1. Articles from Carroll A. B. Webers

    1-24 of 24
    1. Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma

      Optical Coherence Tomography Angiography and Visual Field Progression in Primary Angle Closure Glaucoma

      Precis: Lower whole enface disc (coefficient: 0.02, P =0.03) and macular vessel densities (coefficient: 0.04, P =0.02) on OCT angiography were significantly associated with faster rate of mean deviation decline. Purpose: To evaluate the association between optical coherence tomography angiography (OCTA) features and prior visual field (VF) progression in primary angle closure glaucoma (PACG). Methods: In a cross-sectional study, 46 eyes of 31 PACG patients with 5 reliable VF examinations performed over ≥3 years of follow-up underwent OCTA imaging. Effect of clinical (age, gender, number of anti-glaucoma medications, mean and SD of intraocular pressure during follow-up ...

      Read Full Article
    2. Vascular risk factors for optical coherence tomography-detected macular cysts: The Maastricht Study

      Vascular risk factors for optical coherence tomography-detected macular cysts: The Maastricht Study

      Purpose: To investigate whether higher blood pressure and greater arterial stiffness are associated with the presence of macular cysts and whether this association is already present in the absence of micro-aneurysms in individuals with and without type 2 diabetes. Methods: Using spectral domain optical coherence tomography (OCT), we performed a macular volume scan in 2647 individuals (mean age 60 ± 8 years, 50% men, 27% type 2 diabetes). The association between macular cysts and 24-hour systolic and diastolic blood pressure, pulse pressure, mean arterial blood pressure, carotid-femoral pulse wave velocity and carotid distensibility was assessed by use of logistic regression. Results ...

      Read Full Article
    3. Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes

      Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes

      Aim To compare the repeatability of peripapillary perfusion density and flux index measurements on referenced and non-referenced optical microangiography (OMAG) scans in normal, glaucoma suspect and glaucoma eyes. Methods In a cross-sectional study, 48 eyes (33 subjects) underwent three repeat, non-referenced peripapillary OMAG scans in the same session and 43 eyes (25 subjects) underwent three referenced peripapillary OMAG scans. In the referenced scan group, repeat scans (second and the third scan) were acquired exactly on the baseline (first) scan using the ‘track to prior scan’ option on the device. Repeatability estimates of the mean and four-sector (temporal, superior, nasal and ...

      Read Full Article
    4. Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes

      Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes

      Aims To compare the peripapillary vessel density (VD) measurements of high-density (HD) and non-HD optical coherence tomography angiography (OCTA) scans in normal and glaucoma eyes, and to evaluate the intrasession repeatability of VD measurements of HD scans. Methods In a cross-sectional study, 46 normal (33 subjects) and 89 glaucoma (64 patients) eyes underwent 3 HD and 1 non-HD optic nerve head OCTA scans in the same session. Agreement in VD measurements between HD and non-HD scans was assessed using Bland and Altman analysis. Repeatability of the VD measurements of HD scans was assessed using within-subject coefficient of repeatability (CRw) and ...

      Read Full Article
    5. Diagnostic Abilities of the Optical Microangiography Parameters of the 3×3 mm and 6×6 mm Macular Scans in Glaucoma

      Diagnostic Abilities of the Optical Microangiography Parameters of the 3×3 mm and 6×6 mm Macular Scans in Glaucoma

      Purpose: To evaluate the diagnostic abilities of macular vessel length and perfusion densities measured with optical microangiography (OMAG) over a 3×3 mm and a 6×6 mm region, and to compare these with macular ganglion cell-inner plexiform layer (GCIPL) thickness in eyes with primary open-angle glaucoma (POAG). Methods: In a cross-sectional study, 96 eyes of 57 control subjects and 88 eyes of 57 POAG patients underwent macular imaging with optical coherence tomography. Area under receiver operating characteristic curves (AUC) and sensitivities at 90% specificity of OMAG and GCIPL parameters were evaluated. Results: Most OMAG parameters of the 3×3 ...

