All Articles from Jun Zhang -Optical Coherence Tomography News

Articles from Jun Zhang

1-24 of 48 1 2 »
1. Balanced detection spectral-domain optical coherence tomography with a single line-scan camera
  
  Explore OSA | OSA Publishing Jan 19 2022
  
  This paper describes a balanced detection spectral-domain optical coherence tomography (BD-SD-OCT) system for suppressing autocorrelation (AC) artifacts and increasing the signal-to-noise ratio (SNR). The system employed three optical fiber couplers to generate two phase-opposed interference spectra that were acquired by a single line-scan camera simultaneously. When compared with conventional unbalanced detection SD-OCT systems, the developed BD-SD-OCT system improved the SNR by 5.4-6 dB and suppressed the AC term by 5-10 dB. The imaging quality of the BD-SD-OCT system was evaluated by in vivo imaging of human nail folds and retinas.
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  Mentions: Sun Yat-Sen University
2. Identification of oral precancerous and cancerous tissue by swept source optical coherence tomography
  
  Explore Wiley Online Library Aug 4 2021 Oncology
  
  Background and objectives: Distinguishing cancer from precancerous lesions is critical and challenging in oral medicine. As a noninvasive method, optical coherence tomography (OCT) has the advantages of real-time, in vivo, and large-depth imaging. Texture information hidden in OCT images can provide an important auxiliary effect for improving diagnostic accuracy. The aim of this study is to explore a reliable and accurate OCT-based method for the screening and diagnosis of human oral diseases, especially oral cancer. Materials and methods: Fresh ex vivo oral tissues including normal mucosa, leukoplakia with epithelial hyperplasia (LEH), and oral squamous cell carcinoma (OSCC) were imaged intraoperatively ...
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  Mentions: Nankai University
3. Classification of oral salivary gland tumors based on texture features in optical coherence tomography images
  
  Explore Home - Springer Jun 30 2021
  
  Currently, the diagnoses of oral diseases primarily depend on the visual recognition of experienced clinicians. It has been proven that automatic recognition based on images can support clinical decision-making by extracting and analyzing objective hidden information. In recent years, optical coherence tomography (OCT) has become a powerful optical imaging technique with the advantages of high resolution and non-invasion. In our study, a dataset composed of four kinds of oral salivary gland tumors (SGTs) was obtained from a homemade swept-source OCT, including two benign and two malignant tumors. Seventy-six texture features were extracted from OCT images to create computational models of ...
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  Mentions: Nankai University
4. Classification of Salivary Gland Tumors Based on Quantitative Optical Coherence Tomography
  
  Explore Wiley Online Library Jan 16 2021
  
  Background and Objectives Visual inspection is the primary diagnostic method for oral diseases, and its accuracy of diagnosis mainly depends on surgeons’ experience. Histological examination is still the golden standard, but it is invasive and time‐consuming. In order to address these issues, as a noninvasive imaging technique, optical coherence tomography (OCT) can differentiate oral tissue with advantages of real‐time, in situ , and high resolution. The aim of this study is to explore optimal quantitative parameters in OCT images to distinguish different salivary gland tumors. Study Design/Materials and Methods OCT images of four salivary gland tumors were obtained ...
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  Mentions: Nankai University
5. The vessel density of the superficial retinal capillary plexus as a new biomarker in cerebral small vessel disease: an optical coherence tomography angiography study
  
  Explore Home - Springer Jan 13 2021 Cardiology
  
  Background: Optical coherence tomography angiography (OCTA) is a novel and noninvasive technique for the quantitative assessment of retinal microvascular perfusion. Since the retinal and cerebral small vessels share similar embryological origins, anatomical features, and physiological properties, altered retinal microvasculature might provide a new perspective on the mechanisms of cerebral small vessel disease (CSVD). Objective: We aimed to evaluate retinal vessel density (VD) in patients with CSVD using OCTA and identify associations with cerebral magnetic resonance imaging (MRI) markers and cognitive function. Methods: We prospectively recruited 47 CSVD patients and 30 healthy controls (HCs) to participate in the study. All participants ...
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6. Dynamic-range compression and contrast enhancement in swept-source optical coherence tomography systems with a frequency gain compensation amplifier
  
