1. Articles from Milosz Jaguszewski

    1-14 of 14
    1. Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures

      Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures

      Background There is limited knowledge about morphological molecular-imaging-derived parameters to further characterize hemodynamically relevant coronary lesions. Objective The aim of this study was to describe and differentiate specific parameters between hemodynamically significant and non-significant coronary lesions using various invasive and non-invasive measures. Methods This clinical study analyzed patients with symptoms suggestive of coronary artery disease (CAD) who underwent native T1-weighted CMR and gadofosveset-enhanced CMR as well as invasive coronary angiography. OCT of the culprit vessel to determine the plaque type was performed in a subset of patients. Functional relevance of all lesions was examined using quantitative flow reserve (QFR-angiography). Hemodynamically ...

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    2. Challenging treatment of in-stent restenosis in a coronary bifurcation by implantation of a bioresorbable scaffold under optical coherence tomography guidance

      Challenging treatment of in-stent restenosis in a coronary bifurcation by implantation of a bioresorbable scaffold under optical coherence tomography guidance

      A 67-year-old male patient with stable angina, hypertension and hypercholesterolemia who underwent bare metal stent (BMS) implantation in the distal right coronary artery (RCA) (Azule 3 × 9 mm) and everolimus-eluting stent (EES) implantation in the first diagonal branch (D1) (Xience 2.25 × 18 mm) and in the proximal circumflex branch (LCx) (Xience 3 × 28 mm). One year subsequent to the precedure the patient was readmitted for relapse of the angina Canadian Cardiovascular Society scale II, exhibiting a positive exercise test. The coronary angiography showed a distal-edge in-stent restenosis (ISR) in the distal RCA, extending to the posterior descending artery (PDA ...

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    3. Novel Approach for In Vivo Detection of Vulnerable Coronary Plaques Using Molecular 3-T CMR Imaging With an Albumin-Binding Probe

      Novel Approach for In Vivo Detection of Vulnerable Coronary Plaques Using Molecular 3-T CMR Imaging With an Albumin-Binding Probe

      Objectives This study sought to investigate the potential of the noninvasive albumin-binding probe gadofosveset-enhanced cardiac magnetic resonance (GE-CMR) for detection of coronary plaques that can cause acute coronary syndromes (ACS). Background ACS are frequently caused by rupture or erosion of coronary plaques that initially do not cause hemodynamically significant stenosis and are therefore not detected by invasive x-ray coronary angiography (XCA). Methods A total of 25 patients with ACS or symptoms of stable coronary artery disease underwent GE-CMR, clinically indicated XCA, and optical coherence tomography (OCT) within 24 h. GE-CMR was performed approximately 24 h following a 1-time application of ...

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    4. A formula to calculate the contrast volume required for optimal imaging quality in optical coherence tomography with non-occlusive technique

      A formula to calculate the contrast volume required for optimal imaging quality in optical coherence tomography with non-occlusive technique

      Background: Non-occlusive technique is universally accepted for acquisition of coronary optical coherence tomography (OCT), but the amount of contrast infused is still inconsistently calculated. Proposed herein, is an empirical formula for accurate contrast volume calculation. Methods: In an observational prospective study, contrast volume of consecutive patients undergoing OCT was either calculated with formula, or eyeballed based on manufacturer recommendations. The quality of pullback, defined as % of high quality cross-sections (CS) in the segment of interest (SOI), was analyzed by two independent operators and compared between groups, together with the amount of contrast per pullback. Results: Sixty patients (115 pullbacks, 4252 ...

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    5. Implantation of bioresorbable scaffolds under guidance of optical coherence tomography: feasibility and pilot clinical results of a systematic protocol

      Implantation of bioresorbable scaffolds under guidance of optical coherence tomography: feasibility and pilot clinical results of a systematic protocol

      Background: We hypothesise that a comprehensive optical coherence tomography (OCT)-guided implantation protocol for bioresorbable scaffolds (BRS) might improve expansion and apposition, thus translating into better clinical outcomes, particularly reducing thrombotic events. Methods: Patients considered suitable for BRS therapy in de novo coronary lesions underwent OCT. The predominant type of plaque was classified as lipidic, fibrous or calcific, undergoing tailored plaque preparation accordingly. After proper sizing, BRS was deployed and final OCT was acquired. Post-dilation was only performed if suboptimal deployment. Procedural and 12 months clinical follow-up are reported. Results: 29 patients (41 lesions) considered clinically and angiographically suitable for ...

