1. Articles from Justin E. Davies

    1-8 of 8
    1. Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

      Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs

      Background— Although disturbed flow is thought to play a central role in the development of advanced coronary atherosclerotic plaques, no causal relationship has been established. We evaluated whether inducing disturbed flow would cause the development of advanced coronary plaques, including thin cap fibroatheroma. Methods and Results— D374Y -PCSK9 hypercholesterolemic minipigs (n=5) were instrumented with an intracoronary shear-modifying stent (SMS). Frequency-domain optical coherence tomography was obtained at baseline, immediately poststent, 19 weeks, and 34 weeks, and used to compute shear stress metrics of disturbed flow. At 34 weeks, plaque type was assessed within serially collected histological sections and coregistered to ...

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    2. First Optical Coherence Tomography Follow-up of Coronary Bifurcation Lesions Treated by Drug-Eluting Balloons

      First Optical Coherence Tomography Follow-up of Coronary Bifurcation Lesions Treated by Drug-Eluting Balloons

      Background. A strategy of percutaneous bifurcation intervention with provisional bare-metal stent (BMS) implantation followed by drug-eluting balloon (DEB) treatment represents a valuable opportunity in patients not compliant with long-duration dual-antiplatelet therapy. We used optical coherence tomography (OCT) to assess coronary bifurcation lesions treated by BMS and DEB, and secondarily, to better explore the association between stent geometry and tissue coverage. Methods. Twelve patients underwent frequency-domain OCT 6 months after undergoing percutaneous bifurcation intervention with BMS implantation followed by kissing DEB. The same type of BMS was correspondingly implanted in silicone bifurcation models and scanned by microcomputed tomography. Results. Overall, a ...

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    3. Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition

      Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition

      BACKGROUND: Lack of re-endothelialization and neointimal coverage on stent struts has been put forward as the main underlying mechanism leading to late stent thrombosis. Incomplete stent apposition (ISA) has been observed frequently in patients with very late stent thrombosis after drug eluting stent implantation, suggesting a role of ISA in the pathogenesis of this adverse event. The aim of this study was to evaluate the impact of different degrees of ISA severity on abnormal shear rate and healing response with coverage, because of its potential implications for stent optimization in clinical practice. METHODS AND RESULTS: We characterized flow profile and ...

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    4. Bioabsorbable scaffold optimization in provisional stenting: insight from optical coherence tomography

      Bioabsorbable scaffold optimization in provisional stenting: insight from optical coherence tomography

      Since the emergence of biabsorbable vascular scaffolds (BVS), treatment of bifurcation lesions with these devices has remained a source of question. Although SB dilatation has been previously performed with BVS, it is not yet clear how dilatation across BVS strut may impact scaffold structure. A 74-year-old lady with hypercholesterolaemia and …

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    5. Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases

      Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases

      Purpose To allow an accurate diagnosis of coronary artery diseases by enhancing optical coherence tomography (OCT) images of atheromatous plaques using a novel automated attenuation compensation technique. Background One of the major drawbacks of coronary OCT imaging is the rapid attenuation of the OCT signal, limiting penetration in tissue to only few millimetres. Visualisation of deeper anatomy is however critical for accurate assessment of plaque burden in-vivo. Methods A compensation algorithm, previously developed to correct for light attenuation in soft tissues and to enhance contrast in ophthalmic OCT images, was applied to intracoronary plaque imaging using spectral-domain OCT. Results Application ...

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    6. Feature Of The Week 9/9/12: Imaging of Coronary Artery Plaques Using Contrast Enhanced Optical Coherence Tomography

      Feature Of The Week 9/9/12: Imaging of Coronary Artery Plaques Using Contrast Enhanced Optical Coherence Tomography

      Optical Coherence Tomography (OCT) has recently emerged as a promising technology for intravascular guidance of interventions. With a resolution on the order of 10 microns, Intravascular OCT surpasses Intravascular Ultrasounds, and allows for precise measurement of cap thickness and identification of lipid rich Thin-Cap Fibroatheroma (TCFA). The diagnostic accuracy and assessment of atherosclerotic plaque morphology with OCT remains however limited by the rapid attenuation of OCT signal in tissue, limiting contrast on deep plaque structure and accurate assessment of plaque burden.A contrast enhancement algorithm, previously developed to compensate for light attenuation in spectral-domain OCT images of the human optic ...

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    7. Imaging of coronary artery plaques using contrast-enhanced optical coherence tomography

      Imaging of coronary artery plaques using contrast-enhanced optical coherence tomography

      Optical coherence tomography (OCT) has recently emerged as a promising technology for intravascular guidance of interventions. With a resolution on the order of 10µm, intravascular OCT surpasses intravascular ultrasounds, and allows for precise measurement of cap thickness and identification of lipid-rich thin-cap fibroatheroma. The diagnostic accuracy and assessment of atherosclerotic plaque

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    1-8 of 8
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  2. Topics in the News

    1. (8 articles) Royal Brompton Hospital
    2. (8 articles) Carlo Di Mario
    3. (8 articles) Nicolas Foin
    4. (7 articles) Imperial College London
    5. (3 articles) National University of Singapore
    6. (3 articles) Michaƫl J. A. Girard
    7. (2 articles) University College London
    8. (2 articles) Abbot
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    Imaging of coronary artery plaques using contrast-enhanced optical coherence tomography Feature Of The Week 9/9/12: Imaging of Coronary Artery Plaques Using Contrast Enhanced Optical Coherence Tomography Intracoronary imaging using attenuation-compensated optical coherence tomography allows better visualisation of coronary artery diseases Bioabsorbable scaffold optimization in provisional stenting: insight from optical coherence tomography Early coverage of Bioabsorbable Scaffold after STEMI analysed by 2D and 3D optical coherence tomography Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition First Optical Coherence Tomography Follow-up of Coronary Bifurcation Lesions Treated by Drug-Eluting Balloons Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs Optical coherence tomography features of neovascularization in proliferative diabetic retinopathy: a systematic review Retinal microvascular metrics in untreated essential hypertensives using optical coherence tomography angiography Optical coherence tomography angiography findings of fellow eye of proliferative macular telangiectasia type 2: Long term study Reorganization of the perifoveal microvasculature after macular hole closure assessed via optical coherence tomography angiography