      Read Full Article
    6. A Sectoral Analysis of Vessel Density Measurements in Perimetrically Intact Regions of Glaucomatous Eyes: An Optical Coherence Tomography Angiography Study

      A Sectoral Analysis of Vessel Density Measurements in Perimetrically Intact Regions of Glaucomatous Eyes: An Optical Coherence Tomography Angiography Study

      Purpose: To study sectoral vessel density (VD) and structural alterations in the peripapillary and parafoveal hemiretina corresponding to perimetrically intact regions of glaucomatous eyes with hemifield defects and to compare these with healthy eyes using optical coherence tomography. Methods: This cross-sectional study included 37 eyes with open-angle glaucoma having visual fields defects restricted to 1 hemifield and 45 age-matched controls. Peripapillary VD and retinal nerve fiber layer (RNFL) thickness were measured in 8 sectors. Parafoveal VD and ganglion cell complex thickness were measured in the superior and inferior hemispheres of the macula. These parameters were compared between the intact hemiretinae ...

      Read Full Article
      Mentions: Harsha L. Rao
    7. Reference values for anterior chamber morphometrics with swept-source optical coherence tomography in a Caucasian population

      Reference values for anterior chamber morphometrics with swept-source optical coherence tomography in a Caucasian population

      Purpose: The aim of this study is to generate reference values for anterior chamber morphometrics to facilitate the interpretation of anterior chamber images acquired with swept-source optical coherence tomography (SS-OCT) in a Caucasian population. Materials and methods: Non-glaucomatous Caucasian subjects, who were newly referred to the outpatient department of the University Eye Clinic Maastricht UMC+, were asked to undergo anterior segment assessment with SS-OCT imaging prior to routine eye examination (including visual acuity and refractive error measurements, Goldmann applanation tonometry, slit lamp examination and funduscopy). Results: A total of 647 Caucasian subjects, aged 40–80 years, were included. Mean age ...

      Read Full Article
    8. Prevalence of optical coherence tomography detected vitreomacular interface disorders: The Maastricht Study

      Prevalence of optical coherence tomography detected vitreomacular interface disorders: The Maastricht Study

      Purpose To calculate the prevalence of all vitreomacular interface (VMI) disorders and stratify according to age, sex and (pre)diabetes status. Methods The presence of VMI disorders was assessed in 2660 participants aged between 40 and 75 years from The Maastricht Study who had a gradable macular spectral-domain optical coherence tomography (SD-OCT) volume scan in at least one eye [mean 59.7 ± 8.2 years, 50.2% men, 1531 normal glucose metabolism (NGM), 401 prediabetes, 728 type 2 diabetes (DM2, oversampled)]. A stratified and multivariable logistic regression analysis was used. Results The prevalence of the different VMI disorders for individuals ...

      Read Full Article
    9. Optical Coherence Tomography Angiography Vessel Density Measurements in Eyes With Primary Open-Angle Glaucoma and Disc Hemorrhage

      Optical Coherence Tomography Angiography Vessel Density Measurements in Eyes With Primary Open-Angle Glaucoma and Disc Hemorrhage

      Purpose: To compare the vessel density measurements of optic nerve head, peripapillary and macular regions in severity-matched primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH) using optical coherence tomography (OCT) angiography, and to compare their diagnostic abilities with that of the rim area, retinal nerve fiber layer and the ganglion cell complex thickness measurements on OCT. Methods: In a cross-sectional study, 66 eyes of 46 control subjects, 34 eyes of 33 POAG patients with DH (median mean deviation=−3.7 dB) and 63 eyes of 43 POAG patients without DH (median mean deviation=−3.8 dB) underwent ...

      Read Full Article
    10. Optical Coherence Tomography Angiography Vessel Density Measurements in Eyes with Primary Open Angle Glaucoma and Disc Hemorrhage

      Optical Coherence Tomography Angiography Vessel Density Measurements in Eyes with Primary Open Angle Glaucoma and Disc Hemorrhage

      Purpose: To compare the vessel density measurements of optic nerve head (ONH), peripapillary and macular regions in severity-matched primary open angle glaucoma (POAG) eyes with and without disc hemorrhage (DH) using optical coherence tomography (OCT) angiography (OCTA), and to compare their diagnostic abilities with that of the rim area, retinal nerve fiber layer and the ganglion cell complex thickness measurements on OCT. Methods: In a cross-sectional study, 66 eyes of 46 control subjects, 34 eyes of 33 POAG patients with DH (median mean deviation, MD: -3.7 dB) and 63 eyes of 43 POAG patients without DH (median MD: -3 ...

