1. Articles from Traci E. Clemons

    1-6 of 6
    1. Retinal specialist versus artificial intelligence detection of retinal fluid from optical coherence tomography: AREDS2 10-year Follow-On

      Retinal specialist versus artificial intelligence detection of retinal fluid from optical coherence tomography: AREDS2 10-year Follow-On

      Purpose To evaluate the performance of retinal specialists in detecting retinal fluid presence in spectral domain optical coherence tomography (SD-OCT) macular volume scans from eyes with age-related macular degeneration (AMD), and to compare performance with the artificial intelligence (AI)-based Notal OCT Analyzer (NOA). Design Prospective comparison of retinal fluid grades from human retinal specialists and the NOA on SD-OCT scans from two commonly used devices (Cirrus and Spectralis). Participants 1,127 eyes of 651 Age-Related Eye Disease Study 2 10-year (AREDS2-10Y) participants with SD-OCT scans graded for fluid presence/absence by reading center (RC) graders. Methods The AREDS2-10Y investigators ...

      Read Full Article
    2. Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome

      Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome

      Purpose To validate the efficacy of a fully-automatic, deep learning-based segmentation algorithm beyond conventional performance metrics by measuring the primary outcome of a clinical trial for macular telangiectasia type 2 (MacTel2) Design Evaluation of diagnostic test or technology Participants 92 eyes from 62 participants with MacTel2 from a phase 2 clinical trial (NCT01949324) randomized to one of two treatment groups Methods The ellipsoid zone (EZ) defect areas were measured on spectral domain optical coherence tomography images of each eye at two time points (Baseline and Month 24) by a fully-automatic, deep learning-based segmentation algorithm. The change in EZ defect area ...

      Read Full Article
      Mentions: Duke University
    3. Correlation Between Macular Integrity Assessment and Optical Coherence Tomography Imaging of Ellipsoid Zone in Macular Telangiectasia Type 2

      Correlation Between Macular Integrity Assessment and Optical Coherence Tomography Imaging of Ellipsoid Zone in Macular Telangiectasia Type 2

      Purpose : To correlate ellipsoid zone (EZ) defects on spectral-domain optical coherence tomography (SD-OCT) with retinal sensitivity loss on macular integrity assessment (MAIA) microperimetry in macular telangiectasia type 2 (MacTel). Methods : Macular SD-OCT volumes and microperimetry maps were obtained during the international, multicenter, randomized phase 2 trial of ciliary neurotrophic factor for type 2 MacTel on two visits within 5 days of one another. Software was developed to register SD-OCT to MAIA scanning laser ophthalmoscopy images and to overlay EZ defect areas on the microperimetry maps generated from microperimetry sensitivity values at specific points and from interpolated sensitivity values. A total ...

      Read Full Article
      Mentions: Duke University
    4. Multimodal Imaging In Type 2 Idiopathic Macular Telangiectasia

      Multimodal Imaging In Type 2 Idiopathic Macular Telangiectasia

      Background: Macular telangiectasia Type 2 is a bilateral, progressive potentially blinding retinal disease characterized by both vascular and neurodegenerative signs that have been documented using different imaging techniques. The correlation between macular telangiectasia Type 2 signs from various imaging modalities is unknown. Our aim was to investigate the relationship of various macular telangiectasia Type 2 signs using fundus fluorescein angiography, optical coherence tomography and dual-wavelength autofluorescence images. Methods: Participants were selected from the macular telangiectasia Type 2 Natural History Observation Study, based on a confirmed diagnosis and the availability of images. Signs in fundus fluorescein angiography, dual-wavelength autofluorescence, and optical ...

      Read Full Article
    5. 'En face' OCT imaging of the IS/OS junction line in Type 2 Idiopathic Macular Telangiectasia

      'En face' OCT imaging of the IS/OS junction line in Type 2 Idiopathic Macular Telangiectasia

      Purpose: To investigate abnormalities of the photoreceptor inner/outer segment (IS/OS) junction layer viewed 'en face' and their functional correlates in Type 2 Idiopathic Macular Telangiectasia (type 2 MacTel). Methods: Segmentation and 'en face' imaging of the IS/OS lines in spectral domain optical coherence tomographic (SD-OCT) volumes were performed manually. Mesopic retinal sensitivity thresholds were determined using a Nidek MP1 microperimeter. 'En face' SD-OCT images and microperimetric data were superimposed over images of the fundus. Retinal structure and characteristics of type 2 MacTel were analyzed, associations of structural changes with function were investigated. Results: Forty-nine eyes of 28 ...

      Read Full Article
    6. Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD

      Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD

      Purpose: Macular hyperpigmentation is associated with progression from intermediate to advanced age-related macular degeneration (AMD). The purpose of this study was to accurately correlate hyperpigmentary changes with spectral domain optical coherence tomography (SDOCT) hyperreflective foci in eyes with non-advanced AMD. Methods: A prospective cross-sectional analysis of 314 eyes (314 subjects) with intermediate AMD was performed in the multicenter AREDS2 Ancillary SDOCT Study to correlate hyperpigmentary changes on color fundus photographs (CFP) with abnormal morphology on SDOCT. Spatial coregistration was performed with an automated algorithm in 2 non-overlapping subsets of 20 study eyes with double-masked CFP and SDOCT grading by certified ...

      Read Full Article
    1-6 of 6
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (3 articles) Duke University
    2. (3 articles) National Institutes of Health
    3. (1 articles) University of Sydney
    4. (1 articles) University of Bern
    5. (1 articles) University of Wisconsin
    6. (1 articles) University College London
    7. (1 articles) Cleveland Clinic
    8. (1 articles) Nidek
    9. (1 articles) Carl Zeiss Meditec
    10. (1 articles) Notal Vision
    11. (1 articles) Columbia University
    12. (1 articles) University of Rochester
    13. (1 articles) Stanford University
    14. (1 articles) Johns Hopkins University
    15. (1 articles) National University of Singapore
  3. Popular Articles

  4. Picture Gallery

    Spatial correlation between hyperpigmentary changes on color fundus photography and hyperreflective foci on SDOCT in intermediate AMD 'En face' OCT imaging of the IS/OS junction line in Type 2 Idiopathic Macular Telangiectasia Multimodal Imaging In Type 2 Idiopathic Macular Telangiectasia Correlation Between Macular Integrity Assessment and Optical Coherence Tomography Imaging of Ellipsoid Zone in Macular Telangiectasia Type 2 Beyond Performance Metrics: Automatic Deep Learning Retinal OCT Analysis Reproduces Clinical Trial Outcome Retinal specialist versus artificial intelligence detection of retinal fluid from optical coherence tomography: AREDS2 10-year Follow-On Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea Optical coherence tomography image based eye disease detection using deep convolutional neural network Optical Coherence Tomography Biomarkers in Predicting Treatment Outcomes of Diabetic Macular Edema After Dexamethasone Implants Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images Optical coherence tomography assessment of the enamel surface after debonding the ceramic brackets using three different techniques