1. Articles from Mark Ahearne

    1-4 of 4
    1. Investigation of a tissue engineered tendon model by PS-OCT

      Investigation of a tissue engineered tendon model by PS-OCT
      A few native tissues, such as tendon, skin and eye, possess highly organized collagenous matrices. In particular, the collagen fibers in tendon are organized into a hierarchical and unidirectional format, which gives rise to the high tissuespecific mechanical properties. This organization has been clearly revealed by a conventional polarized light microscope. The newly developed polarization-sensitive optical coherence tomography (PS-OCT) technique allows non-invasive visualization of birefringence images arising from orientated structures in a three dimensional format. Our previous studies of native tendon and tissue engineered tendon by PS-OCT demonstrate that tissue engineered tendon has a far less perfect collagen fiber organization ...
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    2. Monitoring the effect of magnetically aligned collagen scaffolds on tendon tissue engineering by Psoct

      As the repair of injured or degenerated tendon is often compromised by the shortage of suitable donor tissue, other procedures need to be developed. The application of a functional tissue engineered tendon could prove to be a promising alternative therapy. Due to their good biocompatibility, collagen hydrogel based scaffolds have been considered to be potentially suitable for engineering tendon tissue in vitro. One of the major limitations of collagen hydrogels for engineering tissues is the difficulty in controlling their architecture and collagen concentration which results in poor mechanical strength. This study aims to overcome these limitations by creating a highly ...
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    3. Online monitoring of collagen fibre alignment in tissue-engineered tendon by PSOCT

      One of the major challenges in engineering a functional tendon is to be able to monitor the evolving arrangement of collagen fibres, which leads to the formation of a complex extracellular matrix. Polarization-sensitive optical coherence tomography (PSOCT) is a non-destructive imaging technique capable of examining the organization of tissues online. In this study, PSOCT was used for the first time to visualize the evolution of the collagen fibre alignment in tissue-engineered tendons in response to varying growth environments. The tendon constructs consisted of rat tenocytes embedded in collagen hydrogels and cultured in Flexcell Tissue Train Culture plates. They were subjected ...
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    4. Application of polarization OCT in tissue engineering

      For tissue engineering of load-bearing tissues, such as bone, tendon, cartilage, and cornea, it is critical to generate a highly organized extracellular matrix. The major component of the matrix in these tissues is collagen, which usually forms a highly hierarchical structure with increasing scale from fibril to fiber bundles. These bundles are ordered into a 3D network to withstand forces such as tensile, compressive or shear. To induce the formation of organized matrix and create a mimic body environment for tissue engineering, in particular, tendon tissue engineering, we have fabricated scaffolds with features to support the formation of uniaxially orientated ...

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    1-4 of 4
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    1. (1 articles) Sun Yat-Sen University
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