1. Articles from Eman Namati

    1-12 of 12
    1. Imaging Apparatus With Balloon And Shaped Tip

      Imaging Apparatus With Balloon And Shaped Tip

      Exemplary imaging apparatuses are described. Various imaging apparatuses may implement optical coherence tomography (OCT) and/or optical frequency domain imaging (OFDI) gastrointestinal tissue imaging methods and technologies. Furthermore, the imaging apparatuses may include a rotatable imaging element to scan a bodily lumen, such as the esophagus. The imaging element may be housed within an inflatable balloon. Still further, the imaging apparatuses may include a shaped tip. The shaped tip may aid in guiding an imaging apparatus through the esophagus, or other bodily lumen.

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    2. Optical coherence tomography in gastroenterology: a review and future outlook

      Optical coherence tomography in gastroenterology: a review and future outlook

      Optical coherence tomography (OCT) is an imaging technique optically analogous to ultrasound that can generate depth-resolved images with micrometer-scale resolution. Advances in fiber optics and miniaturized actuation technologies allow OCT imaging of the human body and further expand OCT utilization in applications including but not limited to cardiology and gastroenterology. This review article provides an overview of current OCT development and its clinical utility in the gastrointestinal tract, including disease detection/differentiation and endoscopic therapy guidance, as well as a discussion of its future applications.

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    3. Apparatus and methods for producing and/or providing recirculating optical delay(s)

      Apparatus and methods for producing and/or providing recirculating optical delay(s)

      Exemplary apparatus and method can be availed for providing at least one electromagnetic radiation. For example, it is possible to provide at least one first electromagnetic radiation having a frequency that changes over time with a first characteristic period. Further, with at least one hardware arrangement, it is possible to receive and modify the first electromagnetic radiation(s) into at least one second electromagnetic radiation having a frequency that changes over time with a second characteristic period. The second characteristic period can be smaller than the first characteristic period. The hardware arrangement(s) can include a resonant cavity having a ...

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    4. Imaging system producing multiple registered images of a body lumen

      Imaging system producing multiple registered images of a body lumen

      Systems, devices and methods for producing registered images of a body lumen are provided. The system includes a first imaging device having an imager positioned at a distal end thereof, said first imaging device configured to produce a first image of a body cavity; and an imaging system, including a second imaging device having an imager positioned at a distal end thereof and configured to be positioned approximate to said imager of said first imaging device within said body cavity and configured to produce a second image; an elongated member configured to contain said second imaging device; and at least ...

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    5. FREQUENCY-DOMAIN Optical Coherence Tomography With Extended FIELD-OF-VIEW And Reduction Of Aliasing Artifacts

      FREQUENCY-DOMAIN Optical Coherence Tomography With Extended FIELD-OF-VIEW And Reduction Of Aliasing Artifacts

      The present disclosure provides an OCT imaging system to reduce or eliminate frequency-domain aliasing artifacts. The frequency is shifted using a carrier frequency to define a sampling range substantially centered on the carrier frequency. An image of the sample is generated from a displayed imaging range that consists of a subset of the frequencies within the sampling range.

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    6. Four-dimensional visualization of subpleural alveolar dynamics in vivo during uninterrupted mechanical ventilation of living swine

      Four-dimensional visualization of subpleural alveolar dynamics in vivo during uninterrupted mechanical ventilation of living swine

      Pulmonary alveoli have been studied for many years, yet no unifying hypothesis exists for their dynamic mechanics during respiration due to their miniature size (100-300 μm dimater in humans) and constant motion, which prevent standard imaging techniques from visualizing four-dimensional dynamics of individual alveoli in vivo . Here we report a new platform to image the first layer of air-filled subpleural alveoli through the use of a lightweight optical frequency domain imaging (OFDI) probe that can be placed upon the pleura to move with the lung over the complete range of respiratory motion. This device enables in-vivo acquisition of four-dimensional microscopic ...

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    7. Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

      Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

      Background : Optical coherence tomography(OCT) allows tissue histologic-like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroid surgeries to provide a preliminary assessment as to whether these images contain sufficient information for recognition and differentiation of normal neck tissues. Methods : Normal tissues were obtained from patients undergoing surgical treatment. Two new-generations OCT systems including optical frequency domain imaging(OFDI) and µOCT were compared to representative H&E histology. Results : Thyroid, fat, muscle, lymph nodes, and parathyroid tissues were evaluated. Histologic-like microscopic characteristics sufficient for tissue type identification was realized using both ...

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    8. Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography

      Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography

      Optical coherence tomography (OCT) has been increasingly used for imaging pulmonary alveoli. Only a few studies, however, have quantified individual alveolar areas, and the validity of alveolar volumes represented within OCT images has not been shown. To validate quantitative measurements of alveoli from OCT images, we compared the cross-sectional area, perimeter, volume, and surface area of matched subpleural alveoli from microcomputed tomography (micro-CT) and OCT images of fixed air-filled swine samples. The relative change in size between different alveoli was extremely well correlated ( r > 0.9 , P < 0.0001 ), but OCT images underestimated absolute sizes compared to micro-CT by 27 ...

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    9. Evaluation of optical reflectance techniques for imaging of alveolar structure

      Evaluation of optical reflectance techniques for imaging of alveolar structure

      Three-dimensional (3-D) visualization of the fine structures within the lung parenchyma could advance our understanding of alveolar physiology and pathophysiology. Current knowledge has been primarily based on histology, but it is a destructive two-dimensional (2-D) technique that is limited by tissue processing artifacts. Micro-CT provides high-resolution three-dimensional (3-D) imaging within a limited sample size, but is not applicable to intact lungs from larger animals or humans. Optical reflectance techniques offer the promise to visualize alveolar regions of the large animal or human lung with sub-cellular resolution in three dimensions. Here, we present the capabilities of three optical reflectance techniques, namely ...

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    10. Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

      Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

      Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for ...

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    1-12 of 12
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    Evaluation of optical reflectance techniques for imaging of alveolar structure Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section Four-dimensional visualization of subpleural alveolar dynamics in vivo during uninterrupted mechanical ventilation of living swine Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo Optical Coherence Tomography Optical Probe Systems And Methods To Reduce Artifacts Imaging system producing multiple registered images of a body lumen Apparatus and methods for producing and/or providing recirculating optical delay(s) Angular image manipulation Optical coherence tomography in gastroenterology: a review and future outlook Optical coherence tomography angiography of foveal neovascularisation in proliferative diabetic retinopathy Treating port wine stain birthmarks using dynamic optical coherence tomography-guided setting