1. Articles from Tsung-Hsun Hsieh

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    1. Feature Of The Week 10/21/12: Cell Death Detection by Quantitative Three-Dimensional Single-Cell Tomography

      Explore Optical Coherence Tomography News Oncology , Broadband Sources
      Feature Of The Week 10/21/12: Cell Death Detection by Quantitative Three-Dimensional Single-Cell Tomography


      The aim of cancer therapies is mainly to stop cell proliferation or induce cell death. Cell death regulation is important for normal development and homeostasis. Cancer cells escape from death signals and continue their abnormal proliferation. Therefore, the ability to induce death in cancer cells has been a crucial biomarker for the efficacy of chemotherapeutic agents. However, individual cancer cells, even from the same population, vary greatly in their response to cell death stimuli. Measuring the response at the single-cell levels provide further pharmacokinetic and pharmacodynamics information, which aids drug development and regimen design. Developing a microscopic technology with non-invasive ...

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      Mentions: National Taiwan University

    2. Cell death detection by quantitative three-dimensional single-cell tomography

      Explore opticsinfobase.org
      Cell death detection by quantitative three-dimensional single-cell tomography

      Ultrahigh-resolution optical coherence tomography (UR-OCT) has been used for the first time to our knowledge to study single-cell basal cell carcinoma (BCC) in vitro. This noninvasive, in situ, label-free technique with deep imaging depth enables three-dimensional analysis of scattering properties of single cells with cellular spatial resolution. From three-dimensional UR-OCT imaging, live and dead BCC cells can be easily identified based on morphological observation. We developed a novel method to automatically extract characteristic parameters of a single cell from data volume, and quantitative comparison and parametric analysis were performed. The results demonstrate the capability of UR-OCT to detect cell death ...

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      Mentions: National Taiwan University
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