1. Articles from Kouros Nouri-Mahdavi

    1-13 of 13
    1. Macular Imaging with Optical Coherence Tomography in Glaucoma

      Macular Imaging with Optical Coherence Tomography in Glaucoma

      With the advent of spectral-domain optical coherence tomography (SD-OCT), imaging of the posterior segment of the eye can be carried out rapidly at multiple anatomical locations, including the optic nerve head (ONH), circumpapillary retinal nerve fiber layer (cp-RNFL), and macula. There is now ample evidence to support the role of SD-OCT imaging of the macula for detection of early glaucoma. Macular SD-OCT measurements demonstrate high reproducibility, and evidence on its utility for detection of glaucoma progression is accumulating. We present a comprehensive review of macular SD-OCT imaging emerging as an essential diagnostic tool in glaucoma.

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    2. Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters

      Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters

      Purpose To test the hypothesis that baseline optical coherence tomography (OCT) measures predict visual field (VF) progression in a cohort of patients with suspected or established glaucoma and compare their performance to semiquantitative optic disc measures. Design Observational cohort study. Methods Setting: Academic institution. Study Population One-hundred seventy-one eyes of 95 patients with good-quality baseline retinal nerve fiber layer (RNFL) and macular OCT images and disc photographs with >2 years of follow-up and ≥5 VFs. Observation Procedures Baseline macular and RNFL OCT measures and cup-to-disc ratio and disc damage likelihood score. Main Outcome Measures Prediction of glaucomatous visual field deterioration ...

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    3. Swept-Source Optical Coherence Tomography for Evaluating the Lamina Cribrosa A Report by the American Academy of Ophthalmology

      Swept-Source Optical Coherence Tomography for Evaluating the Lamina Cribrosa A Report by the American Academy of Ophthalmology

      Objective To review the published literature on the use of swept-source optical coherence tomography (SS-OCT) for evaluating the lamina cribrosa in glaucoma. Methods A PubMed and Cochrane Library literature search initially conducted on March 3, 2017 and updated on June 26, 2018 yielded a total of 64 articles. Articles that were reviews or that were not published in English were excluded, and 29 were found to fit the inclusion criteria. The panel methodologist then assigned a level of evidence rating to each study. Fifteen studies were rated level III, 14 studies were rated level II, and no studies were rated ...

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    4. Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography

      Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography

      Purpose To compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes. Methods Cross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms. Systemic differences, diagnostic properties, reliability, and agreement of the methods were investigated. Results Healthy eyes exhibited higher vessel density values in all ...

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    5. Optical Coherence Tomography in Glaucoma: A Practical Guide (Textbook)

      Optical Coherence Tomography in Glaucoma: A Practical Guide (Textbook)

      This book focuses on the practical aspects of Optical Coherence Tomography (OCT) in glaucoma diagnostics offering important theoretical information along with many original cases. OCT is a non-invasive imaging technique that acquires high-resolution images of the ocular structures. It enables clinicians to detect glaucoma in the early stages and efficiently monitor the disease. Optical Coherence Tomography in Glaucoma features updated information on technical applications of OCT in glaucoma, reviews recently published literature and provides clinical cases based on Cirrus and Spectralis OCT platforms. In addition, newer techniques like event and trend analyses for progression, macular ganglion cell analysis, and OCT ...

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      Mentions: UCLA
    6. Comparison of macular choroidal thickness in patients with pseudoexfoliation syndrome to normal control subjects with enhanced-depth SD-OCT imaging

      Comparison of macular choroidal thickness in patients with pseudoexfoliation syndrome to normal control subjects with enhanced-depth SD-OCT imaging

      Purpose To test the hypothesis that macular choroidal thickness is lower in patients with pseudoexfoliation syndrome (PXS) as compared to healthy control subjects. Methods In this cross-sectional, observational study, 38 non-glaucomatous PXS subjects and 37 healthy volunteers were enrolled in a tertiary care Glaucoma Clinic. The macular region was scanned with the enhanced depth imaging (EDI) protocol of a spectral domain optical coherence tomography (SD-OCT) device (Spectralis OCT, Heidelberg Engineering, Heidelberg, Germany). Macular choroidal thickness and volumes were compared in nine sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) layout profile across the central 3.45 mm zone after ...

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    7. Optical coherence tomography angiography: A new tool in glaucoma diagnostics and research

      Optical coherence tomography angiography: A new tool in glaucoma diagnostics and research

      Optical coherence tomography angiography (OCTA) is a new modality in ocular imaging which provides high resolution view of the vascular structures in the retina and optic nerve head. This technology has the advantages of being noninvasive, rapid and reproducible. OCTA is becoming a valuable tool for evaluating many retinal and optic nerve diseases. This article provides a brief introduction to the technology and its application in the field of glaucoma diagnostics.