  Explore SPIE Digital Library Nov 29 2020
  
  Significance: Optical coherence tomography (OCT) has been widely used in clinical studies. However, the image quality of OCT decreases with increasing imaging depth since the light is rapidly attenuated in biological tissues. Aim: We present a compensation approach to preserve weak high-frequency signals from deep structures and compress the dynamic range of the detected signal for superior analog-to-digital conversion and image display capability. Approach: A homemade frequency gain compensation amplifier is designed and fabricated to amplify the electrical signal from a balanced photodetector and compensate for the signal attenuation in swept-source OCT (SSOCT). Results: It is demonstrated in imaging various ...
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  Mentions: Sun Yat-Sen University
7. Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment
  
  Explore MDPI Open Access Journals Platform Oct 25 2020 Otolaryngology
  
  Laryngeal lesions can cause great inconvenience to patients. Early diagnosis and corresponding treatments are critical to the survival of patients. However, the diagnosis and precise removal of tumors remain a challenge under the use of a white light laryngoscope. In this work, an integrated, multifunctional laryngoscope was designed and tested for the imaging evaluation and precision laser surgery for laryngeal tissue. This integrated diagnostic and therapeutic endoscopic system included two imaging modes (i.e., optical coherence tomography and white light endoscopy) and a laser ablation treatment mode. The endoscope had a common-path design to ensure that the same position could ...
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  Mentions: Sun Yat-Sen University
8. Identification of oral cancer in OCT images based on an optical attenuation model
  
  Explore Home - Springer Apr 30 2020
  
  Surgery is still the first choice to treat oral cancer, where it is important to detect surgical margins in order to reduce cancer recurrence and maintain oral-maxillofacial function simultaneously. As a non-invasive and in situ imaging technique, optical coherence tomography (OCT) can obtain images close to the resolution of histopathology, which makes it have great potential in intraoperative diagnosis. However, it is not enough to find surgical margins accurately just observing OCT images directly and qualitatively. The purpose of this study is to identify oral cancer in OCT images by investigating the quantitative difference of cancer and non-cancer tissue. Based ...
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  Mentions: Nankai University
9. Multi-modal Anterior Eye Imager Combining Ultra-High Resolution OCT and Microvascular Imaging for Structural and Functional Evaluation of the Human Eye
  
  Explore MDPI Open Access Journals Platform Apr 12 2020 Ophthalmology
  
  To establish complementary information for the diagnosis and evaluation of ocular surface diseases, we developed a multi-modal, non-invasive optical imaging platform by combining ultra-high resolution optical coherence tomography (UHR-OCT) with a microvascular imaging system based on slit-lamp biomicroscopy. Our customized UHR-OCT module achieves an axial resolution of ≈2.9 μm in corneal tissue with a broadband light source and an A-line acquisition rate of 24 kHz with a line array CCD camera. The microvascular imaging module has a lateral resolution of 3.5 μm under maximum magnification of ≈187.5× with an imaging rate of 60 frames/s, which is ...
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  Mentions: Sun Yat-Sen University
10. Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography
  
  Explore insights.ovid.com Jun 24 2019 Gastroenterology
  
  INTRODUCTION: “ Resectanddiscard ” paradigmisoneofthemainstrategiestodealwithcolorectaldiminutivepolyps after optical diagnosis. However, there are risks that unrecognized potentially malignant lesions are discarded without accurate diagnosis. The purpose of this study is to validate the potential of micro- optical coherence tomography ( m OCT) to improve the diagnostic accuracy of colorectal lesions and help endoscopists make better clinical decision without additional pathology costs. METHODS: RESULTS: DISCUSSION: Fresh tissue samples were obtained from patients with colorectal polyps or colorectal cancer who received endoscopic therapy or laparoscopic surgery. These samples were instantly imaged by m OCT and then sent to pathological evaluation. Then, m OCT images were compared with ...
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  Mentions: Nanyang Technological University
11. Correction of saturation effects in endoscopic swept-source optical coherence tomography based on dual-channel detection
  
  Explore SPIE Digital Library Mar 7 2018
  
  Saturation artifacts that are commonly observed in endoscopic swept-source optical coherence tomography (SSOCT) images cause image degradation and loss of image information. We present work on the correction of saturation effects in endoscopic SSOCT imaging. This method utilizes a broadband power divider with excellent pick-off flatness to divide the detected interference signal into the two channels of an analog-to-digital converter. Based on the precise calibration of the splitting ratio between the two channels, the maximum measurable signal power of the system was drastically increased by using the low level signal in one channel to correct the saturated signal in the ...
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  Mentions: Sun Yat-Sen University
12. Dynamically focused optical coherence tomography for endoscopic applications
  
