1. Articles from Carmen A. Puliafito

    25-48 of 52 « 1 2 3 »
    1. Improving image segmentation performance and quantitative analysis via a computer-aided grading methodology for optical coherence tomography retinal image analysis

      Improving image segmentation performance and quantitative analysis via a computer-aided grading methodology for optical coherence tomography retinal image analysis
      We demonstrate quantitative analysis and error correction of optical coherence tomography (OCT) retinal images by using a custom-built, computer-aided grading methodology. A total of 60 Stratus OCT (Carl Zeiss Meditec, Dublin, California) B-scans collected from ten normal healthy eyes are analyzed by two independent graders. The average retinal thickness per macular region is compared with the automated Stratus OCT results. Intergrader and intragrader reproducibility is calculated by Bland-Altman plots of the mean difference between both gradings and by Pearson correlation coefficients. In addition, the correlation between Stratus OCT and our methodology-derived thickness is also presented. The mean thickness difference between ...
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    2. Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography

      Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography
      PURPOSE. To reveal three-dimensional (3D) information about the retinal structures of birds of prey in vivo METHODS. An ultra-high resolution spectral-domain optical coherence tomography (SDOCT) system was built for in vivo imaging of bird of prey retina. The calibrated imaging depth and axial resolution of the system were 3.1 mm and 2.8 µm (in tissue), respectively. 3D segmentation was performed for calculation of the retinal nerve fiber layer (RNFL) map. RESULTS. High resolution OCT images of the retinas of four species of birds of prey: two diurnal hawks (Buteo platypterus and Buteo brachyurus) and two nocturnal owls (Bubo ...
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    3. Surgical Management of Vitreofoveal Traction Syndrome: Optical Coherence Tomographic Evaluation and Clinical Outcomes

      BACKGROUND AND OBJECTIVE To characterize vitreofoveal traction syndrome and to correlate clinical observations, optical coherence tomography features, and surgical results. PATIENTS AND METHODS A retrospective, consecutive, interventional case series of 36 patients. Clinical and optical coherence tomography features taken from patient charts were compared preoperatively and postoperatively and correlated with visual outcomes. RESULTS Preoperatively, visual acuity ranged from 20/40 to 20/400 and improved more than 2 lines in 50% of eyes. A macular hole developed in 2 eyes. The optical coherence tomography appearance of traction resolved in all eyes; cystic change improved markedly or resolved in 86% of ...
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    4. Photoacoustic ophthalmoscopy for in vivo retinal imaging

      Photoacoustic ophthalmoscopy for in vivo retinal imaging

      We have developed a non-invasive photoacousticophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. Byusing a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetricimaging of the retinal micro-vasculature and retinal pigment epithelium at ahigh speed. For B-scan frames containing 256 A-lines, the current PAOMhas a frame rate of 93 Hz, which is comparable with state-of-the-artcommercial spectral-domain optical coherence tomography (SD-OCT). Byintegrating PAOM with SD-OCT, we further achieved OCT-guided PAOM,which can provide multi-modal retinal imaging simultaneously ...

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    5. Ultra-High Resolution Spectral Domain Optical Coherence Tomography of Traumatic Maculopathy

      The authors describe a patient who suffered traumatic maculopathy following blunt trauma to the eye with commotio retinae, subretinal and preretinal hemorrhage, traumatic macular hole, and outer retinal and retinal pigment epithelium disruption. Serial imaging with commercially available and ultra-high resolution spectral domain optical coherence tomography characterized the evolution of the injury. [Ophthalmic Surg Lasers Imaging 2009;40:516-521.]

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    6. Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography

      Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography
      We have developed a multimodal imaging technique by integrating photoacoustic microscopy and spectral domain optical coherence tomography to provide simultaneous volumetric microscopic imaging of both optical absorption and scattering contrasts in biological tissues. In the integrated system, the two imaging modalities share the same optical scanning and delivery mechanisms after their probing and illumination light beams are combined. By further synchronizing the image acquisitions, the images from the two modalities are intrinsically registered. The capabilities of this novel technique were demonstrated by imaging both the microanatomy and microvasculature in mouse ears in vivo.
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    7. Spectral Domain Optical Coherence Tomography Characteristics of Cuticular Drusen

      Purpose: To evaluate the appearance of cuticular drusen with spectral domain optical coherence tomography. Methods: Eyes of patients with cuticular drusen were imaged using a prototype spectral domain optical coherence tomography instrument with 5-μm axial resolution. Thickness maps were obtained after automated segmentation of the internal limiting membrane and retinal pigment epithelium layers using a proprietary algorithm. The volume of subretinal fluid (SRF) was calculated using a manual segmentation technique that involved drawing boundaries around the SRF. The repeatability of these measurements was tested by comparing the volume measurements from multiple scans performed on the same day in four eyes ...
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    8. Spectral Domain Optical Coherence Tomographic Imaging of Geographic Atrophy