      Read Full Article
    11. Relationship of Optic Nerve Structure and Function to Peripapillary Vessel Density Measurements of Optical Coherence Tomography Angiography in Glaucoma

      Relationship of Optic Nerve Structure and Function to Peripapillary Vessel Density Measurements of Optical Coherence Tomography Angiography in Glaucoma

      Purpose: To evaluate the sectoral and global structure-structure (vessel density-retinal nerve fiber layer thickness) and structure-function (vessel density-visual sensitivity loss) relationships of peripapillary vessel density measurements on optical coherence tomography angiography in primary open-angle glaucoma and to determine if fractional polynomial (FP) models characterize the relationships better than linear models. Materials and Methods: In a cross-sectional study, structure-structure and structure-function relationships of peripapillary vessel densities were determined in 227 eyes of 143 subjects (63 control and 164 primary open-angle glaucoma eyes) who had undergone standard automated perimetry and optical coherence tomography testing within 6 months of each other, using linear ...

      Read Full Article
    12. A comparison of the diagnostic ability of vessel density and structural measurements of optical coherence tomography in primary open angle glaucoma

      A comparison of the diagnostic ability of vessel density and structural measurements of optical coherence tomography in primary open angle glaucoma

      Purpose To compare the diagnostic abilities of vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary open angle glaucoma (POAG) with that of the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements. Methods In a cross sectional study, 78 eyes of 50 control subjects and 117 eyes of 67 POAG patients underwent vessel density and structural measurements with spectral domain OCT. POAG was diagnosed based on the masked evaluation of optic disc stereo photographs. Area ...

      Read Full Article
    13. Vessel density and structural measurements of optical coherence tomography in primary angle closure and primary angle closure glaucoma

      Vessel density and structural measurements of optical coherence tomography in primary angle closure and primary angle closure glaucoma

      Purpose To evaluate the vessel density measurements of the optic nerve head (ONH), peripapillary and macular regions on optical coherence tomography (OCT) angiography in eyes with primary angle closure (PAC) and primary angle closure glaucoma (PACG), and to compare their diagnostic abilities with the ONH rim area, peripapillary retinal nerve fiber layer (RNFL) thickness and the macular ganglion cell complex (GCC) thickness measurements on OCT in PACG. Design Cross-sectional study Methods Seventy-seven eyes of 50 control subjects, 65 eyes of 45 patients with PACG, and 31 eyes of 22 PAC patients with a history of high IOP, underwent imaging with ...

      Read Full Article
    14. Diagnostic ability of peripapillary vessel density measurements of optical coherence tomography angiography in primary open-angle and angle-closure glaucoma

      Diagnostic ability of peripapillary vessel density measurements of optical coherence tomography angiography in primary open-angle and angle-closure glaucoma

      Aims To evaluate the diagnostic ability of peripapillary vessel density measurements on optical coherence tomography angiography (OCTA) in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), and to compare these with peripapillary retinal nerve fibre layer (RNFL) thickness measurements. Methods In a cross-sectional study, 48 eyes of 33 healthy control subjects, 63 eyes of 39 patients with POAG and 49 eyes of 32 patients with PACG underwent OCTA (RTVue-XR, Optovue, Fremont, California, USA) and RNFL imaging with spectral domain OCT. Diagnostic abilities of vessel density and RNFL parameters were evaluated using area under receiver operating characteristic curves (AUC) and ...

      Read Full Article
    15. Foveal Layer Morphology Detected on Spectral Domain Optical Coherence Tomography and its Correlation with Visual Acuity in Asian Indian Premature Infants in their First Year of Life

      Foveal Layer Morphology Detected on Spectral Domain Optical Coherence Tomography and its Correlation with Visual Acuity in Asian Indian Premature Infants in their First Year of Life

      Purpose : To report foveal microanatomy imaged on handheld spectral domain optical coherence tomography (SDOCT) and correlate it with visual acuity in Asian Indian premature infants. Methods: A retrospective analysis of 32 Asian Indian premature infants, 10 with Type 2 retinopathy of prematurity (ROP), were imaged between 3 and 12 months of corrected postmenstrual age (PMA) on the handheld SDOCT (Envisu 2300, Bioptigen, DNC, USA). The foveal findings on these images were correlated with visual acuity measured using Teller acuity cards. The study cohort was divided into three groups based on the corrected age, 3–<6 months, 6–<9 months, and ...