  Explore aip.scitation.org Apr 12 2017 Gastroenterology
  
  We report a demonstration of a small liquid-filled polymer lens that may be used to dynamically provide scanning depth focus for endoscopic optical coherence tomography (OCT) applications. The focal depth of the lens is controlled by changing the hydraulic pressure within the lens, enabling dynamic focal depth control without the need for articulated parts. The 1 mm diameter lens is shown to have resolving power of 5 μm, and can enable depth scans of 2.5 mm, making it suitable for use with OCT-enabled optical biopsy applications.
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  Mentions: UC Irvine
13. Contrast improvement for swept source optical coherence tomography image of sub-surface tissue
  
  Explore Conference Proceedings Mar 1 2017
  
  Swept source optical coherence tomography (SSOCT) is an attractive biological imaging technology due to its advantages of simple setup and high imaging speed. As the light intensity attenuated rapidly in high scattering biological tissues, the contrast of OCT image will drop with depth. In this paper a new method was introduced to compensate the attenuation of imaging contrast in SSOCT. The interference signal was divided into two channels of analog to digital converter (ADC) with a splitting ratio of 1:5. The higher level signal in one channel was used to reconstruct deeper structure of tissue and the lower level ...
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  Mentions: Sun Yat-Sen University
14. Suppression of saturation artifacts in swept source optical coherence tomography using dual channel detection
  
  Explore Conference Proceedings Mar 15 2016
  
  A technique to suppress saturation artifacts in swept source optical coherence tomography (SSOCT) system was presented. The detected signal was split into two channels of a high speed data acquisition card with two levels by a power divider. The signal in one channel with higher level was used to reconstruct OCT images and the signal in the other channel with lower level was used to compensate the saturated signal in the first channel by calibrating the splitting ratio between the two channels. Based on dual channel detection, this technique can enhance the dynamic range of SSOCT system and remove saturation ...
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  Mentions: Sun Yat-Sen University
15. Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging
  
  Explore opticsinfobase.org Nov 19 2014 Cardiology , Probes
  
  In this Letter, we present a trimodality imaging system and an intravascular endoscopic probe for the detection of early-stage atherosclerotic plaques. The integrated system is able to acquire optical coherence tomography (OCT), fluorescence, and ultrasound images and simultaneously display them in real time. A trimodality intravascular endoscopic probe of 1.2 mm in diameter and 7 mm in length was fabricated based on a dual-modality optical probe that integrates OCT and fluorescence imaging functions and a miniature ultrasound transducer. The probe is capable of rotating at up to 600 rpm. Ex vivo images from rabbit aorta and human coronary arteries ...
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  Mentions: University of Southern California
16. Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis
  
  Explore imaging.onlinejacc.org Jan 19 2014 Cardiology
  
  Accurate assessment of atherosclerotic plaque characteristics and the subsequent tailoring of optimal therapy holds great promise for preventing acute coronary syndromes (ACS) and life-threatening sequelae 1 . Combined use of optical coherence tomography (OCT) and intravascular ultrasound (IVUS) was proposed as a potential method for accurate assessment of plaque characteristics and vulnerability ( 2 , ). However, significant challenges remain in trying to adapt an integrated OCT-IVUS system for clinical applications. We report here a fully integrated intracoronary OCT-IVUS imaging technique to visualize atherosclerotic plaque in living animals and human coronary arteries from cadavers with high resolution and deep penetration capability simultaneously.
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  Mentions: University of Southern California UC Irvine
17. Feature Of The Week 11/24/13 : Miniature OCT/IVUS probe for automatically co-registered three-dimensional intracoronary imaging with real-time display
  
  Explore Optical Coherence Tomography News Nov 24 2013 Cardiology , Probes
  
  Combined use of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) holds the potential of combining the strengths of both imaging modalities and improving the diagnostic accuracy of atherosclerotic plaque vulnerability. In this manuscript, we reported a co-registered intracoronary OCT-IVUS system and catheter with real-time imaging and polar-coordinate displaying capability, well-suited for clinical utilization in guiding interventional cardiologists. With an eventual goal of clinical use in humans, this novel catheter design and modified software are poised to strengthen the ability to diagnose vulnerable plaques in patients in real-time. We upgraded our old designs in the following aspects. 1) This novel ...
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  Mentions: University of Southern California UC Irvine OCT Medical Imaging Inc
18. Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display
  
