Articles from Carmen A. Puliafito

1-25 of 28 // 1 2 »
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  1. Improving image segmentation performance and quantitative analysis via a computer-aided grading methodology for optical coherence tomography retinal image analysis

    Explore Article SPIE Digital Library (Aug 9 2010) Ophthalmology

    Improving image segmentation performance and quantitative analysis via a computer-aided grading methodology for optical coherence tomography retinal image analysis We demonstrate quantitative analysis and error correction of optical coherence tomography (OCT) retinal images by using a custom-built, computer-aided grading methodology. A total of 60 Stratus OCT (Carl Zeiss Meditec, Dublin, California) B-scans collected from ten normal healthy eyes are analyzed by two independent graders. The average retinal thickness per macular region is compared with the automated Stratus OCT results. Intergrader and intragrader reproducibility is calculated by Bland-Altman plots of the mean difference between both gradings and by Pearson correlation coefficients. In addition, the correlation between Stratus OCT and our methodology-derived thickness is also presented. The mean thickness difference between ... (Read Full Article)

    Comment on Article Mentions:   Zeiss Stratus OCT   Harry M. Salinas   Mount Sinai School of Medicine

  2. Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography

    Explore Article iovs.org (Jun 20 2010) Ophthalmology

    Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography PURPOSE. To reveal three-dimensional (3D) information about the retinal structures of birds of prey in vivo METHODS. An ultra-high resolution spectral-domain optical coherence tomography (SDOCT) system was built for in vivo imaging of bird of prey retina. The calibrated imaging depth and axial resolution of the system were 3.1 mm and 2.8 µm (in tissue), respectively. 3D segmentation was performed for calculation of the retinal nerve fiber layer (RNFL) map. RESULTS. High resolution OCT images of the retinas of four species of birds of prey: two diurnal hawks (Buteo platypterus and Buteo brachyurus) and two nocturnal owls (Bubo virginianus and ... (Read Full Article)

    Comment on Article Mentions:   Marco B. Ruggeri   Shuliang Jiao   Carmen A. Puliafito

  3. Surgical Management of Vitreofoveal Traction Syndrome: Optical Coherence Tomographic Evaluation and Clinical Outcomes

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Mar 29 2010) Ophthalmology

    BACKGROUND AND OBJECTIVE To characterize vitreofoveal traction syndrome and to correlate clinical observations, optical coherence tomography features, and surgical results. PATIENTS AND METHODS A retrospective, consecutive, interventional case series of 36 patients. Clinical and optical coherence tomography features taken from patient charts were compared preoperatively and postoperatively and correlated with visual outcomes. RESULTS Preoperatively, visual acuity ranged from 20/40 to 20/400 and improved more than 2 lines in 50% of eyes. A macular hole developed in 2 eyes. The optical coherence tomography appearance of traction resolved in all eyes; cystic change improved markedly or resolved in 86% of eyes. Preoperative ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Southern California   University of Miami

  4. Photoacoustic ophthalmoscopy for in vivo retinal imaging

    Explore Article opticsinfobase.org (Feb 12 2010) Ophthalmology

    Photoacoustic ophthalmoscopy for in vivo retinal imaging We have developed a non-invasive photoacoustic ophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high speed. For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT). By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, ... (Read Full Article)

    Comment on Article Mentions:   Shuliang Jiao   Carmen A. Puliafito   University of Wisconsin

  5. Optical Coherence Tomography: A New Tool for Intraoperative Decision Making

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Feb 5 2010) Ophthalmology

    Optical coherence tomography (OCT) has traditionally been used in the outpatient environment as an important diagnostic tool for retinal clinical decision making. Recent advances in OCT technology have made intraoperative use of OCT feasible. (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Southern California

  6. Ultra-High Resolution Spectral Domain Optical Coherence Tomography of Traumatic Maculopathy

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Sep 24 2009) Ophthalmology

    The authors describe a patient who suffered traumatic maculopathy following blunt trauma to the eye with commotio retinae, subretinal and preretinal hemorrhage, traumatic macular hole, and outer retinal and retinal pigment epithelium disruption. Serial imaging with commercially available and ultra-high resolution spectral domain optical coherence tomography characterized the evolution of the injury. [Ophthalmic Surg Lasers Imaging 2009;40:516-521.] (Read Full Article)

    Comment on Article Mentions:   Giovanni Gregori   Shuliang Jiao   Carmen A. Puliafito