      Read Full Article
      Mentions: Leica
    16. Regional comparisons of optical coherence tomography angiography vessel density in primary open angle glaucoma

      Regional comparisons of optical coherence tomography angiography vessel density in primary open angle glaucoma

      Purpose To compare the diagnostic abilities of the vessel densities in optic nerve head (ONH), peripapillary and macular regions measured using optical coherence tomography angiography (OCTA) in eyes with primary open angle glaucoma (POAG), and to evaluate the effect of glaucoma severity (based on the mean deviation, MD), optic disc size and pre-treatment intraocular pressure (IOP). Design Cross-sectional study Methods Seventy-eight eyes of 53 control subjects and 64 eyes of 39 POAG patients underwent OCTA imaging. Area under receiver operating characteristic (ROC) curves (AUC) and sensitivities at fixed specificities of vessel densities in ONH, peripapillary and macular regions were analyzed ...

      Read Full Article
    17. New ophthalmologic imaging techniques for detection and monitoring of neurodegenerative changes in diabetes: a systematic review

      New ophthalmologic imaging techniques for detection and monitoring of neurodegenerative changes in diabetes: a systematic review

      Optical coherence tomography (OCT) of the retina and around the optic nerve head and corneal confocal microscopy (CCM) are non-invasive and repeatable techniques that can quantify ocular neurodegenerative changes in individuals with diabetes. We systematically reviewed studies of ocular neurodegenerative changes in adults with type 1 or type 2 diabetes and noted changes in the retina, the optic nerve head, and the cornea. Of the 30 studies that met our inclusion criteria, 14 used OCT and 16 used CCM to assess ocular neurodegenerative changes. Even in the absence of diabetic retinopathy, several layers in the retina and the mean retinal ...

      Read Full Article
    18. Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians

      Purpose: To assess the reproducibility of iridocorneal angle (ICA) analysis in young, healthy Caucasian subjects using swept-source optical coherence tomography (SS-OCT) by determining variability and inter-observer agreement between expert and non-expert observers. Methods: Thirty-one healthy volunteers (non-experts) acquired 3 consecutive SS-OCT images of the right eyes of their peer non-experts. Images were analyzed by 31 non-experts and additionally by 3 experts, whereby the angle opening distance (AOD) and the trabecular iris space area (TISA) at 500µm and 750µm were calculated. A random intercept model was used to determine the amount of variation between observers. In addition, the intra-observer ...

      Read Full Article
    19. Value of optical coherence tomography for anterior segment surgery

      Value of optical coherence tomography for anterior segment surgery
      Anterior segment optical coherence tomography (AS-OCT) is an important new noncontact imaging technology that uses a 1310 nm super luminescent diode. It can be used to assess anterior chamber biometry, corneal thickness, lens thickness, and angle configuration; to visualize pathological processes; to evaluate postsurgical anatomy and posttraumatic eyes; and to image phakic intraocular lenses and intracorneal ring segments. Because it is a noncontact technique, it can also be used intraoperatively, which could be useful during trabeculectomy and after deep anterior lamellar keratoplasty to detect abnormalities in the cornea and interface. A disadvantage of AS-OCT is its inability to penetrate the ...
      Read Full Article
    20. Use of Anterior Segment Optical Coherence Tomography to Study Corneal Changes after Collagen Cross-linking

      Purpose: To investigate the stromal demarcation line after corneal cross-linking using anterior segment optical coherence tomography (AS-OCT) and its influence on the short-term results of cross-linking in patients with progressive keratoconus.Design: Prospective, nonrandomized study.Methods: Twenty-nine eyes of 29 patients with progressive keratoconus (n = 28) or after laser in situ keratomileusis ectasia (n = 1) were included and treated with corneal cross-linking at our institution. Measurements at 1, 3, 6, and 12 months after corneal cross-linking were: refraction, best-corrected visual acuity (BCVA), tonometry, corneal topography, AS-OCT, specular microscopy, and aberrometry. Demarcation line depth was measured centrally, 2 mm temporally, and ...
      Read Full Article
    21. Comparison of central corneal thickness and anterior chamber depth measurements using three imaging technologies in normal eyes and after phakic intraocular lens implantation