  Explore SPIE | Journal Oct 23 2013 Cardiology
  
  We have developed a novel miniature integrated optical coherence tomography (OCT)-intravascular ultrasound (IVUS) probe, with a 1.5-mm-long rigid part and 0.9-mm outer diameter, for real-time intracoronary imaging of atherosclerotic plaques and guiding of interventional procedures. By placing the OCT ball lens and IVUS transducer back-to-back at the same axial position, this probe can provide automatically coregistered, coaxial OCT-IVUS imaging. To demonstrate its real-time capability, three-dimensional OCT-IVUS imaging of a pig’s coronary artery displaying in polar coordinates, as well as images of three major types of atherosclerotic plaques in human cadaver coronary segments, were obtained using this ...
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  Mentions: University of Southern California UC Irvine
19. Imaging and quantifying Brownian motion of micro- and nanoparticles using phase-resolved Doppler variance optical coherence tomography
  
  Explore SPIE | Journal Apr 1 2013
  
  Different types and sizes of micro- and nanoparticles have been synthesized and developed for numerous applications. It is crucial to characterize the particle sizes. Traditional dynamic light scattering, a predominant method used to characterize particle size, is unable to provide depth resolved information or imaging functions. Doppler variance optical coherence tomography (OCT) measures the spectral bandwidth of the Doppler frequency shift due to the Brownian motion of the particles utilizing the phase-resolved approach and can provide quantitative information about particle size. Spectral bandwidths of Doppler frequency shifts for various sized particles were quantified and were demonstrated to be inversely proportional ...
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  Mentions: UC Irvine
20. Imaging and quantifying Brownian motion of micro- and nanoparticles using phase-resolved Doppler variance optical coherence tomography
  
  Explore SPIE | Journal Mar 22 2013
  
  Different types and sizes of micro- and nanoparticles have been synthesized and developed for numerous applications. It is crucial to characterize the particle sizes. Traditional dynamic light scattering, a predominant method used to characterize particle size, is unable to provide depth resolved information or imaging functions. Doppler variance optical coherence tomography (OCT) measures the spectral bandwidth of the Doppler frequency shift due to the Brownian motion of the particles utilizing the phase-resolved approach and can provide quantitative information about particle size. Spectral bandwidths of Doppler frequency shifts for various sized particles were quantified and were demonstrated to be inversely proportional ...
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  Mentions: UC Irvine
21. High-speed upper-airway imaging using full-range optical coherence tomography
  
  Explore SPIE | Journal Nov 13 2012 Pulmonology
  
  Obstruction in the upper airway can often cause reductions in breathing or gas exchange efficiency and lead to rest disorders such as sleep apnea. Imaging diagnosis of the obstruction region has been accomplished using computed tomography (CT) and magnetic resonance imaging (MRI). However CT requires the use of ionizing radiation, and MRI typically requires sedation of the patient to prevent motion artifacts. Long-range optical coherence tomography (OCT) has the potential to provide high-speed three-dimensional tomographic images with high resolution and without the use of ionizing radiation. In this paper, we present work on the development of a long-range OCT endoscopic ...
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  Mentions: UC Irvine
22. Phase-resolved acoustic radiation force optical coherence elastography
  
  Explore SPIE | Journal Nov 6 2012
  
  Many diseases involve changes in the biomechanical properties of tissue, and there is a close correlation between tissue elasticity and pathology. We report on the development of a phase-resolved acoustic radiation force optical coherence elastography method (ARF-OCE) to evaluate the elastic properties of tissue. This method utilizes chirped acoustic radiation force to produce excitation along the sample’s axial direction, and it uses phase-resolved optical coherence tomography (OCT) to measure the vibration of the sample. Under 500-Hz square wave modulated ARF signal excitation, phase change maps of tissue mimicking phantoms are generated by the ARF-OCE method, and the resulting Young ...
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  Mentions: University of Southern California UC Irvine
23. Endoscopic long range fourier domain optical coherence tomography (LR-FD-OCT)
  
  Explore uspto.gov Oct 9 2012 Gastroenterology , Patents
  
  An endoscopic swept-source Fourier Domain optical coherence tomographic system (FDOCT system) for imaging of tissue structure includes a Fourier Domain mode locked (FDML), high speed, narrow line-width, wavelength swept source, an OCT interferometer having a sample arm, a reference arm, a detection arm, and a source arm coupled to the swept source, an endoscopic probe coupled to the sample arm, and a data processing circuit coupled to the detection arm. The swept source includes a long optic fiber functioning as a cavity, a high optical gain lasing module, and a tunable narrow bandwidth bandpass filter for wavelength selection combined to ...
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  Mentions: UC Irvine
24. Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner
  
  Explore Linking to Scitation Content Jun 28 2012 Cardiology , Probes
  
  We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V–conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit ...
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  Mentions: UC Irvine
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