1. Articles from Gerald Brandacher

    1-8 of 8
    1. Evaluation of Microvascular Anastomosis Using Real-Time, Ultra-High-Resolution, Fourier Domain Doppler Optical Coherence Tomography

      Evaluation of Microvascular Anastomosis Using Real-Time, Ultra-High-Resolution, Fourier Domain Doppler Optical Coherence Tomography

      Background: Evolution in microsurgical techniques and tools has paved the way for supermicrosurgical anastomoses, with vessel diameters often approaching below 0.8 mm in the clinical realm and even smaller (0.2 to 0.3 mm) in murine models. Several imaging and monitoring devices have been introduced for postoperative monitoring, but intraoperative guidance, assessment, and predictability have remained limited to binocular optical microscopy and the surgeon’s experience. The authors present a high-resolution, real-time, three-dimensional imaging modality for intraoperative evaluation of luminal narrowing, thrombus formation, and flow alterations. Methods: An imaging modality that provides immediate, in-depth, high-resolution, three-dimensional structure view ...

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    2. MEMS-Based Handheld Fourier Domain Doppler Optical Coherence Tomography for Intraoperative Microvascular Anastomosis Imaging

      MEMS-Based Handheld Fourier Domain Doppler Optical Coherence Tomography for Intraoperative Microvascular Anastomosis Imaging

      Purpose To demonstrate the feasibility of a miniature handheld optical coherence tomography (OCT) imager for real time intraoperative vascular patency evaluation in the setting of super-microsurgical vessel anastomosis. Methods A novel handheld imager Fourier domain Doppler optical coherence tomography based on a 1.3-µm central wavelength swept source for extravascular imaging was developed. The imager was minimized through the adoption of a 2.4-mm diameter microelectromechanical systems (MEMS) scanning mirror, additionally a 12.7-mm diameter lens system was designed and combined with the MEMS mirror to achieve a small form factor that optimize functionality as a handheld extravascular OCT ...

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    3. Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

      Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

      Vascular and microvascular anastomosis are critical components of reconstructive microsurgery, vascular surgery and transplant surgery. Imaging modality that provides immediate, real-time in-depth view and 3D structure and flow information of the surgical site can be a great valuable tool for the surgeon to evaluate surgical outcome following both conventional and innovative anastomosis techniques, thus potentially increase the surgical success rate. Microvascular anastomosis for vessels with outer diameter smaller than 1.0 mm is extremely challenging and effective evaluation of the outcome is very difficult if not impossible using computed tomography (CT) angiograms, magnetic resonance (MR) angiograms and ultrasound Doppler. Optical ...

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    4. OCT-aided anastomosis platform study in the rodent model

      OCT-aided anastomosis platform study in the rodent model

      Anastomosis is one of the most commonly performed procedure in the clinical environment that involves tubular structures, such as blood vessel, lymphatic vessel, seminal duct and ureter. Suture based anastomosis is still the foundation for most basic surgical training and clinical operation, although alternate techniques have been developed and under development. For those tubular-structure-anastomosis, immediate real-time post-operative evaluation of the surgical outcome is critical to the success of surgery. Previously evaluation is mostly based on surgeons' experience. Fourier-domain optical coherence tomography is high-speed, high-resolution noninvasive 3D imaging modality that has been widely used in the biomedical research and clinical study ...

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    5. In Vivo Real-time Ultra-fast 3D Fourier Domain Optical Coherence Tomography Imaging of Anastomoses for Super-microsurgical Research

      In Vivo Real-time Ultra-fast 3D Fourier Domain Optical Coherence Tomography Imaging of Anastomoses for Super-microsurgical Research

      PURPOSE: The emergence of supermicrosurgery has enabled reconstructive surgery to enter into a new era by advancing a series of novel techniques including lymphaticovenous anastomosis, fingertip replantation, and perforator flap surgery. Nonetheless, super-microsurgery techniques impose great technical challenges. The instant monitoring and evaluation of the patency of the anastomosis, in particular of intraluminal structure, is critical to be able to predict the necessity of early re-intervention and thus reduce/avoid complications and improve surgical success rates. Real-time 3D fourier-domain optical coherence tomography (3D FD-OCT) is a powerful imaging system, which uniquely provides noninvasive, in vivo real-time images on a micrometer-scale ...