      BACKGROUND AND OBJECTIVE To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). PATIENTS AND METHODS Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. RESULTS GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference ...
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    9. Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

      Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

      We have successfully imaged the retinal tumor in a mouse model using an ultra-high resolution spectral-domain optical coherence tomography (SD-OCT) designed for small animal retinal imaging. For segmentation of the tumor boundaries and calculation of the tumor volume, we developed a novel segmentation algorithm. The algorithm is based on parametric deformable models (active contours) and is driven by machine learning-based region classification, namely a Conditional Random Field. With this algorithm we are able to obtain the tumor boundaries automatically, while the user can specify additional constraints (points on the boundary) to correct the segmentation result, if needed. The system and ...

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    10. Spectral Domain Optical Coherence Tomography for Proliferative Diabetic Retinopathy With Subhyaloid Hemorrhage

      A prototype 6-µm axial resolution spectral domain optical coherence tomography (SD-OCT) device was used to image the retina of a patient with uncontrolled diabetes mellitus who had proliferative diabetic retinopathy with subhyaloid hemorrhage. A raster scan pattern with 128 B-scans covering a 6 × 6 × 2-mm volume of the retina was obtained. SD-...
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    11. Macular Spectral-domain Optical Coherence Tomography in Patients with X-linked Retinoschisis

      Purpose: The purpose of this study is to evaluate macular anatomy in patients with X-linked retinoschisis (XLRS) using spectral-domain OCT (SD-OCT).Methods: Consecutive observational case series. Clinical features were obtained through retrospective chart review. Only eyes without prior surgical interventions and those scanned with SD-OCT were included. The OCT images were analyzed. Results: Fourteen eyes of 7 males with XLRS scanned with SD-OCT, age 5 to 45 years, were identified. On clinical examination, stellate spoke-like cystic maculopathy was present in 9 eyes, and an atrophic foveal lesion in 5 eyes. SD-OCT revealed cystoid spaces accounting for retinal splitting in the ...

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    12. Imaging Serpiginous Choroidopathy With Spectral Domain Optical Coherence Tomography

      The use of spectral domain optical coherence tomography (SD-OCT) in the study of chronic serpiginous choroiditis was evaluated. Two patients with chronic serpiginous choroiditis were imaged using two prototype SD-OCT systems (6-µm axial resolution). Raster scans covering 6 × 6 × 2-mm regions of the retina were obtained, enabling the study of different retinal cross-sectional images. Thickness maps were obtained after segmentation of retinal layers, which could be compared with those on follow-up. SD-OCT allowed the visualization of the cross-sectional retinal architecture at different horizontal positions. Superimposition of SD-OCT generated reconstructed fundus images with fundus photographs provided accurate images registration. Segmentation of ...
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    13. Macular Thickness Measurements in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE Knowledge of the macular thickness in a normal population is important for the evaluation of pathological macular change. The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT). PATIENTS AND METHODS Fifty eyes from 50 normal subjects (29 men and 21 women, aged 22 to 68 years) were scanned with a prototype Cirrus HD-OCT system (5 µm axial resolution) (Carl Zeiss Meditec, Inc.). The proprietary Cirrus segmentation algorithm was used to produce retinal thickness maps, which were then averaged over 9 regions defined by a ...
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    14. Calibration of Fundus Images Using Spectral Domain Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE Measurements performed on fundus images using current software are not accurate. Accurate measurements can be obtained only by calibrating a fundus camera using measurements between fixed retinal landmarks, such as the dimensions of the optic nerve, or by relying on a calibrated model eye provided by a reading center. However, calibrated spectral domain OCT (SD-OCT) could offer a convenient alternative method for the calibration of any fundus image. PATIENTS AND METHODS The ability to measure exact distances on SD-OCT fundus images was tested by measuring the distance between the center of the fovea and the optic nerve ...
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    15. Spectral Domain Optical Coherence Tomographic Imaging of Geographic Atrophy

      BACKGROUND AND OBJECTIVE To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using auto fluorescence (FAF). PATIENTS AND METHODS Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. RESULTS GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference ...
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    16. In vivo imaging of raptor retina with ultra high resolution spectral domain optical coherence tomography

      Among birds, raptors are well known for their exceptional eyesight, which is partly due to the unique structure of their retina. Because the raptor retina is the most advanced of any animal species, in vivo examination of its structure would be remarkable. Furthermore, a noticeable percentage of traumatic ocular injuries are identified in birds of prey presented to rehabilitation facilities. Injuries affecting the posterior segment have been considered as a major impact on raptor vision. Hence, in vivo examination of the structure of the posterior segment of the raptors would be helpful for the diagnosis of traumatized birds. The purpose ...