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    6. Bas-relief in three dimensional optical coherence tomography: a novel sign after subintimal scaffolding in a chronic total occlusion

      Bas-relief in three dimensional optical coherence tomography: a novel sign after subintimal scaffolding in a chronic total occlusion

      A 69-years-old female with stable angina underwent percutaneous intervention of a chronic total occlusion (CTO) in the proximal right coronary artery (RCA) ( Panel A, Supplementary material online , Video S1 ). Septal collaterals supplied the distal vessel (Rentrop 3, CC1) ( Supplementary material online , Video S2 ).

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    7. The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical

      The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical

      Objectives The aim of the present study was to evaluate vascular healing of the bioengineered COMBO Dual Therapy Stent compared with a cobalt-chromium (CoCr) everolimus-eluting stent (EES) as assessed by optical coherence tomography in patients with acute coronary syndromes. Background CD34+ cells promote endothelial repair after vascular injury. The bioengineered COMBO Dual Therapy Stent combines CD34+ cell–capturing technology with abluminal sirolimus release, but more data from clinical studies evaluating the vascular response are needed. Methods In a prospective randomized multicenter clinical trial, 60 patients with acute coronary syndromes were randomized 1:1 to COMBO or CoCr EES implantation. The ...

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    8. Optical coherence tomography imaging after successful percutaneous coronary intervention treatment of coronary perforation following bioabsorbable vascular scaffold implantation: Consecutive ping-pong and child-in-mother techniques

      Optical coherence tomography imaging after successful percutaneous coronary intervention treatment of coronary perforation following bioabsorbable vascular scaffold implantation: Consecutive ping-pong and child-in-mother techniques

      A 68-year-old male, former smoker, with dyslipidemia, and 7-year history of stable angina was admitted to our center due to symptom progression and positive treadmill test under optimal medical treatment with aspirin, beta-blockers, and highdose statins. Transradial coronary angiography evidenced a chronic total occlusion (CTO) of the proximal left anterior descending artery (LAD), severe stenosis of the proximal left circumflex artery (LCx), and a dominant right coronary artery with collateral flow to the mid and distal bed of the LAD (Rentrop 3, CC 2). Left ventricular (LV)-angiography evidenced LV normal size and function. LCx stenosis was successfully treated with ...

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    9. Impact of local vascular lesions assessed with optical coherence tomography and ablation points on blood pressure reduction after renal denervation

      Impact of local vascular lesions assessed with optical coherence tomography and ablation points on blood pressure reduction after renal denervation

      Local vascular injury is detectable with optical coherence tomography (OCT) after catheter-based renal denervation (RDN). However, it is unclear whether the number and type of vascular lesions or the number of ablation points could affect blood pressure (BP) reduction. The aim of the study was to assess the impact of vascular injury induced by RDN detected with OCT and the number of ablation points on BP response after 1, 3 and 6 months. METHODS: RDN was either performed with a Simplicity ® catheter or an EnligHTN TM multielectrode basket followed by OCT. BP was recorded prospectively as office measurement and 24-hour ...

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    10. Optical coherence tomography to reveal vascular lesions after catheter-based renal nerve ablation with a novel multi-electrode EnligHTNTM system

      Optical coherence tomography to reveal vascular lesions after catheter-based renal nerve ablation with a novel multi-electrode EnligHTNTM system

      A 72-year-old female with a history of sleep apnoea syndrome was referred to the Andreas Gruentzig Catheterisation Laboratories for catheter-based renal nerve ablation (RNA) due to drug-resistant, uncontrolled hypertension. After intravenously loading with aspirin, the RNA was obtained using the first generation multi-electrode EnligHTNTM system (St. Jude Medical, Westford, MA, USA) delivering 8 ablation runs on both the left and the right renal artery. Before and after the RNA procedure, optical coherence tomography (OCT) was performed using the C7-XR imaging system (LightLab Imaging, Inc., Westford, MA, USA) with a non-occlusive technique and a single-mode optical fibre catheter (frequency domain-OCT-catheter, DragonFlyTM ...

