrombi Utilizing Optical Coherence Tomography

      Visualization of Peripheral Pulmonary Artery Red Thrombi Utilizing Optical Coherence Tomography

      Optical coherence tomography (OCT) is a new imaging technique capable of obtaining high-resolution intravascular images and has been used in interventional cardiology. However, an application of OCT in pulmonary arteries had seldom been documented. In this case, OCT imaging is performed in peripheral pulmonary arteries and shows mural red thrombi. Subsequently, the red thrombi are aspirated and confirmed by a histological examination. These findings suggest that OCT may be a useful tool to depict peripheral pulmonary artery thrombi.

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      Mentions: Abbott
    9. Using optical coherence tomography to detect peripheral pulmonary thrombi

      Using optical coherence tomography to detect peripheral pulmonary thrombi

      Background Optical coherence tomography (OCT) is a new imaging technique capable of obtaining high-resolution intravascular images of small vessels and has been widely used in interventional cardiology. However, application of OCT in peripheral pulmonary arteries in patients has been seldom documented. Methods Three patients who were highly suspected peripheral pulmonary arteries thrombi and had undergone CT pulmonary angiography but tested negative for thrombi in peripheral pulmonary arteries were enrolled. Subsequently, OCT imaging was performed in peripheral pulmonary arteries. The patients received more than three-month anticoagulative treatment if thrombi were detected by OCT. Thereafter, OCT re-evaluation of the thrombolized blood vessels ...

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      Mentions: Abbott
    1-10 of 10
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    Using optical coherence tomography to detect peripheral pulmonary thrombi Visualization of Peripheral Pulmonary Artery Red Thrombi Utilizing Optical Coherence Tomography Validation of human small airway measurements using endobronchial optical coherence tomography Validation of human small-airway measurements using endobronchial optical coherence tomography: an observational study Measuring Airway Remodeling in Patients with Different COPD Staging Using Endobronchial Optical Coherence Tomography Optical coherence tomography in imaging of peripheral pulmonary arteries Clinical study of optical coherence tomography in the diagnosis of peripheral pulmonary artery thrombus Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD Evaluation of the normal airway morphology using optical coherence tomography Airway remodeling and bronchodilator responses in asthma assessed by endobronchial optical coherence tomography Association of retinal thickness and microvasculature with cognitive performance and brain volumes in elderly adults A Deep Learning Framework for the Detection and Quantification of Reticular Pseudodrusen and Drusen on Optical Coherence Tomography