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    17. Enhanced optical coherence tomography for anatomical mapping

      A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye ...
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    18. Automatic retinal blood flow calculation using spectral domain optical coherence tomography

      Keywords (OCIS): (110.4500) Imaging systems : Optical coherence tomography (120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation (170.4580) Medical optics and biotechnology : Optical diagnostics for medicine Abstract Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed
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    19. Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation

      The development of improved segmentation algorithms for more consistently accurate detection of retinal boundaries is a potentially useful solution to the limitations of existing optical coherence tomography (OCT) software. We modeled artifacts related to operator errors that may normally occur during OCT imaging and evaluated their influence on segmentation results using a novel segmentation algorithm. These artifacts included: defocusing, depolarization, decentration, and a combination of defocusing and depolarization. Mean relative reflectance and average thickness of the automatically extracted intraretinal layers was then measured. Our results show that defocusing and depolarization errors together have the greatest altering effect on all measurements ...
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    20. Everyday OCT: A Handbook for Clinicians and Technicians (Book)

      Everyday OCT: A Handbook for Clinicians and Technicians (Book)
      Authorities on OCT technology and imaging, Dr. Joel S. Schuman, Dr. Carmen A. Puliafito, and Dr. James G. Fujimoto review OCT and provide both the beginning and advanced user with expert pearls on how to effectively perform and interpret OCT imaging. Everyday OCT contains a wealth of technical information about the principles of operating the Stratus OCTTM and the main components of this medical diagnostic imaging technology. Everyday OCT explains how to: Set up and employ OCT technology Select and facilitate scans Ensure and assess the quality of scans Accurately interpret OCT images Additional Features: Over 200 color images Tips ...
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    21. Automated detection of retinal layer structures on optical coherence tomography images

      Automated detection of retinal layer structures on optical coherence tomography images
      Segmentation of retinal layers from OCT images is fundamental to diagnose the progress of retinal diseases. In this study we show that the retinal layers can be automatically and/or interactively located with good accuracy with the aid of local coherence information of the retinal structure. OCT images are processed using the ideas of texture analysis by means of the structure tensor combined with complex diffusion filtering. Experimental results indicate that our proposed novel approach has good performance in speckle noise removal, enhancement and segmentation of the various cellular layers of the retina using the STRATUSOCTTM system.
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    22. Optical Coherence Tomography of Ocular Diseases, Second Edition (Book)

      Optical Coherence Tomography of Ocular Diseases, Second Edition (Book)
      Optical Coherence Tomography of Ocular Diseases, Second Edition is a completely revised and updated version of this classic text. Incorporated within over 700 pages are a multitude of updated features unique to this edition including over 1,600 color images, state-of-the-art technology, and case presentations. These elements cohesively work together to successfully demonstrate the retina in normal and diseased states using the innovative Stratus OCTTM. Optical Coherence Tomography of Ocular Diseases, Second Edition is written with the clinician in mind. The text's primary objective is to illustrate the appearance of the eye in health and disease, comparing conventional clinical ...
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    25-48 of 52 « 1 2 3 »
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    1. (52 articles) Carmen A. Puliafito
    2. (42 articles) University of Southern California
    3. (27 articles) University of Miami
    4. (16 articles) Carl Zeiss Meditec
    5. (14 articles) Shuliang Jiao
    6. (14 articles) Giovanni Gregori
    7. (12 articles) Robert W. Knighton
    8. (8 articles) Massachusetts Institute of Technology
    9. (8 articles) Joel S. Schuman
    10. (8 articles) Philip J. Rosenfeld
    11. (1 articles) Institute of Applied Physics
    12. (1 articles) Xincheng Yao
    13. (1 articles) Grigory V. Gelikonov
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    15. (1 articles) Pavel A. Shilyagin
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    Method and apparatus for performing optical measurements Everyday OCT: A Handbook for Clinicians and Technicians (Book) Optical Coherence Tomography of Ocular Diseases, Second Edition (Book) Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography Photoacoustic ophthalmoscopy for in vivo retinal imaging Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging Postdoctoral opening in optical instrumentation and retinal imaging at University of Illinois at Chicago Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol Optical coherence tomography versus intravascular ultrasound for culprit lesion assessment in patients with acute myocardial infarction Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study Short-term healing response after implantation of the thin-strut, fast-releasing sirolimus-eluting biodegradable polymer-coated Alex Plus stent: optical coherence tomography study