1. Articles from William C. Warger

    1-3 of 3
    1. Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography

      Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography

      Optical coherence tomography (OCT) has been increasingly used for imaging pulmonary alveoli. Only a few studies, however, have quantified individual alveolar areas, and the validity of alveolar volumes represented within OCT images has not been shown. To validate quantitative measurements of alveoli from OCT images, we compared the cross-sectional area, perimeter, volume, and surface area of matched subpleural alveoli from microcomputed tomography (micro-CT) and OCT images of fixed air-filled swine samples. The relative change in size between different alveoli was extremely well correlated ( r > 0.9 , P < 0.0001 ), but OCT images underestimated absolute sizes compared to micro-CT by 27 ...

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    2. Differentiation of Early from Advanced Coronary Atherosclerotic Lesions: Systematic Comparison of CT, Intravascular US, and Optical Frequency Domain Imaging with Histopathologic Examination in ex Vivo Human Heart

      Differentiation of Early from Advanced Coronary Atherosclerotic Lesions: Systematic Comparison of CT, Intravascular US, and Optical Frequency Domain Imaging with Histopathologic Examination in ex Vivo Human Heart

      Purpose: To establish an ex vivo experimental setup for imaging coronary atherosclerosis with coronary computed tomographic (CT) angiography, intravascular ultrasonography (US), and optical frequency domain imaging (OFDI) and to investigate their ability to help differentiate early from advanced coronary plaques. Materials and Methods: All procedures were performed in accordance with local and federal regulations and the Declaration of Helsinki. Approval of the local Ethics Committee was obtained. Overall, 379 histologic cuts from nine coronary arteries from three donor hearts were acquired, coregistered among modalities, and assessed for the presence and composition of atherosclerotic plaque. To assess the discriminatory capacity of ...

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    3. Evaluation of optical reflectance techniques for imaging of alveolar structure

      Evaluation of optical reflectance techniques for imaging of alveolar structure

      Three-dimensional (3-D) visualization of the fine structures within the lung parenchyma could advance our understanding of alveolar physiology and pathophysiology. Current knowledge has been primarily based on histology, but it is a destructive two-dimensional (2-D) technique that is limited by tissue processing artifacts. Micro-CT provides high-resolution three-dimensional (3-D) imaging within a limited sample size, but is not applicable to intact lungs from larger animals or humans. Optical reflectance techniques offer the promise to visualize alveolar regions of the large animal or human lung with sub-cellular resolution in three dimensions. Here, we present the capabilities of three optical reflectance techniques, namely ...

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    1-3 of 3
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    1. (3 articles) Harvard University
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    Evaluation of optical reflectance techniques for imaging of alveolar structure Differentiation of Early from Advanced Coronary Atherosclerotic Lesions: Systematic Comparison of CT, Intravascular US, and Optical Frequency Domain Imaging with Histopathologic Examination in ex Vivo Human Heart Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography Cooperative low-rank models for removing stripe noise from OCTA images MS-CAM: Multi-Scale Class Activation Maps for Weakly-supervised Segmentation of Geographic Atrophy Lesions in SD-OCT Images Attention-guided 3D-CNN Framework for Glaucoma Detection and Structural-Functional Association using Volumetric Images Machine Learning Techniques for Ophthalmic Data Processing: A Review Dynamic Imaging of Mouse Embryos and Cardiac Development in Static Culture Effects of axial length on retinal nerve fiber layer and macular ganglion cell-inner plexiform layer measured by spectral-domain OCT Innovative method offers a new way of studying developmental cardiac biomechanics, live in 4-D Plaque mOrphology iMpact on Side Branch Occlusion at oPtical Coherence Tomography Evaluation in Percutaneous Coronary Interventions Full-range space-division multiplexing optical coherence tomography angiography