1. Articles from Eugénie Dalimier

    1-11 of 11
    1. In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography

      In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography

      Despite obvious improvements in visualization of the in vivo cornea through the faster imaging speeds and higher axial resolutions, cellular imaging stays unresolvable task for OCT, as en face viewing with a high lateral resolution is required. The latter is possible with FFOCT, a method that relies on a camera, moderate numerical aperture (NA) objectives and an incoherent light source to provide en face images with a micrometer-level resolution. Recently, we for the first time demonstrated the ability of FFOCT to capture images from the in vivo human cornea1. In the current paper we present an extensive study of appearance ...

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    2. In vivo high resolution human corneal imaging using full-field optical coherence tomography

      In vivo high resolution human corneal imaging using full-field optical coherence tomography

      We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowman’s layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemet’s membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 µm and relatively large field-of-view of 1.26 mm x 1.26 mm – a combination, which, to the best of our knowledge, has not been possible with other in vivo human eye imaging methods. The latter together with a contactless ...

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    3. Real-time cancer diagnosis during prostate biopsy: ex vivo evaluation of full-field optical coherence tomography (FFOCT) imaging on biopsy cores

      Real-time cancer diagnosis during prostate biopsy: ex vivo evaluation of full-field optical coherence tomography (FFOCT) imaging on biopsy cores

      Objectives To evaluate the diagnostic accuracy (Acc) of full-field optical coherence tomography (FFOCT) for cancer detection on prostate biopsy. Materials and methods Thirty-eight consecutive patients with elevated PSA and/or suspicious digital rectal examination were prospectively included. For each patient, 1–10 cores were randomly selected and imaged with FFOCT immediately after sampling. The images obtained were de-identified and analyzed by three pathologists blinded to the results of pathological evaluation. The overall average Acc was measured, as well as sensitivity (Se), specificity (Sp), positive and negative predictive values (PPV and NPV). The Acc learning curve was assessed by multivariate logistic ...

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    4. Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography

      Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography

      Current techniques for the intraoperative analysis of sentinel lymph nodes during breast cancer surgery present drawbacks such as time and tissue consumption. Full-field optical coherence tomography is a novel noninvasive, high-resolution, fast imaging technique. This study investigated the use of full-field optical coherence tomography as an alternative technique for the intraoperative analysis of sentinel lymph nodes. Seventy-one axillary lymph nodes from 38 patients at Tenon Hospital were imaged minutes after excision with full-field optical coherence tomography in the pathology laboratory, before being handled for histological analysis. A pathologist performed a blind diagnosis (benign/malignant), based on the full-field optical coherence ...

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    5. Full-field optical coherence tomography (FFOCT) for evaluation of endometrial cancer

      Full-field optical coherence tomography (FFOCT) for evaluation of endometrial cancer

      Full-field optical coherence tomography (FFOCT) quickly produces images that resemble conventional pathology images. We examined endometrium in an intra-operative like fashion (more than forty samples). FFOCT-imaged endometrium was recognizable to pathologists and compared favorably with microscopy of the same samples. Additional image enhancements and acquisition techniques were explored and may improve interpretation accuracy. Wider evaluation of images is ongoing, using more pathologist subjects. FFOCT may revolutionize pathology practice in the future by permitting rapid diagnosis and in vivo diagnosis; this is potentially a disruptive new diagnostic technique in pathology.

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    6. A feasibility study of full-field optical coherence tomography for rapid evaluation of EUS-guided microbiopsy specimens

      A feasibility study of full-field optical coherence tomography for rapid evaluation of EUS-guided microbiopsy specimens

      Background Rapid on-site evaluation of cytologic specimens is a way of determining the adequacy of fine-needle aspiration (FNA). However, alternatives may be useful when the presence of a cytotechnologist and/or pathologist is not possible. Objective To evaluate the feasibility of using full-field optical coherence tomography (FFOCT) for FNA specimen quality assessment. Design FFOCT images were acquired on gastric, pancreatic, pelvic, and lymph-node formalin-fixed FNA specimens and were compared with histology of the same samples. Setting Pathology suite in a hospital. Patients Fourteen patients undergoing gastric, pancreatic, pelvic, or lymph-node EUS-guided FNA biopsy. Interventions FFOCT imaging on formalin-fixed samples before ...