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    11. Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation

      Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation

      A 78-year-old female was referred to the Andreas Gruentzig Catheterization Laboratories suffering from angina pain CCS II. Coronary angiography demonstrated a bifurcation lesion in the middle left anterior descending and the first diagonal branch ( Panel A ). Based on these findings, percutaneous coronary intervention (PCI) was performed with implantation of a

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    12. Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity® catheter system and the EnligHTN™ multi-electrode renal denervation catheter

      Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity® catheter system and the EnligHTN™ multi-electrode renal denervation catheter

      Aims Catheter-based renal nerve ablation (RNA) using radiofrequency energy is a novel treatment for drug-resistant essential hypertension. However, the local endothelial and vascular injury induced by RNA has not been characterized, although this importantly determines the long-term safety of the procedure. Optical coherence tomography (OCT) enables in vivo visualization of morphologic features with a high resolution of 10–15 µm. The objective of this study was to assess the morphological features of the endothelial and vascular injury induced by RNA using OCT. Methods and results In a prospective observational study, 32 renal arteries of patients with treatment-resistant hypertension underwent OCT ...

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    13. Optical coherence tomography to reveal strut malapposition due to thrombus resolution 3 weeks after acute coronary syndrome

      Optical coherence tomography to reveal strut malapposition due to thrombus resolution 3 weeks after acute coronary syndrome

      A 37-year-old male was admitted with a non-ST-elevation myocardial infarction. Coronary angiography and optical coherence tomography (OCT) revealed a 70% stenosis of the ostial left artery descending (LAD) with little thrombotic material but without obvious signs for rupture/dissection ( Panels A and B , Supplementary material online, Video S1 ). After direct stenting with a biolimus-eluting stent (BES, 3.5 × 18 mm, 10 atmospheres), OCT revealed suboptimal strut apposition with

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    14. Optical Coherence Tomography Imaging: Novel Insights into the Vascular Response After Coronary Stent Implantation

      Optical Coherence Tomography Imaging: Novel Insights into the Vascular Response After Coronary Stent Implantation

      Optical coherence tomography (OCT) is a high-resolution imaging technique that is increasingly used for intracoronary imaging to characterize coronary atherosclerotic plaques and vascular responses after coronary stent implantation. Introduction of optical frequency-domain imaging (OFDI; second generation OCT) has simplified practical use of this novel imaging modality resulting in a more widespread availability in interventional cardiology. Here we highlight recent insights into the acute and chronic vascular response after coronary stent implantation by OCT imaging. OCT provides cross-sectional images with approximately 10-fold higher resolution as compared to intravascular-ultrasound (IVUS), allowing for precise evaluation of tissue coverage and malapposition of coronary stent ...

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    1-14 of 14
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    Optical Coherence Tomography Imaging: Novel Insights into the Vascular Response After Coronary Stent Implantation Optical coherence tomography to reveal strut malapposition due to thrombus resolution 3 weeks after acute coronary syndrome Vascular lesions induced by renal nerve ablation as assessed by optical coherence tomography: pre- and post-procedural comparison with the Simplicity® catheter system and the EnligHTN™ multi-electrode renal denervation catheter Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation Optical coherence tomography to reveal vascular lesions after catheter-based renal nerve ablation with a novel multi-electrode EnligHTNTM system Impact of local vascular lesions assessed with optical coherence tomography and ablation points on blood pressure reduction after renal denervation Optical coherence tomography imaging after successful percutaneous coronary intervention treatment of coronary perforation following bioabsorbable vascular scaffold implantation: Consecutive ping-pong and child-in-mother techniques The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical Bas-relief in three dimensional optical coherence tomography: a novel sign after subintimal scaffolding in a chronic total occlusion Implantation of bioresorbable scaffolds under guidance of optical coherence tomography: feasibility and pilot clinical results of a systematic protocol SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study A Deep Learning Approach in Rebubbling After Descemet's Membrane Endothelial Keratoplasty