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      Mentions: UCLA
    8. Anterior segment optical coherence tomography in subtypes of angle closure glaucoma

      Anterior segment optical coherence tomography in subtypes of angle closure glaucoma

      Primary angle-closure glaucoma (ACG) is a serious ocular health care problem especially in Asia, increasing in prevalence as one moves towards the Eastern part of Asia. 1 The disease causes a significant burden of blindness and visual disability in regions where it is most prevalent. With the advent of SD-OCTs, anterior and posterior segment mechanisms of the disease have been better elucidated. However, like primary open-angle glaucoma, ACG likely represents different phenotypes yet to be identified through research on the genetics. In the meantime, significant amount of ongoing research is devoted to better understanding the contribution of various well-defined mechanisms ...

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      Mentions: UCLA
    9. Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance

      Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance

      Purpose: To analyze the influence of ocular magnification on the peripapillary retinal nerve fiber layer (RNFL) thickness measurement and its performance as acquired with spectral-domain optical coherence tomography (SD-OCT). Methods: SD-OCT measurements from 108 normal eyes (59 subjects) and 72 glaucoma eyes (58 patients) were exported and custom software was used to correct RNFL measurements for ocular magnification. RNFL prediction limits in normal subjects, structure-function relationships, and RNFL performance for detection of glaucoma were compared before and after correction for ocular magnification (Bennett's formula). Association of disc area with cross-sectional RNFL area was explored. Results: The median (interquartile range ...

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    10. Measurement of the Optic Disc Vertical Tilt Angle With Spectral-Domain Optical Coherence Tomography and Influencing Factors

      Measurement of the Optic Disc Vertical Tilt Angle With Spectral-Domain Optical Coherence Tomography and Influencing Factors

      Purpose To report a novel method for measuring the vertical tilt angle of the optic nerve (ON) head and to investigate the associated factors. Design Cross-sectional diagnostic study. Methods One hundred and twelve normal, glaucomatous, and glaucoma suspect eyes (99 patients) were enrolled in this study. Subjects underwent a full eye examination, biometry, and spectral-domain optical coherence tomography (SDOCT). The vertical tilt angle was measured on high-resolution cross-sectional SDOCT images passing through the ON head and foveal centers using the inner edges of the Bruch membrane opening as the reference plane. The correlation between the vertical tilt angle with the ...

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    11. Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy

      Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy

      Purpose: To compare optic disc and neuroretinal rim area measurements from spectral-domain optical coherence tomography (SD-OCT) to those from confocal scanning laser ophthalmoscopy. Methods: Seventy-one eyes from 43 normal subjects or suspected/definite glaucoma patients were prospectively enrolled. All subjects had biometry with the IOLMaster and disc/retinal nerve fiber layer (RNFL) imaging with Cirrus SD-OCT (Optic Disc Cube 200x200) and Heidelberg Retina Tomograph (HRT). Keratometry-corrected (K-corrected) HRT measurements and uncorrected Cirrus disc and rim areas and disc measurements corrected for eye magnification with Bennett's formula (AL-corrected) along with 30-degree sectoral rim areas, vertical cup-to-disc ratio (VCDR), and cup ...

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    12. Structure-Function Relationships between Spectral-Domain OCT and Standard Achromatic Perimetry

      Structure-Function Relationships between Spectral-Domain OCT and Standard Achromatic Perimetry

      Purpose: To explore structure-function relationships in early glaucoma with spectral-domain optical coherence tomography (SD-OCT) and standard achromatic perimetry. Methods: One hundred thirty-six eyes of 97 patients with suspected or early glaucoma were enrolled from the clinical database at UCLA's Glaucoma Division. All patients had good-quality peripapillary retinal nerve fiber layer (RNFL)/optic disc measurements (Optic Disc Cube 200x200, Cirrus HD-OCT) and a reliable 24-2 SITA-Standard Humphrey visual field (VF) within a 6-month period. Correlations of global and sectoral RNFL thickness and rim area (RA) measurements with corresponding global and regional VF sensitivities (both in logarithmic [dB] and 1/Lambert ...

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    1-13 of 13
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    1. (7 articles) UCLA
    2. (5 articles) Joseph Caprioli
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    Structure-Function Relationships between Spectral-Domain OCT and Standard Achromatic Perimetry Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy Measurement of the Optic Disc Vertical Tilt Angle With Spectral-Domain Optical Coherence Tomography and Influencing Factors Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance Optic Nerve Head and RNFL Imaging: Comparison of Technologies (Book Chapter) Anterior segment optical coherence tomography in subtypes of angle closure glaucoma Optical coherence tomography angiography: A new tool in glaucoma diagnostics and research Comparison of macular choroidal thickness in patients with pseudoexfoliation syndrome to normal control subjects with enhanced-depth SD-OCT imaging Optical Coherence Tomography in Glaucoma: A Practical Guide (Textbook) Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters Nonculprit Lesion Plaque Morphology in Patients With ST-Segment–Elevation Myocardial Infarction: Results From the COMPLETE Trial Optical Coherence Tomography Substudys Are choriocapillaris flow void features robust to diurnal variations? A swept-source optical coherence tomography angiography (OCTA) study