1. Articles from Mark A. Randolph

    1-2 of 2
    1. In vivo optical microscopy of peripheral nerve myelination with polarization sensitive-optical coherence tomography

      In vivo optical microscopy of peripheral nerve myelination with polarization sensitive-optical coherence tomography

      Assessing nerve integrity and myelination after injury is necessary to provide insight for treatment strategies aimed at restoring neuromuscular function. Currently, this is largely done with electrical analysis, which lacks direct quantitative information. In vivo optical imaging with sufficient imaging depth and resolution could be used to assess the nerve microarchitecture. In this study, we examine the use of polarization sensitive-optical coherence tomography (PS-OCT) to quantitatively assess the sciatic nerve microenvironment through measurements of birefringence after applying a nerve crush injury in a rat model. Initial loss of function and subsequent recovery were demonstrated by calculating the sciatic function index ...

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    2. Extracting structural features of rat sciatic nerve using polarization-sensitive spectral domain optical coherence tomography

      Extracting structural features of rat sciatic nerve using polarization-sensitive spectral domain optical coherence tomography

      We present spectral domain polarization-sensitive optical coherence tomography (SD PS-OCT) imaging of peripheral nerves. Structural and polarization-sensitive OCT imaging of uninjured rat sciatic nerves was evaluated both qualitatively and quantitatively. OCT and its functional extension, PS-OCT, were used to image sciatic nerve structure with clear delineation of the nerve boundaries to muscle and adipose tissues. A long-known optical effect, bands of Fontana, was also observed. Postprocessing analysis of these images provided significant quantitative information, such as epineurium thickness, estimates of extinction coefficient and birefringence of nerve and muscle tissue, frequency of bands of Fontana at different stretch levels of nerve ...

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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) Massachusetts General Hospital
    2. (2 articles) UC Riverside
    3. (2 articles) VU University Amsterdam
    4. (2 articles) B. Hyle Park
    5. (2 articles) Yan Wang
    6. (2 articles) Johannes F. de Boer
    7. (1 articles) Harvard University
    8. (1 articles) M. Shahidul Islam
    9. (1 articles) Multiwave Photonics
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