1. Articles from Ying Yang

    1-11 of 11
    1. Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method

      Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method

      Damage of collagen fibers in tendons is often directly related to changes in a tendon’s mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment assessment. A feasibility study of quantifying the mechanical properties of a degenerated tendon model by a nondestructive imaging modality, which combines optical coherence elastography and acoustic radiation force (ARF) method, is presented. The degenerated tendon model was produced by the partial degradation of chicken tendons through incubation with collagenase at different concentrations and incubation times. A 30-kHz longitudinal ultrasound transducer was used to provide an ARF ...

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    2. A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response

      A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response

      During aging, collagen structure changes, detrimentally affecting tissues' biophysical and biomechanical properties due to an accumulation of advanced glycation end-products (AGEs). In this investigation, we conducted a parallel study of microscopic and macroscopic properties of different-aged collagens from newborn to 2-yr-old rats, to examine the effect of aging on fibrillogenesis, mechanical and contractile properties of reconstituted hydrogels from these collagens seeded with or without fibroblasts. In addition to fibrillogenesis of collagen under the conventional conditions, some fibrillogenesis was conducted alongside a 12-T magnetic field, and gelation rate and AGE content were measured. A nondestructive indentation technique and optical coherence tomography ...

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      Mentions: Ying Yang
    3. Optical coherence tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface

      Optical coherence tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface

      Polyamidoamine (PAMAM) dendrimers have been topically applied to the skin and utilised as a permeation enhancer for a range of therapeutic compounds. However, very little is known about the mechanism of enhancement. This study used optical coherence tomography (OCT) to investigate the influence of PAMAM dendrimers to alter surface refractive index (RI) in excised porcine skin. It is revealed that PAMAM dendrimers caused a sporadic disruption and disappearance of the white hyper-reflective band on the skin surface using OCT. Following the decontamination of the treated skin specimens, the entrance signal, resulting in the polarised light reflecting off the keratin of ...

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      Mentions: Ying Yang
    4. Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography

      Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography

      The highly orientated collagen fibers in tendons play a critical role for transferring tensile stress, and they demonstrate birefringent optical properties. However, the influence that proteoglycans (PGs) have on the optical properties of tendons is yet to be fully elucidated. PGs are the essential components of the tendon extracellular matrix; the changes in their quantities and compositions have been associated with tendinopathies. In this study, polarization sensitive optical coherence tomography (PS-OCT) has been used to reveal the relationship between PG content/location and birefringence properties of tendons. Fresh chicken tendons were imaged at regular intervals by PS-OCT and polarization light ...

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      Mentions: Ying Yang
    5. The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT

      The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT

      Optimizing and fully understanding the dynamic culture conditions in tissue engineering could accelerate exploration of this new technique into a promising therapy in the medical field. Scaffolds used in tissue engineering usually are highly porous with various pore architecture depending on techniques that manufacture them. Perfusing culture fluid through a scaffold in a bioreactor has proven efficient in enhancing the exchange of nutrients and gas within cell-scaffold constructs. Upon perfusion, flowing fluid in pores inevitably produces shear stress on the wall of the pores, which will in turn induce cellular response for the cells possessing mechanotransducers. Thus, establishing a relationship ...

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    6. Investigation of a tissue engineered tendon model by PS-OCT

      Investigation of a tissue engineered tendon model by PS-OCT
      A few native tissues, such as tendon, skin and eye, possess highly organized collagenous matrices. In particular, the collagen fibers in tendon are organized into a hierarchical and unidirectional format, which gives rise to the high tissuespecific mechanical properties. This organization has been clearly revealed by a conventional polarized light microscope. The newly developed polarization-sensitive optical coherence tomography (PS-OCT) technique allows non-invasive visualization of birefringence images arising from orientated structures in a three dimensional format. Our previous studies of native tendon and tissue engineered tendon by PS-OCT demonstrate that tissue engineered tendon has a far less perfect collagen fiber organization ...
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      Mentions: Ying Yang
    7. Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds

      Yali Jia, Pierre O. Bagnaninchi, Ying Yang et al. Establishing a relationship between perfusion rate and fluid shear stress in a 3D cell culture environment is an ongoing and challenging task faced by tissue engineers. We explore Doppler optical coherence tomography (DOCT) as a potential imaging tool for in situ monitoring of local fluid flow profi ... [J. Biomed. Opt. 14, 034014 (2009)] published Thu May 14, 2009.