      Abstract: Background  The repeatability and interchangeability of imaging devices measuring central corneal thickness (CCT) and anterior chamber depth (ACD) are important in the assessment of patients considering refractive surgery. The purpose of this study was to investigate the agreement of CCT and ACD measurements using three imaging technologies in healthy eyes and in eyes after phakic intraocular lens implantation (pIOL). Methods  In this comparative study, CCT and ACD were measured using anterior segment optical coherence tomography (AS-OCT), Orbscan II, and Pentacam in 33 healthy volunteers (66 eyes) and 22 patients (42 eyes) after pIOL implantation. Intraobserver repeatability was evaluated for ...
      Read Full Article
    22. Value of preoperative phakic intraocular lens simulation using optical coherence tomography

      Purpose: To compare the position of the iris-fixated phakic intraocular lens (pIOL) in preoperative simulation and after implantation using anterior segment optical coherence tomography (AS-OCT). Setting: Department of Ophthalmology, Academic Hospital Maastricht, Maastricht, The Netherlands. Methods In this prospective study, the morphometrics of the anterior chamber were analyzed using preoperative pIOL simulation and postoperative images assessed with AS-OCT. Patients' eyes were examined before and 6 months after pIOL implantation. The measured distances were from the center of the pIOL to the endothelium, from the edge of the pIOL to the endothelium (nasal and temporal side), and from the back of ...
      Read Full Article
    23. Influence of anterior chamber morphometrics on endothelial cell changes after phakic intraocular lens implantation

      Purpose: To analyze the position of iris-fixated phakic intraocular lenses (pIOLs) using anterior segment optical coherence tomography (AS-OCT) and evaluate the effect of anterior chamber morphometrics on endothelial cell changes.Setting: Department of Ophthalmology, Academic Hospital Maastricht, The Netherlands.Methods: In this cross-sectional study, AS-OCT was used to measure the distances from the center and the edges of the pIOL to the corneal endothelium in 242 eyes with various models of myopic pIOLs. Endothelial cell measurements were performed preoperatively and at each follow-up examination.Results: The mean follow-up was 34.1 months ± 24.7 (SD) (range 3 months to 7 ...
      Read Full Article
    1-24 of 24
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (13 articles) Academic Hospital Maastricht
    2. (11 articles) Harsha L. Rao
    3. (11 articles) Robert N. Weinreb
    4. (10 articles) UCSD
    5. (5 articles) Muriël Doors
    6. (2 articles) University of Colorado
    7. (2 articles) Fred Hendrikse
    8. (2 articles) Optovue
    9. (1 articles) Rohit Shetty
    10. (1 articles) Leica
    11. (1 articles) National Taiwan University
    12. (1 articles) Medical University of Vienna
    13. (1 articles) UCSD
  3. Popular Articles

  4. Picture Gallery

    Value of optical coherence tomography for anterior segment surgery Reproducibility of anterior chamber angle analyses with the Swept Source Optical Coherence Tomography in young, healthy Caucasians New ophthalmologic imaging techniques for detection and monitoring of neurodegenerative changes in diabetes: a systematic review Foveal Layer Morphology Detected on Spectral Domain Optical Coherence Tomography and its Correlation with Visual Acuity in Asian Indian Premature Infants in their First Year of Life Diagnostic ability of peripapillary vessel density measurements of optical coherence tomography angiography in primary open-angle and angle-closure glaucoma A comparison of the diagnostic ability of vessel density and structural measurements of optical coherence tomography in primary open angle glaucoma Deep learning differentiates between healthy and diabetic mouse ears from optical coherence tomography angiography images Spectral-Domain Optical Coherence Tomography For Evaluating Palisades of Vogt in Ocular Surface Disorders With Limbal Involvement Oral cancer detection using optical coherence tomography – A detailed review Increased crystalline lens coverage in optical coherence tomography with oblique scanning and volume stitching Imaging Hyperreflective Foci as an Inflammatory Biomarker after Anti-VEGF Treatment in Neovascular Age-Related Macular Degeneration Patients with Optical Coherence Tomography Angiography Radiation-Induced Optical Coherence Tomography Angiography Retinal Alterations in Patients With Nasopharyngeal Carcinoma