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    7. En-face full-field optical coherence tomography for fast and efficient fingerprints acquisition

      En-face full-field optical coherence tomography for fast and efficient fingerprints acquisition

      Optical coherence tomography (OCT) has been recently proposed by a number of laboratories as a promising tool for fingerprints acquisitions and for fakes discrimination. Indeed OCT being a non-contact, non-destructive optical method that virtually sections the volume of biological tissues that strongly scatter light it appears obvious to use it for fingerprints. Nevertheless most of the OCT setups have to go through the long acquisition of a full 3D image to isolate an “en-face” image suitable for fingerprint analysis. A few “en-face” OCT approaches have been proposed that use either a complex 2D scanning setup and image processing, or a ...

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    8. Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-clinical Study of Human Breast Tissue and Cancer Assessment

      Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-clinical Study of Human Breast Tissue and Cancer Assessment

      We present a benchmark pilot study in which high-resolution Full-Field Optical Coherence Tomography (FF-OCT) was used to image human breast tissue and is evaluated to assess its ability to aid the pathologist’s management of intra-operative diagnoses. FF-OCT imaging safety was investigated and agreement between FF-OCT and routinely prepared histopathological images was evaluated. The compact setup used for this study provides 1 mm3 resolution and 200 mm imaging depth, and a 2.25 cm2 specimen is scanned in about 7 minutes. 75 breast specimens were imaged from 22 patients (21 women, 1 man) with a mean age of 58 (range ...

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    9. Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging

      Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging

      Background/Aims: Full-field optical coherence tomography (FFOCT) is a new imaging technology that can provide 3D micron-level resolution and is suited for high-resolution imaging of biological tissue. The aim of this study was to evaluate its capacity and potential for imaging human epidermis and dermis and various skin pathologies in ex vivo and in vivo conditions. Methods: Non-fixed and fixed samples of normal and pathological skin and normal in vivo skin were imaged with a FFOCT system and compared to histological slides. Results: The epidermis and adnexae, the collagen bundles of the dermis and the hypodermis could be identified through ...

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    10. Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging

      Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging

      Background/Aims : Full-field optical coherence tomography (FFOCT) is a new imaging technology that can provide 3D micron-level resolution and is suited for high resolution imaging of biological tissue. The aim of this study is to evaluate its capacity and potential for imaging human epidermis and dermis and various skin pathologies in ex- and in-vivo conditions. Methods : Non fixed and fixed samples of normal and pathological skin and normal in-vivo skin were imaged with a FFOCT system and compared to histological slides. Results: The epidermis and adnexae, the collagen bundles of the dermis and the hypodermis could be identified through architectural ...

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    1-11 of 11
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    1. (11 articles) Eugénie Dalimier
    2. (9 articles) LLTech
    3. (5 articles) Claude Boccara
    4. (5 articles) Kate Grieve
    5. (4 articles) ESPCI ParisTech
    6. (4 articles) Fabrice Harms
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    Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-clinical Study of Human Breast Tissue and Cancer Assessment En-face full-field optical coherence tomography for fast and efficient fingerprints acquisition A feasibility study of full-field optical coherence tomography for rapid evaluation of EUS-guided microbiopsy specimens Full-field optical coherence tomography (FFOCT) for evaluation of endometrial cancer Assessment of Sentinel Node Biopsies With Full-Field Optical Coherence Tomography Real-time cancer diagnosis during prostate biopsy: ex vivo evaluation of full-field optical coherence tomography (FFOCT) imaging on biopsy cores In vivo high resolution human corneal imaging using full-field optical coherence tomography In vivo imaging through the entire thickness of human cornea by full-field optical coherence tomography Postdoctoral Associate Position at Duke Vision and Image Processing Laborator Anterior segment optical coherence tomography angiography