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    8. Elastin peptides increase lung cancer cell growth in 3D models

      The lung is an organ heavily involved in cancer as both the origin of lung cancer and where metastases from tumours originating in other organs develop. Therefore, it is obvious that the interaction between cancer cells and lung tissue plays a role in cancer development, invasion, and/or growth. Out of all the components of the lung's extracellular matrix, elastin fragmentation products, the so-called elastin peptides, have been associated with tumour growth and invasion. Therefore, we studied using a 3D model whether elastin peptides could increase the proliferative activity of lung cancer cells. To this purpose, we grew lung ...
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      Mentions: Ying Yang
    9. Monitoring the effect of magnetically aligned collagen scaffolds on tendon tissue engineering by Psoct

      As the repair of injured or degenerated tendon is often compromised by the shortage of suitable donor tissue, other procedures need to be developed. The application of a functional tissue engineered tendon could prove to be a promising alternative therapy. Due to their good biocompatibility, collagen hydrogel based scaffolds have been considered to be potentially suitable for engineering tendon tissue in vitro. One of the major limitations of collagen hydrogels for engineering tissues is the difficulty in controlling their architecture and collagen concentration which results in poor mechanical strength. This study aims to overcome these limitations by creating a highly ...
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      Mentions: Ying Yang
    10. Online monitoring of collagen fibre alignment in tissue-engineered tendon by PSOCT

      One of the major challenges in engineering a functional tendon is to be able to monitor the evolving arrangement of collagen fibres, which leads to the formation of a complex extracellular matrix. Polarization-sensitive optical coherence tomography (PSOCT) is a non-destructive imaging technique capable of examining the organization of tissues online. In this study, PSOCT was used for the first time to visualize the evolution of the collagen fibre alignment in tissue-engineered tendons in response to varying growth environments. The tendon constructs consisted of rat tenocytes embedded in collagen hydrogels and cultured in Flexcell Tissue Train Culture plates. They were subjected ...
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      Mentions: Ying Yang
    11. Application of polarization OCT in tissue engineering

      For tissue engineering of load-bearing tissues, such as bone, tendon, cartilage, and cornea, it is critical to generate a highly organized extracellular matrix. The major component of the matrix in these tissues is collagen, which usually forms a highly hierarchical structure with increasing scale from fibril to fiber bundles. These bundles are ordered into a 3D network to withstand forces such as tensile, compressive or shear. To induce the formation of organized matrix and create a mimic body environment for tissue engineering, in particular, tendon tissue engineering, we have fabricated scaffolds with features to support the formation of uniaxially orientated ...

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      Mentions: Ying Yang
    1-11 of 11
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  2. Topics in the News

    1. (11 articles) Ying Yang
    2. (3 articles) Ruikang K. Wang
    3. (2 articles) Oregon Health & Science University
    4. (2 articles) Yali Jia
    5. (1 articles) University of Washington
    6. (1 articles) Chunhui Li
    7. (1 articles) UC Davis
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    The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT Investigation of a tissue engineered tendon model by PS-OCT Study of optical properties and proteoglycan content of tendons by polarization sensitive optical coherence tomography A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method Optoretinography: optical measurements of human cone and rod photoreceptor responses to light Nodular skin lesions: correlation of reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) features OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT Compensation for the Influence of Fluctuations in the Distance to the Object During Noncontact Probing in Spectral Domain Optical Coherence Tomography Pattern electroretinogram changes in patients with primary open-angle glaucoma in correlation with visual field and optical coherence tomography changes Objective evaluation of proliferative diabetic retinopathy using optical coherence tomography Repeatability of Cornea and Sublayer Thickness Measurements Using Optical Coherence Tomography in Corneas of Anomalous Refractive Status