  7. Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography

    Explore Article opticsinfobase.org (Sep 22 2009) Microscopy

    Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography We have developed a multimodal imaging technique by integrating photoacoustic microscopy and spectral domain optical coherence tomography to provide simultaneous volumetric microscopic imaging of both optical absorption and scattering contrasts in biological tissues. In the integrated system, the two imaging modalities share the same optical scanning and delivery mechanisms after their probing and illumination light beams are combined. By further synchronizing the image acquisitions, the images from the two modalities are intrinsically registered. The capabilities of this novel technique were demonstrated by imaging both the microanatomy and microvasculature in mouse ears in vivo. (Read Full Article)

    Comment on Article Mentions:   Shuliang Jiao   Carmen A. Puliafito   Hao F. Zhang

  8. Spectral Domain Optical Coherence Tomography Characteristics of Cuticular Drusen

    Explore Article LWW Online (Jul 11 2009) Ophthalmology

    Purpose: To evaluate the appearance of cuticular drusen with spectral domain optical coherence tomography. Methods: Eyes of patients with cuticular drusen were imaged using a prototype spectral domain optical coherence tomography instrument with 5-μm axial resolution. Thickness maps were obtained after automated segmentation of the internal limiting membrane and retinal pigment epithelium layers using a proprietary algorithm. The volume of subretinal fluid (SRF) was calculated using a manual segmentation technique that involved drawing boundaries around the SRF. The repeatability of these measurements was tested by comparing the volume measurements from multiple scans performed on the same day in four eyes ... (Read Full Article)

    Comment on Article Mentions:   Giovanni Gregori   Carmen A. Puliafito   Philip J. Rosenfeld

  9. Spectral Domain Optical Coherence Tomographic Imaging of Geographic Atrophy

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Apr 6 2009) Ophthalmology

    BACKGROUND AND OBJECTIVE To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). PATIENTS AND METHODS Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. RESULTS GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference ... (Read Full Article)

    Comment on Article Mentions:   Carl Zeiss Meditec   Philip J. Rosenfeld   University of Miami

  10. Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

    Explore Article opticsinfobase.org (Mar 2 2009) Oncology , Ophthalmology

    Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography We have successfully imaged the retinal tumor in a mouse model using an ultra-high resolution spectral-domain optical coherence tomography (SD-OCT) designed for small animal retinal imaging. For segmentation of the tumor boundaries and calculation of the tumor volume, we developed a novel ... [Opt. Express 17, 4074-4083 (2009)] (Read Full Article)

    Comment on Article Mentions:   Shuliang Jiao   Marco B. Ruggeri   Carmen A. Puliafito

  11. Spectral Domain Optical Coherence Tomography for Proliferative Diabetic Retinopathy With Subhyaloid Hemorrhage

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Dec 11 2008) Ophthalmology

    A prototype 6-µm axial resolution spectral domain optical coherence tomography (SD-OCT) device was used to image the retina of a patient with uncontrolled diabetes mellitus who had proliferative diabetic retinopathy with subhyaloid hemorrhage. A raster scan pattern with 128 B-scans covering a 6 × 6 × 2-mm volume of the retina was obtained. SD-... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Southern California   University of Miami

  12. Macular Spectral-domain Optical Coherence Tomography in Patients with X-linked Retinoschisis

    Explore Article BJO Online (Nov 18 2008) Ophthalmology

    Purpose: The purpose of this study is to evaluate macular anatomy in patients with X-linked retinoschisis (XLRS) using spectral-domain OCT (SD-OCT). Methods: Consecutive observational case series. Clinical features were obtained through retrospective chart review. Only eyes without prior surgical interventions and those scanned with SD-OCT were included. The OCT images were analyzed. Results: Fourteen eyes of 7 males with XLRS scanned with SD-OCT, age 5 to 45 years, were identified. On clinical examination, stellate spoke-like cystic maculopathy was present in 9 eyes, and an atrophic foveal lesion in 5 eyes. SD-OCT revealed cystoid spaces accounting for retinal splitting in the ... (Read Full Article)

    Comment on Article Mentions:   University of Southern California   Carmen A. Puliafito   University of Miami