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    6. Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography

      Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography

      Vascular and microvascular anastomoses are critical components of reconstructive microsurgery, vascular surgery, and transplant surgery. Intraoperative surgical guidance using a surgical imaging modality that provides an in-depth view and three-dimensional (3-D) imaging can potentially improve outcome following both conventional and innovative anastomosis techniques. Objective postoperative imaging of the anastomosed vessel can potentially improve the salvage rate when combined with other clinical assessment tools, such as capillary refill, temperature, blanching, and skin turgor. Compared to other contemporary postoperative monitoring modalities-computed tomography angiograms, magnetic resonance (MR) angiograms, and ultrasound Doppler-optical coherence tomography (OCT) is a noninvasive high-resolution (micron-level), high-speed, 3-D imaging modality ...

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    7. Real-time 3D Fourier-domain optical coherence tomography guided microvascular anastomosis

      Real-time 3D Fourier-domain optical coherence tomography guided microvascular anastomosis

      Vascular and microvascular anastomosis is considered to be the foundation of plastic and reconstructive surgery, hand surgery, transplant surgery, vascular surgery and cardiac surgery. In the last two decades innovative techniques, such as vascular coupling devices, thermo-reversible poloxamers and suture-less cuff have been introduced. Intra-operative surgical guidance using a surgical imaging modality that provides in-depth view and 3D imaging can improve outcome following both conventional and innovative anastomosis techniques. Optical coherence tomography (OCT) is a noninvasive high-resolution (micron level), high-speed, 3D imaging modality that has been adopted widely in biomedical and clinical applications. In this work we performed a proof-of-concept ...

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    8. Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries

      Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries

      The authors describe the development of an ultrafast three-dimensional (3D) optical coherence tomography (OCT) imaging system that provides real-time intraoperative video images of the surgical site to assist surgeons during microsurgical procedures. This system is based on a full-range complex conjugate free Fourier-domain OCT (FD-OCT). The system was built in a CPU-GPU heterogeneous computing architecture capable of video OCT image processing. The system displays at a maximum speed of 10  volume/?startsend? for an image volume size of 160×80×1024 (X×Y×Z) pixels. We have used this system to visualize and guide two prototypical microsurgical maneuvers: microvascular anastomosis ...

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    1-8 of 8
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  2. Topics in the News

    1. (8 articles) Johns Hopkins University
    2. (8 articles) Yong Huang
    3. (8 articles) Gerald Brandacher
    4. (7 articles) Jin U. Kang
    5. (6 articles) Shan Zhu
    6. (2 articles) University of Rochester
    7. (1 articles) Kang Zhang
    8. (1 articles) Peter L. Gehlbach
    9. (1 articles) Centre Hospitalier Intercommunal de Créteil
    10. (1 articles) Mount Sinai School of Medicine
    11. (1 articles) Geunyoung Yoon
    12. (1 articles) Eric H. Souied
    13. (1 articles) Francesco Bandello
    14. (1 articles) Egidijus Auksorius
    15. (1 articles) Maciej Wojtkowski
    16. (1 articles) Giuseppe Querques
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    Real-time three-dimensional Fourier-domain optical coherence tomography video image guided microsurgeries Real-time 3D Fourier-domain optical coherence tomography guided microvascular anastomosis Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography In Vivo Real-time Ultra-fast 3D Fourier Domain Optical Coherence Tomography Imaging of Anastomoses for Super-microsurgical Research OCT-aided anastomosis platform study in the rodent model Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography MEMS-Based Handheld Fourier Domain Doppler Optical Coherence Tomography for Intraoperative Microvascular Anastomosis Imaging Evaluation of Microvascular Anastomosis Using Real-Time, Ultra-High-Resolution, Fourier Domain Doppler Optical Coherence Tomography Procedural and one-year outcomes of patients treated with orbital and rotational atherectomy with mechanistic insights from optical coherence tomography Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report OCT-A characterisation of recurrent type 3 macular neovascularisation Quantitative Coronary Angiography Can Predict Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients