1. Articles from Carmen A. Puliafito

    1-24 of 52 1 2 3 »
    1. Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography

      Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography

      Purpose To quantitatively evaluate the retinal microvasculature in human subjects with retinal venous occlusions (RVO) using optical coherence tomography angiography (OCTA). Design Retrospective, cross-sectional, observational case series. Participants Sixty subjects (84 eyes) were included (20 BRVO, 14 CRVO, 24 unaffected fellow eyes, and 26 controls). Methods OCTA was performed on a prototype, spectral domain-OCTA system in the 3x3mm central macular region. Custom software was used to quantify morphology and density of retinal capillaries using four quantitative parameters. The vasculature of the segmented retinal layers and nonsegmented whole retina were analyzed. Main outcome measures Fractal dimension (FD), vessel density (VD), skeletal ...

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    2. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography

      Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography

      Purpose To quantify retinal capillary density and morphology in uveitis using SD-OCTA. Design Cross-sectional, observational study Methods Healthy and uveitic subjects were recruited from two tertiary care eye centers. Prototype SD-OCTA devices (Cirrus, Carl Zeiss Meditec, Inc., Dublin, CA) were used to generate 3x3 mm 2 OCTA images centered on the fovea. Subjects were placed into 3 groups based on the type of optical microangiography (OMAG) algorithm used for image processing (intensity- and/or phase) and type of retinal segmentation (automatic or manual). A semi-automated method was used to calculate skeleton density (SD), vessel density (VD), fractal dimension (FD), and ...

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    3. Widefield OCT Findings of a Patient With Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis

      Widefield OCT Findings of a Patient With Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis

      The authors report extensive peripheral retinoschisis in a patient with stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) detected by widefield optical coherence tomography (OCT). A 64-year-old woman diagnosed with foveomacular retinoschisis 3 years prior presented for evaluation after being seen by multiple other retina specialists. Standard macular spectral-domain OCT (6 mm) revealed typical foveomacular schisis involving only the outer retina. However, widefield OCT (12 mm) revealed diffuse bilateral retinoschisis involving both inner and outer retinal layers in the macula and midperiphery. Widefield imaging is important to evaluate and monitor complex peripheral retinoschisis that may be otherwise undetectable using conventional techniques.

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    4. Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography

      Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography

      Purpose : To quantify changes in retinal microvasculature in diabetic retinopathy (DR) by using spectral-domain optical coherence tomography angiography (SD-OCTA). Methods : Retrospective, cross-sectional, observational study of healthy and diabetic adult subjects with and without DR. Retinal microvascular changes were assessed by using SD-OCTA images and an intensity-based optical microangiography algorithm. A semiautomated program was used to calculate indices of microvascular density and morphology in nonsegmented and segmented SD-OCTA images. Microvascular density was quantified by using skeleton density (SD) and vessel density (VD), while vessel morphology was quantified as fractal dimension (FD) and vessel diameter index (VDI). Statistical analyses were performed by ...

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    5. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION

      Purpose: To noninvasively evaluate the retinal microvasculature in human subjects with retinal venous occlusions using optical coherence tomography angiography and assess potential clinical applications. Methods: This was a prospective, observational study of adult human subjects with clinical and imaging findings demonstrating retinal venous occlusion. Subjects underwent complete ophthalmic examination and fluorescein angiography as appropriate for their standard of care. Optical coherence tomography angiography was performed on a prototype spectral domain-OCTA system in 3 mm x 3 mm and 6 mm x 6 mm regions centered on the fovea and parafoveal areas. Retinal vasculature was assessed within three horizontal slabs consisting ...

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    6. Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects

      Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects

      BACKGROUND AND OBJECTIVE: Optical coherence tomography angiography (OCTA) is a novel, non-invasive OCT technique capable of imaging the retinal vasculature. This study aims to evaluate the retinal microvasculature in diabetic human subjects with OCTA and assess potential clinical applications. PATIENTS AND METHODS: Cross-sectional study of 33 subjects with diabetic retinopathy. OCTA was performed on 3 mm × 3 mm sections using a swept-source OCTA prototype and a phase- and intensity-based contrasting algorithm. OCT angiograms were studied with corresponding clinical examination and fluorescein angiograms, when available, to assess accuracy and clinical utility. RESULTS: OCTA was able to demonstrate most clinically relevant vascular ...

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    7. Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging

      Feature Of The Week 4/20/2015: Optical Coherence Photoacoustic Microscopy for In Vivo Multimodal Retinal Imaging

      We developed an optical coherence photoacoustic microscopy (OC-PAM) system, which can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously by using a single pulsed broadband light source. With a center wavelength of 800 nm and a bandwidth of 30 nm, the system is suitable for imaging the retina. Generated from the same group of photons, the OCT and PAM images are intrinsically registered in the lateral directions. To test the capabilities of the system on multimodal ophthalmic imaging, we imaged the retina of pigmented rats. The OCT images showed the retinal structures with quality similar to conventional OCT ...

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    8. Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

      Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

      We developed an optical coherence photoacoustic microscopy (OC-PAM) system, which can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously by using a single pulsed broadband light source. With a center wavelength of 800 nm and a bandwidth of 30 nm, the system is suitable for imaging the retina. Generated from the same group of photons, the OCT and PAM images are intrinsically registered in the lateral directions. To test the capabilities of the system on multimodal ophthalmic imaging, we imaged the retina of pigmented rats. The OCT images showed the retinal structures with quality similar to conventional OCT ...

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    9. OCT Angiography in Healthy Human Subjects

      OCT Angiography in Healthy Human Subjects

      BACKGROUND AND OBJECTIVE: To noninvasively evaluate the retinal microvasculature in healthy human subjects with optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Cross-sectional, observational study of five healthy subjects. OCTA was performed on 3 × 3 mm(2) sections centered on the fovea, nasal macula, and temporal macula. Retinal vasculature was assessed within three horizontal slabs consisting of the inner, middle, and outer retina. The vasculature within each retinal slab was reconstructed using phase-based and intensity contrast-based algorithms and visualized as separate en face images. RESULTS: OCTA in healthy subjects demonstrates capillary networks consistent with previous histological studies. No retinal vessels ...

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    10. Macular Thickness Measurements in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      Macular Thickness Measurements in Normal Eyes Using Spectral Domain Optical Coherence Tomography

      BACKGROUND AND OBJECTIVE: Knowledge of the macular thickness in a normal population is important for the evaluation of pathological macular change. The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT). PATIENTS AND METHODS: Fifty eyes from 50 normal subjects (29 men and 21 women, aged 22 to 68 years) were scanned with a prototype Cirrus HD-OCT system (5 µm axial resolution) (Carl Zeiss Meditec, Inc.). The proprietary Cirrus segmentation algorithm was used to produce retinal thickness maps, which were then averaged over 9 regions defined by a ...

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    11. OCT in the Management of Macular Degeneration - Ophthalmology Education Lab

      OCT in the Management of Macular Degeneration - Ophthalmology Education Lab

      Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...

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    12. Optical coherence tomography 2014

      Optical coherence tomography 2014

      Optical coherence tomography (OCT) is now widely recognized as the most important retinal imaging technique, replacing angiographic techniques as first-line imaging tools. This has largely been driven by widespread application of retinal pharmacotherapy. As a clinical decision-making tool in that setting, OCT has unparalleled value in delivering important information in a matter of seconds. OCT has dramatically improved the productivity of retinal specialists — ie, the number of patients who can be evaluated in a given clinical session. This special issue on OCT highlights its value as a quantitative tool in assessing retinal anatomy in both health and disease, its power ...

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    13. Absolute retinal blood flow measurement with a dual-beam Doppler optical coherence tomography

      Absolute retinal blood flow measurement with a dual-beam Doppler optical coherence tomography

      Purpose:To test the capability of a novel dual-beam Doppler optical coherence tomography (OCT) technique for simultaneous in vivo measurement of the Doppler angle and, thus, the absolute retinal blood velocity and the retinal flow rate, without the influence of motion artifacts. Methods:A novel dual-beam Doppler spectral domain OCT (SD-OCT) was developed. The two probing beams are separated with a controllable distance along an arbitrary direction, both of which are controlled by two independent 2D optical scanners. Two sets of optical Doppler tomography (ODT) images are acquired simultaneously. The Doppler angle of each blood vessel segment was calculated from ...

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    14. Enhanced optical coherence tomography for anatomical mapping

      Enhanced optical coherence tomography for anatomical mapping

      A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye ...

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    15. Further advances in optical coherence tomography 2012

      Further advances in optical coherence tomography 2012

      This fourth annual supplement to Ophthalmic Surgery, Lasers & Imaging devoted to optical coherence tomography (OCT) is a testament to the unique status and evolution of perhaps the single most important development of the era in ophthalmic imaging. Presented here are the latest reports of diagnosis and treatment challenges utilizing OCT to study and solve the problem and benefit the patient. They describe the most recent technological innovations and applications of the technique first described in 1991 in the journal Science , 1 and as a group represent the broad range of relevance of this imaging technique. Original clinical and experimental studies ...

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    16. Optical Coherence Tomography of Ocular Diseases, Third Edition (Book)

      Optical Coherence Tomography of Ocular Diseases, Third Edition (Book)

      For more than 17 years, Optical Coherence Tomography of Ocular Diseases has been the classic text on this essential imaging technology. This completely revised and updated Third Edition of Optical Coherence Tomography of Ocular Diseases reflects the quickly advancing technology of spectral domain optical coherence tomography (SD-OCT). Incorporated within over 600 pages are a multitude of updated features unique to this Third Edition including over 1,200 color images, state-of-the-art technology, and case presentations. These elements cohesively work together to successfully demonstrate the retina in normal and diseased states using SD-OCT. Optical Coherence Tomography of Ocular Diseases, Third Edition is ...