  13. Imaging Serpiginous Choroidopathy With Spectral Domain Optical Coherence Tomography

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Sep 10 2008) Ophthalmology

    The use of spectral domain optical coherence tomography (SD-OCT) in the study of chronic serpiginous choroiditis was evaluated. Two patients with chronic serpiginous choroiditis were imaged using two prototype SD-OCT systems (6-µm axial resolution). Raster scans covering 6 × 6 × 2-mm regions of the retina were obtained, enabling the study of different retinal cross-sectional images. Thickness maps were obtained after segmentation of retinal layers, which could be compared with those on follow-up. SD-OCT allowed the visualization of the cross-sectional retinal architecture at different horizontal positions. Superimposition of SD-OCT generated reconstructed fundus images with fundus photographs provided accurate images registration. ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Southern California   Carl Zeiss Meditec

  14. Macular Thickness Measurements in Normal Eyes Using Spectral Domain Optical Coherence Tomography

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Sep 10 2008) Ophthalmology

    BACKGROUND AND OBJECTIVE Knowledge of the macular thickness in a normal population is important for the evaluation of pathological macular change. The purpose of this study was to define and measure macular thickness in normal eyes using spectral domain optical coherence tomography (OCT). PATIENTS AND METHODS Fifty eyes from 50 normal subjects (29 men and 21 women, aged 22 to 68 years) were scanned with a prototype Cirrus HD-OCT system (5 µm axial resolution) (Carl Zeiss Meditec, Inc.). The proprietary Cirrus segmentation algorithm was used to produce retinal thickness maps, which were then averaged over 9 regions defined by a ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Southern California   University of Miami

  15. Calibration of Fundus Images Using Spectral Domain Optical Coherence Tomography

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Sep 10 2008) Ophthalmology

    BACKGROUND AND OBJECTIVE Measurements performed on fundus images using current software are not accurate. Accurate measurements can be obtained only by calibrating a fundus camera using measurements between fixed retinal landmarks, such as the dimensions of the optic nerve, or by relying on a calibrated model eye provided by a reading center. However, calibrated spectral domain OCT (SD-OCT) could offer a convenient alternative method for the calibration of any fundus image. PATIENTS AND METHODS The ability to measure exact distances on SD-OCT fundus images was tested by measuring the distance between the center of the fovea and the optic nerve. ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Southern California   University of Miami

  16. Spectral Domain Optical Coherence Tomographic Imaging of Geographic Atrophy

    Explore Article Ophthalmic Surgery, Lasers and Imaging (Sep 10 2008) Ophthalmology

    BACKGROUND AND OBJECTIVE To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using auto fluorescence (FAF). PATIENTS AND METHODS Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. RESULTS GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Southern California   University of Miami

  17. Surgeon suggests using OCT for preop cataract evaluation to protect patient, physician

    Explore Article OSN Supersite (Jul 29 2008) Ophthalmology

    Surgeon suggests using OCT for preop cataract evaluation to protect patient, physician BUENOS AIRES; Using optical coherence tomography before cataract surgery can alert a surgeon to any underlying macular disease, allowing the surgeon to better prepare the patient, a surgeon said here. (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Southern California

  18. In vivo imaging of raptor retina with ultra high resolution spectral domain optical coherence tomography

    Explore Article SPIE Digital Library (Feb 11 2008) Ophthalmology

    Among birds, raptors are well known for their exceptional eyesight, which is partly due to the unique structure of their retina. Because the raptor retina is the most advanced of any animal species, in vivo examination of its structure would be remarkable. Furthermore, a noticeable percentage of traumatic ocular injuries are identified in birds of prey presented to rehabilitation facilities. Injuries affecting the posterior segment have been considered as a major impact on raptor vision. Hence, in vivo examination of the structure of the posterior segment of the raptors would be helpful for the diagnosis of traumatized birds. The purpose ... (Read Full Article)

    Comment on Article Mentions:   Marco B. Ruggeri   Shuliang Jiao   Carmen A. Puliafito

  19. Enhanced optical coherence tomography for anatomical mapping

    Explore Article uspto.gov (Nov 27 2007) Ophthalmology , Patents

    A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   Giovanni Gregori   University of Miami

  20. Automatic retinal blood flow calculation using spectral domain optical coherence tomography

    Explore Article opticsinfobase.org (Nov 7 2007) Ophthalmology , Doppler

    Keywords (OCIS): (110.4500) Imaging systems : Optical coherence tomography (120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation (170.4580) Medical optics and biotechnology : Optical diagnostics for medicine Abstract Optical Doppler tomography (ODT) is a branch of optical coherence tomography (OCT) that can measure the speed of a blood flow by measuring the Doppler shift impinged on the probing sample light by the moving blood cells. However, the measured speed (Read Full Article)

    Comment on Article Mentions:   Marco B. Ruggeri   Giovanni Gregori   Hassan M. Wehbe

  21. Evaluation of potential image acquisition pitfalls during optical coherence tomography and their influence on retinal image segmentation

    Explore Article SPIE Digital Library (Aug 30 2007) Ophthalmology

    The development of improved segmentation algorithms for more consistently accurate detection of retinal boundaries is a potentially useful solution to the limitations of existing optical coherence tomography (OCT) software. We modeled artifacts related to operator errors that may normally occur during OCT imaging and evaluated their influence on segmentation results using a novel segmentation algorithm. These artifacts included: defocusing, depolarization, decentration, and a combination of defocusing and depolarization. Mean relative reflectance and average thickness of the automatically extracted intraretinal layers was then measured. Our results show that defocusing and depolarization errors together have the greatest altering effect on all measurements ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Miami   Delia Cabrera Fernández

  22. Everyday OCT: A Handbook for Clinicians and Technicians (Book)

    Explore Article Slack Books (Sep 25 2006) Ophthalmology , Textbooks

    Everyday OCT: A Handbook for Clinicians and Technicians (Book) Authorities on OCT technology and imaging, Dr. Joel S. Schuman, Dr. Carmen A. Puliafito, and Dr. James G. Fujimoto review OCT and provide both the beginning and advanced user with expert pearls on how to effectively perform and interpret OCT imaging. Everyday OCT contains a wealth of technical information about the principles of operating the Stratus OCTTM and the main components of this medical diagnostic imaging technology. Everyday OCT explains how to: Set up and employ OCT technology Select and facilitate scans Ensure and assess the quality of scans Accurately interpret OCT images Additional Features: Over 200 color images Tips ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   Massachusetts Institute of Technology   James G. Fujimoto

  23. Automated detection of retinal layer structures on optical coherence tomography images

    Explore Article opticsinfobase.org (Dec 12 2005) Ophthalmology

    Automated detection of retinal layer structures on optical coherence tomography images Segmentation of retinal layers from OCT images is fundamental to diagnose the progress of retinal diseases. In this study we show that the retinal layers can be automatically and/or interactively located with good accuracy with the aid of local coherence information of the retinal structure. OCT images are processed using the ideas of texture analysis by means of the structure tensor combined with complex diffusion filtering. Experimental results indicate that our proposed novel approach has good performance in speckle noise removal, enhancement and segmentation of the various cellular layers of the retina using the STRATUSOCTTM system. (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   University of Miami   Delia Cabrera Fernández

  24. Optical Coherence Tomography of Ocular Diseases, Second Edition (Book)

    Explore Article Slack Books (Apr 19 2004) Ophthalmology , Textbooks

    Optical Coherence Tomography of Ocular Diseases, Second Edition (Book) Optical Coherence Tomography of Ocular Diseases, Second Edition is a completely revised and updated version of this classic text. Incorporated within over 700 pages are a multitude of updated features unique to this edition including over 1,600 color images, state-of-the-art technology, and case presentations. These elements cohesively work together to successfully demonstrate the retina in normal and diseased states using the innovative Stratus OCTTM. Optical Coherence Tomography of Ocular Diseases, Second Edition is written with the clinician in mind. The text's primary objective is to illustrate the appearance of the eye in health and disease, comparing conventional clinical technologies using ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   Massachusetts Institute of Technology   James G. Fujimoto

  25. Method and apparatus for performing optical measurements

    Explore Article uspto.gov (Oct 17 1995) Patents

    Method and apparatus for performing optical measurements A method and apparatus for performing various optical measurements is provided utilizing an optical coherence domain refrectometer (OCDR). A short coherence optical radiation source applies optical radiation through like optical paths to a sample and an optical reflector. The optical reflector is movable in accordance with a predetermined velocity profile to permit interferometric scanning of the sample, the resulting output having a Doppler shift frequency modulation. This output may be demodulated and detected to obtain desired measurements and other information. Additional information may be obtained by applying radiation from two or more sources at different wavelengths to the sample and ... (Read Full Article)

    Comment on Article Mentions:   Carmen A. Puliafito   Massachusetts Institute of Technology   James G. Fujimoto

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