1. Articles from Daisuke Yokota

    1-5 of 5
    1. Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe

      Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe

      Although lipid lowering therapy by statin and ezetimibe has been reported to provide greater reduction in low-density lipoprotein cholesterol (LDL-C) levels than statin monotherapy, the effect of supplemental therapy on plaque stabilization is yet to be fully elucidated. Cap thickness of fibroatheroma evaluated by Optical coherence tomography (OCT) is a major determinant of vulnerable plaque. The primary objective of this study is to evaluate the effect of ezetimibe in addition to fluvastatin on progression of coronary atherosclerotic plaque evaluated by OCT. Sixty-three angina pectoris patients with intermediate, non-culprit, lipid-rich plaque lesions evaluated by OCT were enrolled. The patients were divided ...

      Read Full Article
    2. Impact of Cholesterol Metabolism on Coronary Plaque Vulnerability of Target Vessels : A Combined Analysis of Virtual Histology Intravascular Ultrasound and Optical Coherence Tomography

      Impact of Cholesterol Metabolism on Coronary Plaque Vulnerability of Target Vessels : A Combined Analysis of Virtual Histology Intravascular Ultrasound and Optical Coherence Tomography

      Objectives The aim of this study was to evaluate the relationship between cholesterol metabolism and coronary plaque vulnerability. Background Cholesterol homeostasis, defined as the balance between absorption and synthesis, influences the progression of coronary atherosclerosis. Methods Consecutive stable angina pectoris patients (N = 80) not receiving any lipid-lowering therapy were divided into 2 groups based on the presence of in vivo thin cap fibroatheroma (TCFA) in de novo target vessels assessed by the combined use of virtual histology intravascular ultrasound and optical coherence tomography. Results Patients with in vivo TCFA (n = 42) showed a higher campesterol-to-lathosterol ratio (3.36 [interquartile range ...

      Read Full Article
    3. Morphological differences of tissue characteristics between early, late, and very late restenosis lesions after first generation drug-eluting stent implantation: an optical coherence tomography study

      Morphological differences of tissue characteristics between early, late, and very late restenosis lesions after first generation drug-eluting stent implantation: an optical coherence tomography study

      Aims Restenosis of drug-eluting stents (DESs) might be different from that of bare metal stent restenosis in diverse ways including mechanisms and time course; however, these have not been fully examined. To gain insight into the mechanisms and time course of DES restenosis, we evaluated the characteristics of restenotic lesions of first generation DES using optical coherence tomography (OCT). Methods and results We compared the morphological characteristics of early in-stent restenosis (<1 year: E-ISR, n = 43), late ISR (1–3 years: L-ISR, n = 22), and very late ISR (>3 years: VL-ISR, n = 21). OCT qualitative restenotic tissue analysis included the ...

      Read Full Article
    4. Response to Letter Regarding Article, "Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance"

      Response to Letter Regarding Article, "Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance"

      We appreciate the valuable comments by Garcia-Garcia et al regarding our article.1 We agree with the comments on our limitations about study design especially with regard to criteria of the procedure. First, the efficacy of distal protection devices in native coronary arteries is still controversial, and criteria regarding usage of this device are not defined yet. However, we believe this device could be helpful for prevention of distal embolus in certain cases as we have sometimes experienced, and optical frequency-domain imaging (OFDI) is helpful to predict such cases. Making use of the criteria of this study, distal protection was ...

      Read Full Article
    5. Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance

      Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance

      Background—Frequency-domain optical coherence tomography (FD-OCT) is a novel, high resolution intravascular imaging modality. Intravascular ultrasound (IVUS) is a widely used conventional imaging modality for achieving optimal stent deployment. The aim of this study was to evaluate the impact of FD-OCT guidance for coronary stent implantation compared with IVUS guidance. Methods and Results—A total of 70 patients with de novo coronary artery lesions and either unstable or stable angina pectoris were enrolled in this randomized study (optical coherence tomography [OCT] group: n=35, IVUS group: n=35). In the OCT group, stent implantation was performed under FD-OCT guidance alone ...

      Read Full Article
    1-5 of 5
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (5 articles) Toyohashi Heart Center
    2. (5 articles) Etsuo Tsuchikane
    3. (5 articles) Masashi Kimura
    4. (5 articles) Mitsuyasu Terashima
    5. (5 articles) Takahiko Suzuki
    6. (4 articles) Tsuyoshi Ito
    7. (4 articles) Yoshihisa Kinoshita
    8. (4 articles) Kenya Nasu
    9. (4 articles) Maoto Habara
    10. (2 articles) Osamu Katoh
    11. (1 articles) FDA
    12. (1 articles) Rice University
    13. (1 articles) Case Western Reserve University
    14. (1 articles) Anant Agrawal
    15. (1 articles) Patrick W. Serruys
    16. (1 articles) Hector M. Garcia-Garcia
    17. (1 articles) Stephan Windecker
    18. (1 articles) Daniel X. Hammer
    19. (1 articles) Justis P. Ehlers
    20. (1 articles) Maciej Wojtkowski
  3. Popular Articles

  4. Picture Gallery

    Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance Response to Letter Regarding Article, "Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance" Morphological differences of tissue characteristics between early, late, and very late restenosis lesions after first generation drug-eluting stent implantation: an optical coherence tomography study Impact of Cholesterol Metabolism on Coronary Plaque Vulnerability of Target Vessels : A Combined Analysis of Virtual Histology Intravascular Ultrasound and Optical Coherence Tomography Impact on Optical Coherence Tomographic Coronary Findings of Fluvastatin Alone versus Fluvastatin+ Ezetimibe Research Engineer/Software Programmer Position at Doheny Eye Institute UCLA Microscopic OCT imaging with focus extension by ultrahigh-speed acousto-optic tunable lens and stroboscopic illumination The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina Management of intrastromal glass foreign body based on anterior segment optical coherence tomography and Pentacam analysis Pulmonary vein stenosis after radiofrequency ablation: in vivo optical coherence tomography insights Utilization of Peripheral Optical Coherence Tomography to Optimize Diagnosis of a Vortex Vein Varix Spectral Domain OCT Imaging Techniques in Tamoxifen Retinopathy