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    17. Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      Visible light optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      The ultimate goal of the study is to provide an imaging tool to detect the earliest signs of glaucoma before clinically visible damage occurs to the retinal nerve fiber layer (RNFL). Studies have shown that the optical reflectance of the damaged RNFL at short wavelength ( reduced much more than that at long wavelength, which provides spectral contrasts for imaging the earliest damage to the RNFL. To image the spectral contrasts we built a dual-band spectral-domain optical coherence tomography (SD-OCT) with centered wavelength of 415nm (VIS) and 808nm (NIR), respectively. The light at the two bands was provided by the fundamental ...

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    18. Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      Dual-band spectral-domain optical coherence tomography for in vivo imaging the spectral contrasts of the retinal nerve fiber layer

      The ultimate goal of the study is to provide an imaging tool to detect the earliest signs of glaucoma before clinically visible damage occurs to the retinal nerve fiber layer (RNFL). Studies have shown that the optical reflectance of the damaged RNFL at short wavelength (<560nm) is reduced much more than that at long wavelength, which provides spectral contrast for imaging the earliest damage to the RNFL. To image the spectral contrast we built a dual-band spectral-domain optical coherence tomography (SD-OCT) centered at 808nm (NIR) and 415nm (VIS). The light at the two bands was provided by the fundamental and frequency-doubled outputs of a broadband Ti:Sapphire laser. The depth resolution of the NIR and VIS OCT systems are 4.7µm and 12.2µm in the air, respectively. The system was applied to imaging the rat retina in vivo. Significantly different appearances between the OCT cross sectional images at the two bands were observed. The ratio of the light reflected from the RNFL over that reflected from the entire retina at the two bands were quantitatively compared. The experimental results showed that the dual-band OCT system is feasible for imaging the spectral contrasts of the RNFL.

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    19. Photoacoustic Ophthalmoscopy for In Vivo Retinal Imaging: Current Status and Prospects

      Photoacoustic Ophthalmoscopy for In Vivo Retinal Imaging: Current Status and Prospects

      Photoacoustic ophthalmoscopy (PAOM) is a new retinal imaging technology that offers the unique capability to measure optical absorption in the retina. Because PAOM is compatible with optical coherence tomography, scanning laser ophthalmoscopy, and autofluorescence imaging, registered multimodal images can be acquired from a single device at comparable resolution for comprehensive anatomic and functional retinal characterizations. Therefore, PAOM is anticipated to have applications in both research and clinical diagnosis of many blinding diseases. The authors explain the basic principles of the photoacoustic effect and imaging. Then, different types of photoacoustic microscopy are introduced and compared. Finally, the current status of photoacoustic ...

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    20. Spectral Domain Optical Coherence Tomography Imaging of Drusen in Nonexudative Age-Related Macular Degeneration

      Spectral Domain Optical Coherence Tomography Imaging of Drusen in Nonexudative Age-Related Macular Degeneration
      Purpose: To measure drusen area and volume in eyes with nonexudative age-related macular degeneration (AMD) using spectral domain optical coherence tomography imaging (SD-OCT). Design: Evaluation of diagnostic technology. Participants: One hundred three eyes from 74 patients with drusen. Methods: Patients with drusen secondary to nonexudative AMD were enrolled in this study. Five separate SD-OCT scans, each consisting of 40 000 uniformly spaced A-scans organized as 200 A-scans in each B-scan and 200 horizontal B-scans, were performed on each eye. Each scan covered a retinal area of 6 × 6 mm centered on the fovea. A novel algorithm was used to quantitatively ...
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    21. Optical Coherence Tomography: 20 Years After

      Optical Coherence Tomography: 20 Years After
      Almost 20 years ago, in November 1991, the first description of optical coherence tomography (OCT) was published in the journal Science.1 The first clinical instrument was developed and studied at the New England Eye Center and Tufts University School of Medicine in Boston.2-7 It is conservatively estimated that more than 20,000 OCT systems are in use around the world. OCT initially revolutionized the diagnosis and treatment of macular disease, accelerated by the widespread use of intravitreally delivered drugs for the treatment of neovascular macular degeneration and diabetic macular edema. OCT-based quantitative assessment of the retinal nerve fiber ...
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    22. Retinal Layer Thickness Changes in Eyes With Preserved VisualAcuity and Diffuse Diabetic Macular Edema on Optical CoherenceTomography

      Retinal Layer Thickness Changes in Eyes With Preserved VisualAcuity and Diffuse Diabetic Macular Edema on Optical CoherenceTomography
      BACKGROUND AND OBJECTIVE Diabetic macular edema has several patterns on optical coherence tomography. This retrospective study aimed to assess which retinal layers show thickness changes in type 1 diffuse diabetic macular edema with preserved vision. PATIENTS AND METHODS Eleven eyes with diffuse diabetic macular edema on optical coherence tomography and eight control eyes with 20/20 best-corrected visual acuity were enrolled. Optical coherence tomography images were segmented using an algorithm of the authors’ design (OCTRIMA): regional thickness data in the central area, pericentral rings, and peripheral rings were obtained for the retinal cellular layers. RESULTS The retinal nerve fiber layer ...
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    1-24 of 52 1 2 3 »
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    1. (52 articles) Carmen A. Puliafito
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